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Submit ReviewML 213
Description: KV7.2 and KV7.4 channel opener
Chemical Name: N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide
Purity: ≥99% (HPLC)
Biological Activity for ML 213
ML 213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Hyperpolarizes resting membrane potential in an in vitro spinal cord preparation.
Compound Libraries for ML 213
ML 213 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ML 213
| M. Wt | 257.37 |
| Formula | C17H23NO |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 489402-47-3 |
| PubChem ID | 3111211 |
| InChI Key | SIQGKPGBLYKQBB-UHFFFAOYSA-N |
| Smiles | O=C(NC3=C(C)C=C(C)C=C3C)C1CC2CCC1C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 213
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.87 | 50 | |
| ethanol | 12.87 | 50 |
Preparing Stock Solutions for ML 213
The following data is based on the product molecular weight 257.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.77 mL | 38.85 mL | 77.71 mL |
| 2.5 mM | 1.55 mL | 7.77 mL | 15.54 mL |
| 5 mM | 0.78 mL | 3.89 mL | 7.77 mL |
| 25 mM | 0.16 mL | 0.78 mL | 1.55 mL |
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Product Datasheets for ML 213
References for ML 213
References are publications that support the biological activity of the product.
Yu et al (2011) Discovery, synthesis, and structure activity relationship of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener. ACS Chem.Neurosci. 2 572 PMID: 22125664
Vicente-Baz et al (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109 131 PMID: 27263036
If you know of a relevant reference for ML 213, please let us know.
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Keywords: ML 213, ML 213 supplier, ML213, KCNQ2, KCNQ4, channels, openers, kv7.2, kv7.4, potassium, K+, voltage, gated, Kv, Voltage-Gated, Potassium, Channels, 4519, Tocris Bioscience
2 Citations for ML 213
Citations are publications that use Tocris products. Selected citations for ML 213 include:
Vincente-Baz et al (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109 131 PMID: 27263036
Brueggemann et al (2014) Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol.Pharmacol. 86 330 PMID: 24944189
Do you know of a great paper that uses ML 213 from Tocris? Please let us know.
Reviews for ML 213
Average Rating: 5 (Based on 1 Review.)
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ML 213 was used to study Kv11.1 channel activation.
By
Sadequl Islam on 11/07/2018
Assay Type: In Vitro
Species: Human
ML 213 was recently used to understand its effect on Kv11.1 and overall voltage gating mechanism. Different level of activation was observed.
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