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Potassium Channels

Potassium channels are crucial regulators of membrane excitability. They control the frequency and shape of action potentials, regulate secretion of hormones and neurotransmitters and establish cell plasma membrane potential. This large family can be regulated by voltage, Ca2+, neurotransmitters and the signaling pathways that they stimulate. Structurally, potassium channels exist as tetramers and the pore forming entity is the α-subunit. There are more than 70 different genes encoding the K+ α-subunit in the human genome.

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Literature
Ion Channel Data

Potassium Channel Target Files

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The Proposed Structure of Voltage-Gated Potassium Channels


The figure below shows the proposed structure of voltage-gated potassium channels.

A single α subunit

A. A single α subunit showing the K+ ion selectivity signature motif 'T/SxxTxGYG' within the pore loop.

The general assembly of the K<sup>+</sup> channel

B. The general assembly of the K+ channel; composed of four, P loop-containing α-subunits arranged in a tetrameric fashion.

The table below summarizes the key characteristics of some potassium channels.

Literature for Potassium Channels

Tocris offers the following scientific literature for Potassium Channels to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular

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Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Properties of Potassium Channels

Type Inward Rectifier ATP-Sensitive Voltage-Sensitive Ca2+-Activated
Subtype - - A-type Delayed rectifier Large conductance (maxi-K, BK) Small conductance (SK)
Effect of Ca2+ Insensitive Insensitive Insensitive Insensitive Variable High sensitivity
Effect of Voltage Strong, inward rectification Weak, inward rectification Sensitive Sensitive Sensitive Insensitive
Effect of ATP Insensitive Inhibits channel opening Insensitive Insensitive Insensitive Insensitive
Conductance (pS) 5-30 5-90 < 1-20 < 1-20 100-250 6-14

References

Robertson et al (1997) The real life of voltage-gated K+ channels: more than model behaviour. TiPS 18 474. Mathie et al (1998) Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents. Gen.Pharmacol. 30 13. Vergara et al (1998) Calcium-activated potassium channels. Curr.Opin.Neurobiol. 8 321.

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