ML 213

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Cat.No. 4519 - ML 213 | C17H23NO | CAS No. 489402-47-3
Description: KV7.2 and KV7.4 channel opener
Chemical Name: N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay.

Compound Libraries

ML 213 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 257.37
Formula C17H23NO
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 489402-47-3
PubChem ID 3111211
InChI Key SIQGKPGBLYKQBB-UHFFFAOYSA-N
Smiles O=C(NC3=C(C)C=C(C)C=C3C)C1CC2CCC1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.87 50
ethanol 12.87 50

Preparing Stock Solutions

The following data is based on the product molecular weight 257.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.89 mL 19.43 mL 38.85 mL
5 mM 0.78 mL 3.89 mL 7.77 mL
10 mM 0.39 mL 1.94 mL 3.89 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yu et al (2011) Discovery, synthesis, and structure activity relationship of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener. ACS Chem.Neurosci. 2 572 PMID: 22125664


If you know of a relevant reference for ML 213, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Activators

Keywords: ML213 KCNQ2 KCNQ4 channels openers kv7.2 kv7.4 potassium K+ voltage gated potassium Kv Voltage-Gated Potassium Channels

1 Citation for ML 213

Citations are publications that use Tocris products. Selected citations for ML 213 include:

Brueggemann et al (2014) Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol.Pharmacol. 86 330 PMID: 24944189


Do you know of a great paper that uses ML 213 from Tocris? If so please let us know.

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Pathways for ML 213

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