4-Aminopyridine

Pricing Availability Delivery Time Qty
Cat.No. 0940 - 4-Aminopyridine | C5H6N2 | CAS No. 504-24-5
Description: Non-selective KV channel blocker
Alternative Names: 4-AP
Purity: ≥99% (HPLC)
Datasheet
Citations (21)
Reviews
Literature

Biological Activity

Non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Caged 4-AP (Cat. No. 3557) is also available.

Technical Data

M. Wt 94.12
Formula C5H6N2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 504-24-5
PubChem ID 1727
InChI Key NUKYPUAOHBNCPY-UHFFFAOYSA-N
Smiles NC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.41 100
water 9.41 100

Preparing Stock Solutions

The following data is based on the product molecular weight 94.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 10.62 mL 53.12 mL 106.25 mL
5 mM 2.12 mL 10.62 mL 21.25 mL
10 mM 1.06 mL 5.31 mL 10.62 mL
50 mM 0.21 mL 1.06 mL 2.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bouchard and Fedida (1995) Closed and open state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J.Pharmacol.Exp.Ther. 275 864 PMID: 7473178

Smith et al (2009) In vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative. Clin.Exp.Pharmacol.Physiol. 36 1104 PMID: 19413590

Tseng et al (1996) Reverse use dependence of Kv4.2 blockade by 4-aminopyridine. J.Pharmacol.Exp.Ther. 279 865 PMID: 8930194

Tseng (1999) Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments. J.Pharmacol.Exp.Ther. 290 569 PMID: 10411564


If you know of a relevant reference for 4-Aminopyridine, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Blockers

Keywords: 4-Aminopyridine, supplier, K+, channel, blocker, Potassium, Channels, voltage-gated, voltage-dependent, Kv, hERG, Human, Ether-A-Go-Go, Gene, KCNQ, 4-AP, Voltage-Gated, Potassium, Channels, Voltage-Gated, Potassium, Channels, Tocris Bioscience

21 Citations for 4-Aminopyridine

Citations are publications that use Tocris products. Selected citations for 4-Aminopyridine include:

Dinamarca et al (2016) Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus. Elife 5 PMID: 26977767

Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Front Neural Circuits 4 PMID: 25723967

Curcio et al (2015) Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. J Neurosci 6 e1645 PMID: 25675305

Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. Front Cell Neurosci 35 5664 PMID: 25855180

Robinson et al (2015) Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons. J Neurosci 9 404 PMID: 26500501

Leal et al (2014) Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neurons. PLoS One 9 e108175 PMID: 25286195

Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. J Neurosci 3 282 PMID: 25254342

Grace et al (2014) Identification of a pharmacological target for genioglossus reactivation throughout sleep. Elife 37 41 PMID: 24470694

Chanda et al (2013) Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. J Biol Chem 110 16622 PMID: 24046374

Shulga et al (2012) The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci 32 1757 PMID: 22302815

Gaamouch et al (2012) Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity. J Neurosci 32 10767 PMID: 22855824

Kaufman et al (2012) Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. Sleep 32 3992 PMID: 22442066

Saliba et al (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. J Neurophysiol 31 2937 PMID: 22531784

Hagiwara et al (2012) Optophysiological analysis of associational circuits in the olfactory cortex. Cell Death Dis 6 18 PMID: 22529781

Fontán-Lozano et al (2011) The A-current modulates learning via NMDA receptors containing the NR2B subunit. PLoS One 6 e24915 PMID: 21966384

Restituito et al (2011) Synaptic autoregulation by metalloproteases and γ-secretase. J Neurosci 31 12083 PMID: 21865451

Gómez-Gonzalo et al (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol 8 e1000352 PMID: 20405049

Sun (2009) Experience-dependent intrinsic plasticity in interneurons of barrel cortex layer IV. EMBO J 102 2955 PMID: 19741102

Léveillé et al (2008) Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J 22 4258 PMID: 18711223

Han et al (2007) Dopaminergic modulation of spinal neuronal excitability. J Neurophysiol 27 13192 PMID: 18045913

Lenz and Avruch (2005) Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. Stem Cell Reports 280 38121 PMID: 16183639


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