Enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM).
Racemate also available.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||32.44||100 with gentle warming|
|DMSO||32.44||100 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 324.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.08 mL||15.41 mL||30.83 mL|
|5 mM||0.62 mL||3.08 mL||6.17 mL|
|10 mM||0.31 mL||1.54 mL||3.08 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References are publications that support the biological activity of the product.
Lerche et al (2001) Molecular impact of MinK on the enantiospecific block of IKs by chromanols. Br.J.Pharmacol. 131 1503 PMID: 11139424
Seebohm et al (2001) A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B. Br.J.Pharmacol. 134 1647 PMID: 11739240
Yang et al (2000) Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 294 955 PMID: 10945846
If you know of a relevant reference for (-)-[3R,4S]-Chromanol 293B, please let us know.
View Related Products by Product Action
Keywords: (-)-[3R,4S]-Chromanol 293B, (-)-[3R,4S]-Chromanol 293B supplier, IKs, blockers, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, (-)-[3R4S]-Chromanol293B, Voltage-Gated, 1475, Tocris Bioscience
2 Citations for (-)-[3R,4S]-Chromanol 293B
Citations are publications that use Tocris products. Selected citations for (-)-[3R,4S]-Chromanol 293B include:
Ma et al (2011) High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. FASEB J 301 H2006 PMID: 21890694
Purtell et al (2012) The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake. Neuropharmacology 26 3252 PMID: 22549510
Do you know of a great paper that uses (-)-[3R,4S]-Chromanol 293B from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.