ML 277

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current
Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)

Biological Activity for ML 277

ML 277 is a selective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocytes and shortens action potential duration.

Compound Libraries for ML 277

ML 277 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 277

M. Wt 471.59
Formula C23H25N3O4S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1401242-74-7
PubChem ID 53347902
InChI Key OXQNLLVUVDAEHC-OAQYLSRUSA-N
Smiles O=[C@@]([C@H]3CCCCN3S(C4=CC=C(C)C=C4)(=O)=O)NC1=NC(C2=CC=C(OC)C=C2)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 277

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.16 100

Preparing Stock Solutions for ML 277

The following data is based on the product molecular weight 471.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.6 mL 21.2 mL
5 mM 0.42 mL 2.12 mL 4.24 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for ML 277

References are publications that support the biological activity of the product.

Mattmann et al (2012) Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator. Bioorg.Med.Chem.Lett. 22 5936 PMID: 22910039

Yu et al (2013) Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proc.Natl.Acad.Sci.U.S.A. 110 8732 PMID: 23650380


If you know of a relevant reference for ML 277, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Activators

Keywords: ML 277, ML 277 supplier, ML277, kv7.1, channel, activators, activates, KCNQ1, selective, IKs, currents, long, QT, syndrome, LQTS, Voltage-Gated, Potassium, Channels, 4777, Tocris Bioscience

Citations for ML 277

Citations are publications that use Tocris products.

Currently there are no citations for ML 277. Do you know of a great paper that uses ML 277 from Tocris? Please let us know.

Reviews for ML 277

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used ML 277?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


ML 277 is a good voltage gated K+ channel activator.
By Anonymous on 10/23/2018
Assay Type: In Vitro
Species: Human

ML 277 is being used on our lab for its selective channel activation properties. It shows great Kv channel opening properties. Have been used in published papers and the data produced are consistent.

Dissolve in DMSO. For sterile conditions, use sterile DMSO.

review image