NS 5806

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Cat.No. 4166 - NS 5806 | C16H8Br2F6N6O | CAS No. 426834-69-7
Description: KV4.3 channel activator
Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature

Biological Activity

KV4.3 channel activator; mediates the transient outward K+ current (Ito). Increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM). Inhibits KV1.4-mediated currents independently of KChIP2. Also slows the decay of KV4.2 and KV4.3 currents in the presence of KChIP2.

Compound Libraries

NS 5806 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 574.07
Formula C16H8Br2F6N6O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 426834-69-7
PubChem ID 11642685
InChI Key UZWJWROOLOOCPQ-UHFFFAOYSA-N
Smiles BrC1=CC(Br)=CC(C2=NN=NN2)=C1NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 57.41 100
ethanol 28.7 50

Preparing Stock Solutions

The following data is based on the product molecular weight 574.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.74 mL 8.71 mL 17.42 mL
5 mM 0.35 mL 1.74 mL 3.48 mL
10 mM 0.17 mL 0.87 mL 1.74 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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References

References are publications that support the biological activity of the product.

Calloe et al (2009) A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc.Res. 81 686 PMID: 19073629

Calloe et al (2010) Differential effects of the transient outward K+ current activator NS5806 in the canine left ventricle. J.Mol.Cell.Cardiol. 48 191 PMID: 19632239

Lundby et al (2010) Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2. Br.J.Pharmacol. 160 2028 PMID: 20649599


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View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Activators

Keywords: NS 5806, NS 5806 supplier, NS5806, kv4.3, channels, ito, transient, outward, potassium, currents, activators, voltage-gated, voltage-dependent, K+, Voltage-Gated, Potassium, Channels, 4166, Tocris Bioscience

1 Citation for NS 5806

Citations are publications that use Tocris products. Selected citations for NS 5806 include:

Gonzalez et al (2014) Modulation of the voltage-gated potassium channel (Kv4.3) and the auxiliary protein (KChIP3) interactions by the current activator NS5806. J Biol Chem 289 32201 PMID: 25228688


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Reviews for NS 5806

Average Rating: 4 (Based on 1 Review.)

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NS 5806 shows channel opening properties and would use this product again.
By Sadequl Islam on 10/12/2018
Assay Type: In Vitro
Species: Human

NS 5806 was studied to understand its channel opening properties. The product was dissolved in DMSO and it showed channel opening properties as expected. Performs well in experimental condition. Would recommend and use again.

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Literature in this Area

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