KV4.3 channel activator; mediates the transient outward K+ current (Ito). Increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM). Inhibits KV1.4-mediated currents independently of KChIP2. Also slows the decay of KV4.2 and KV4.3 currents in the presence of KChIP2.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 574.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.74 mL||8.71 mL||17.42 mL|
|5 mM||0.35 mL||1.74 mL||3.48 mL|
|10 mM||0.17 mL||0.87 mL||1.74 mL|
|50 mM||0.03 mL||0.17 mL||0.35 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Calloe et al (2009) A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc.Res. 81 686 PMID: 19073629
Calloe et al (2010) Differential effects of the transient outward K+ current activator NS5806 in the canine left ventricle. J.Mol.Cell.Cardiol. 48 191 PMID: 19632239
Lundby et al (2010) Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2. Br.J.Pharmacol. 160 2028 PMID: 20649599
If you know of a relevant reference for NS 5806, please let us know.
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Keywords: NS5806 kv4.3 channels ito transient outward potassium currents activators voltage-gated voltage-dependent K+ Voltage-Gated Potassium Channels
1 Citation for NS 5806
Citations are publications that use Tocris products. Selected citations for NS 5806 include:
Gonzalez et al (2014) Modulation of the voltage-gated potassium channel (Kv4.3) and the auxiliary protein (KChIP3) interactions by the current activator NS5806. J Biol Chem 289 32201 PMID: 25228688
Do you know of a great paper that uses NS 5806 from Tocris? If so please let us know.
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