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Submit ReviewML 277
Description: Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current
Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for ML 277
ML 277 is a selective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocytes and shortens action potential duration.
Compound Libraries for ML 277
ML 277 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ML 277
| M. Wt | 471.59 |
| Formula | C23H25N3O4S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1401242-74-7 |
| PubChem ID | 53347902 |
| InChI Key | OXQNLLVUVDAEHC-OAQYLSRUSA-N |
| Smiles | O=[C@@]([C@H]3CCCCN3S(C4=CC=C(C)C=C4)(=O)=O)NC1=NC(C2=CC=C(OC)C=C2)=CS1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 277
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.16 | 100 |
Preparing Stock Solutions for ML 277
The following data is based on the product molecular weight 471.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.6 mL | 21.2 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets for ML 277
References for ML 277
References are publications that support the biological activity of the product.
Mattmann et al (2012) Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator. Bioorg.Med.Chem.Lett. 22 5936 PMID: 22910039
Yu et al (2013) Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proc.Natl.Acad.Sci.U.S.A. 110 8732 PMID: 23650380
If you know of a relevant reference for ML 277, please let us know.
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Keywords: ML 277, ML 277 supplier, ML277, kv7.1, channel, activators, activates, KCNQ1, selective, IKs, currents, long, QT, syndrome, LQTS, Voltage-Gated, Potassium, Channels, 4777, Tocris Bioscience
Citations for ML 277
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Currently there are no citations for ML 277. Do you know of a great paper that uses ML 277 from Tocris? Please let us know.
Reviews for ML 277
Average Rating: 5 (Based on 1 Review.)
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ML 277 is a good voltage gated K+ channel activator.
By
Anonymous on 10/23/2018
Assay Type: In Vitro
Species: Human
ML 277 is being used on our lab for its selective channel activation properties. It shows great Kv channel opening properties. Have been used in published papers and the data produced are consistent.
Dissolve in DMSO. For sterile conditions, use sterile DMSO.
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