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Submit ReviewICA 069673
Description: KV7.2/KV7.3 channel opener
Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
Purity: ≥99% (HPLC)
Biological Activity for ICA 069673
ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.
Compound Libraries for ICA 069673
ICA 069673 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ICA 069673
| M. Wt | 269.63 |
| Formula | C11H6ClF2N3O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 582323-16-8 |
| PubChem ID | 10149311 |
| InChI Key | IIBSHMFXVWTQSJ-UHFFFAOYSA-N |
| Smiles | ClC1=NC=C(NC(C2=CC(F)=C(F)C=C2)=O)C=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ICA 069673
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.96 | 100 | |
| ethanol | 6.74 | 25 |
Preparing Stock Solutions for ICA 069673
The following data is based on the product molecular weight 269.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.71 mL | 18.54 mL | 37.09 mL |
| 5 mM | 0.74 mL | 3.71 mL | 7.42 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets for ICA 069673
References for ICA 069673
References are publications that support the biological activity of the product.
Amato et al (2011) N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med.Chem.Lett. 2 481 PMID: 24900334
Provence et al (2015) The novel Kv7.2/Kv7.3 channel opener ICA-069673 reveals subtype-specific functional roles in guinea pig detrusor smooth muscle excitability and contractility. J.Pharmacol.Exp.Ther. 354 290 PMID: 26087697
If you know of a relevant reference for ICA 069673, please let us know.
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Keywords: ICA 069673, ICA 069673 supplier, ICA069673, KCNQ2, KCNQ3, kv7.2, kv7.3, channel, opener, potassium, K+, voltage, gated, openers, Kv, Voltage-Gated, Potassium, Channels, 4305, Tocris Bioscience
2 Citations for ICA 069673
Citations are publications that use Tocris products. Selected citations for ICA 069673 include:
Brueggemann et al (2014) Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol.Pharmacol. 2014 330 PMID: 24944189
Vicente-Baz et al (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109 131 PMID: 27263036
Do you know of a great paper that uses ICA 069673 from Tocris? Please let us know.
Reviews for ICA 069673
Average Rating: 5 (Based on 1 Review.)
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ICA 069673 was used to study Kv channel opening on brain tissues of rodents.
By
Eleanor Baxter on 10/23/2018
Assay Type: In Vitro
Species: Rat
ICA 069673 was used to study Kv channel opening on brain tissues of rodents. It shows variable but big % of channel opening.
Literature in this Area
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