ICA 069673

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Cat.No. 4305 - ICA 069673 | C11H6ClF2N3O | CAS No. 582323-16-8
Description: KV7.2/KV7.3 channel opener
Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

Compound Libraries

ICA 069673 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 269.63
Formula C11H6ClF2N3O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 582323-16-8
PubChem ID 10149311
InChI Key IIBSHMFXVWTQSJ-UHFFFAOYSA-N
Smiles ClC1=NC=C(NC(C2=CC(F)=C(F)C=C2)=O)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.96 100
ethanol 6.74 25

Preparing Stock Solutions

The following data is based on the product molecular weight 269.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.54 mL 37.09 mL
5 mM 0.74 mL 3.71 mL 7.42 mL
10 mM 0.37 mL 1.85 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Amato et al (2011) N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med.Chem.Lett. 2 481 PMID: 4900334

Provence et al (2015) The novel Kv7.2/Kv7.3 channel opener ICA-069673 reveals subtype-specific functional roles in guinea pig detrusor smooth muscle excitability and contractility. J.Pharmacol.Exp.Ther. 354 290 PMID: 26087697


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View all Voltage-gated Potassium (KV) Channel Activators

Keywords: ICA069673 KCNQ2 KCNQ3 kv7.2 kv7.3 channel opener potassium K+ voltage gated potassium channel openers Kv Voltage-Gated Potassium Channels

1 Citation for ICA 069673

Citations are publications that use Tocris products. Selected citations for ICA 069673 include:

Brueggemann et al (2014) Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol.Pharmacol. 2014 330 PMID: 24944189


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