You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for (-)-[3R,4S]-Chromanol 293B
(-)-[3R,4S]-Chromanol 293B is a enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM).
Racemate also available.
Compound Libraries for (-)-[3R,4S]-Chromanol 293B
Technical Data for (-)-[3R,4S]-Chromanol 293B
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (-)-[3R,4S]-Chromanol 293B
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||32.44||100 with gentle warming|
|DMSO||32.44||100 with gentle warming|
Preparing Stock Solutions for (-)-[3R,4S]-Chromanol 293B
The following data is based on the product molecular weight 324.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.08 mL||15.41 mL||30.83 mL|
|5 mM||0.62 mL||3.08 mL||6.17 mL|
|10 mM||0.31 mL||1.54 mL||3.08 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
Product Datasheets for (-)-[3R,4S]-Chromanol 293B
References for (-)-[3R,4S]-Chromanol 293B
References are publications that support the biological activity of the product.
Lerche et al (2001) Molecular impact of MinK on the enantiospecific block of IKs by chromanols. Br.J.Pharmacol. 131 1503 PMID: 11139424
Seebohm et al (2001) A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B. Br.J.Pharmacol. 134 1647 PMID: 11739240
Yang et al (2000) Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 294 955 PMID: 10945846
If you know of a relevant reference for (-)-[3R,4S]-Chromanol 293B, please let us know.
View Related Products by Product Action
Keywords: (-)-[3R,4S]-Chromanol 293B, (-)-[3R,4S]-Chromanol 293B supplier, IKs, blockers, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, (-)-[3R4S]-Chromanol293B, Voltage-Gated, 1475, Tocris Bioscience
3 Citations for (-)-[3R,4S]-Chromanol 293B
Citations are publications that use Tocris products. Selected citations for (-)-[3R,4S]-Chromanol 293B include:
Song et al (2022) Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat.Card.Res. 1 142
Ma et al (2011) High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. FASEB J 301 H2006 PMID: 21890694
Purtell et al (2012) The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake. Neuropharmacology 26 3252 PMID: 22549510
Do you know of a great paper that uses (-)-[3R,4S]-Chromanol 293B from Tocris? Please let us know.
Reviews for (-)-[3R,4S]-Chromanol 293B
There are currently no reviews for this product. Be the first to review (-)-[3R,4S]-Chromanol 293B and earn rewards!
Have you used (-)-[3R,4S]-Chromanol 293B?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.