QO 58

Pricing Availability   Qty
Cat.No. 5083 - QO 58 | C18H8Cl2F4N4O | CAS No. 1259536-62-3
Description: Kv7 channel opener
Chemical Name: 5-(2,6-Dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model.

Technical Data

M. Wt 443.18
Formula C18H8Cl2F4N4O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1259536-62-3
PubChem ID 51351551
InChI Key ZOLHKPWSDFSDKA-UHFFFAOYSA-N
Smiles O=C1C=C(C4=CC(F)=C(Cl)N=C4Cl)NC2=C(C3=CC=CC=C3)C(C(F)(F)F)=NN12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.16 50

Preparing Stock Solutions

The following data is based on the product molecular weight 443.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.51 mL 22.56 mL 45.13 mL
2.5 mM 0.9 mL 4.51 mL 9.03 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
25 mM 0.09 mL 0.45 mL 0.9 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Zhang et al (2013) Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br.J.Pharmacol. 168 1030 PMID: 23013484

Qi et al (2011) Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. Eur.J.Med.Chem. 46 934 PMID: 21296466


If you know of a relevant reference for QO 58, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Activators

Keywords: QO 58, QO 58 supplier, Kv7, openers, K+, channel, activators, voltage, gated, potassium, channels, neuropathic, pain, Voltage-Gated, Potassium, Channels, 5083, Tocris Bioscience

Citations for QO 58

Citations are publications that use Tocris products.

Currently there are no citations for QO 58. Do you know of a great paper that uses QO 58 from Tocris? Please let us know.

Reviews for QO 58

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used QO 58?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


QO 58 used for to understand channel opening properties
By Anonymous on 10/13/2018
Assay Type: In Vitro
Species: Human

Our University lab used this product for years to study channel opening properties. Worked great on lab conditions and shows different rates on channel opening on different cell lines. Great product, would buy again and recommend.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Epilepsy

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.