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Biological Activity for QO 58
QO 58 is a Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model.
Compound Libraries for QO 58
Technical Data for QO 58
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for QO 58
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for QO 58
The following data is based on the product molecular weight 443.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.51 mL||22.56 mL||45.13 mL|
|2.5 mM||0.9 mL||4.51 mL||9.03 mL|
|5 mM||0.45 mL||2.26 mL||4.51 mL|
|25 mM||0.09 mL||0.45 mL||0.9 mL|
References for QO 58
References are publications that support the biological activity of the product.
Zhang et al (2013) Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br.J.Pharmacol. 168 1030 PMID: 23013484
Qi et al (2011) Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. Eur.J.Med.Chem. 46 934 PMID: 21296466
If you know of a relevant reference for QO 58, please let us know.
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Citations for QO 58
Citations are publications that use Tocris products.
Currently there are no citations for QO 58. Do you know of a great paper that uses QO 58 from Tocris? Please let us know.
Reviews for QO 58
Average Rating: 5 (Based on 1 Review.)
Have you used QO 58?
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Our University lab used this product for years to study channel opening properties. Worked great on lab conditions and shows different rates on channel opening on different cell lines. Great product, would buy again and recommend.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.