NS 3623

Pricing Availability   Qty
Description: KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic
Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea
Purity: ≥99% (HPLC)
Reviews (1)
Literature (5)

Biological Activity for NS 3623

NS 3623 is a KV11.1 (hERG) and KV4.3 channel activator. Activates the IKr and Ito currents and displays antiarrhythmic activity. May also act as a partial blocker of KV11.1 channels. Displays selectivity over the key cardiac potassium channels, KV7.1 (KCNQ1) and KV1.5. Suitable for both in vitro and in vivo use.

Compound Libraries for NS 3623

NS 3623 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NS 3623

M. Wt 427.18
Formula C15H10BrF3N6O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 343630-41-1
PubChem ID 9954236
Smiles BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NS 3623

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.72 100

Preparing Stock Solutions for NS 3623

The following data is based on the product molecular weight 427.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.7 mL 23.41 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for NS 3623

References are publications that support the biological activity of the product.

Hansen et al (2006) Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]. Mol.Pharmacol. 70 1319 PMID: 16825484

George (2009) Restoring repolarization in LQT3. Heart Rhythm. 6 107 PMID: 19121809

Hansen et al (2007) Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart. J.Pharmacol.Exp.Ther. 321 996 PMID: 17325228

Calloe et al (2016) A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem.Pharmacol. 108 36 PMID: 27002181

If you know of a relevant reference for NS 3623, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Activators

Keywords: NS 3623, NS 3623 supplier, hERG, activators, cardiac, ether-a-go-go, IKr, Kv11.1, potassium, channels, voltage-gated, Kv, anti-arrhythmic, NS3623, Kv4.3, Ito, Voltage-Gated, Potassium, Channels, 4462, Tocris Bioscience

Citations for NS 3623

Citations are publications that use Tocris products.

Currently there are no citations for NS 3623. Do you know of a great paper that uses NS 3623 from Tocris? Please let us know.

Reviews for NS 3623

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used NS 3623?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Product performs well as a channel opener in experimental conditions.
By Sadequl Islam on 10/12/2018
Assay Type: In Vitro
Species: Human

Product worked amazing on experimental conditions. Shows channel opening properties and must be dissolved in Tween 20–propylene glycol mixture.NS3623 affects the voltage-dependent potassium channel opening.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Ion Channel Product Listing

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Epilepsy Poster

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.

Pain Poster

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.