ML 213

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Description: KV7.2 and KV7.4 channel opener
Chemical Name: N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews (1)

Biological Activity for ML 213

ML 213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Hyperpolarizes resting membrane potential in an in vitro spinal cord preparation.

Compound Libraries for ML 213

ML 213 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 213

M. Wt 257.37
Formula C17H23NO
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 489402-47-3
PubChem ID 3111211
InChI Key SIQGKPGBLYKQBB-UHFFFAOYSA-N
Smiles O=C(NC3=C(C)C=C(C)C=C3C)C1CC2CCC1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 213

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.87 50
ethanol 12.87 50

Preparing Stock Solutions for ML 213

The following data is based on the product molecular weight 257.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.77 mL 38.85 mL 77.71 mL
2.5 mM 1.55 mL 7.77 mL 15.54 mL
5 mM 0.78 mL 3.89 mL 7.77 mL
25 mM 0.16 mL 0.78 mL 1.55 mL

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References for ML 213

References are publications that support the biological activity of the product.

Yu et al (2011) Discovery, synthesis, and structure activity relationship of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener. ACS Chem.Neurosci. 2 572 PMID: 22125664

Vicente-Baz et al (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109 131 PMID: 27263036


If you know of a relevant reference for ML 213, please let us know.

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Keywords: ML 213, ML 213 supplier, ML213, KCNQ2, KCNQ4, channels, openers, kv7.2, kv7.4, potassium, K+, voltage, gated, Kv, Voltage-Gated, Potassium, Channels, 4519, Tocris Bioscience

2 Citations for ML 213

Citations are publications that use Tocris products. Selected citations for ML 213 include:

Vincente-Baz et al (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109 131 PMID: 27263036

Brueggemann et al (2014) Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol.Pharmacol. 86 330 PMID: 24944189


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Reviews for ML 213

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ML 213 was used to study Kv11.1 channel activation.
By Sadequl Islam on 11/07/2018
Assay Type: In Vitro
Species: Human

ML 213 was recently used to understand its effect on Kv11.1 and overall voltage gating mechanism. Different level of activation was observed.

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