ML 213

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: KV7.2 and KV7.4 channel opener
Chemical Name: N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide
Purity: ≥99% (HPLC)
Citations (2)
Reviews (1)

Biological Activity for ML 213

ML 213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Hyperpolarizes resting membrane potential in an in vitro spinal cord preparation.

Compound Libraries for ML 213

ML 213 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 213

M. Wt 257.37
Formula C17H23NO
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 489402-47-3
PubChem ID 3111211
Smiles O=C(NC3=C(C)C=C(C)C=C3C)C1CC2CCC1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 213

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 12.87 50
ethanol 12.87 50

Preparing Stock Solutions for ML 213

The following data is based on the product molecular weight 257.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.77 mL 38.85 mL 77.71 mL
2.5 mM 1.55 mL 7.77 mL 15.54 mL
5 mM 0.78 mL 3.89 mL 7.77 mL
25 mM 0.16 mL 0.78 mL 1.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for ML 213

References are publications that support the biological activity of the product.

Yu et al (2011) Discovery, synthesis, and structure activity relationship of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener. ACS Chem.Neurosci. 2 572 PMID: 22125664

Vicente-Baz et al (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109 131 PMID: 27263036

If you know of a relevant reference for ML 213, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Activators

Keywords: ML 213, ML 213 supplier, ML213, KCNQ2, KCNQ4, channels, openers, kv7.2, kv7.4, potassium, K+, voltage, gated, Kv, Voltage-Gated, Potassium, Channels, 4519, Tocris Bioscience

2 Citations for ML 213

Citations are publications that use Tocris products. Selected citations for ML 213 include:

Vincente-Baz et al (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109 131 PMID: 27263036

Brueggemann et al (2014) Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol.Pharmacol. 86 330 PMID: 24944189

Do you know of a great paper that uses ML 213 from Tocris? Please let us know.

Reviews for ML 213

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used ML 213?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

ML 213 was used to study Kv11.1 channel activation.
By Sadequl Islam on 11/07/2018
Assay Type: In Vitro
Species: Human

ML 213 was recently used to understand its effect on Kv11.1 and overall voltage gating mechanism. Different level of activation was observed.

review image