Selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 269.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.71 mL||18.54 mL||37.09 mL|
|5 mM||0.74 mL||3.71 mL||7.42 mL|
|10 mM||0.37 mL||1.85 mL||3.71 mL|
|50 mM||0.07 mL||0.37 mL||0.74 mL|
References are publications that support the biological activity of the product.
Amato et al (2011) N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med.Chem.Lett. 2 481 PMID: 24900334
Provence et al (2015) The novel Kv7.2/Kv7.3 channel opener ICA-069673 reveals subtype-specific functional roles in guinea pig detrusor smooth muscle excitability and contractility. J.Pharmacol.Exp.Ther. 354 290 PMID: 26087697
If you know of a relevant reference for ICA 069673, please let us know.
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Keywords: ICA 069673, ICA 069673 supplier, ICA069673, KCNQ2, KCNQ3, kv7.2, kv7.3, channel, opener, potassium, K+, voltage, gated, openers, Kv, Voltage-Gated, Potassium, Channels, 4305, Tocris Bioscience
2 Citations for ICA 069673
Citations are publications that use Tocris products. Selected citations for ICA 069673 include:
Brueggemann et al (2014) Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol.Pharmacol. 2014 330 PMID: 24944189
Vicente-Baz et al (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109 131 PMID: 27263036
Do you know of a great paper that uses ICA 069673 from Tocris? Please let us know.
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ICA 069673 was used to study Kv channel opening on brain tissues of rodents. It shows variable but big % of channel opening.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.