NS 5806

Pricing Availability Delivery Time Qty
Cat.No. 4166 - NS 5806 | C16H8Br2F6N6O | CAS No. 426834-69-7
Description: KV4.3 channel activator
Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

KV4.3 channel activator; mediates the transient outward K+ current (Ito). Increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM). Inhibits KV1.4-mediated currents independently of KChIP2. Also slows the decay of KV4.2 and KV4.3 currents in the presence of KChIP2.

Compound Libraries

NS 5806 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 574.07
Formula C16H8Br2F6N6O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 426834-69-7
PubChem ID 11642685
InChI Key UZWJWROOLOOCPQ-UHFFFAOYSA-N
Smiles BrC1=CC(Br)=CC(C2=NN=NN2)=C1NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 57.41 100
ethanol 28.7 50

Preparing Stock Solutions

The following data is based on the product molecular weight 574.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.74 mL 8.71 mL 17.42 mL
5 mM 0.35 mL 1.74 mL 3.48 mL
10 mM 0.17 mL 0.87 mL 1.74 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Calloe et al (2009) A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc.Res. 81 686 PMID: 19073629

Calloe et al (2010) Differential effects of the transient outward K+ current activator NS5806 in the canine left ventricle. J.Mol.Cell.Cardiol. 48 191 PMID: 19632239

Lundby et al (2010) Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2. Br.J.Pharmacol. 160 2028 PMID: 20649599


If you know of a relevant reference for NS 5806, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Activators

Keywords: NS5806 kv4.3 channels ito transient outward potassium currents activators voltage-gated voltage-dependent K+ Voltage-Gated Potassium Channels

1 Citation for NS 5806

Citations are publications that use Tocris products. Selected citations for NS 5806 include:

Gonzalez et al (2014) Modulation of the voltage-gated potassium channel (Kv4.3) and the auxiliary protein (KChIP3) interactions by the current activator NS5806. J Biol Chem 289 32201 PMID: 25228688


Do you know of a great paper that uses NS 5806 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for NS 5806

Protocols

TODO: Add Protocols