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Non-selective K+ channel blocker.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 165.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.05 mL||30.27 mL||60.53 mL|
|5 mM||1.21 mL||6.05 mL||12.11 mL|
|10 mM||0.61 mL||3.03 mL||6.05 mL|
|50 mM||0.12 mL||0.61 mL||1.21 mL|
References are publications that support the biological activity of the product.
Niu et al (2008) Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. Eur.J.Pharmacol. 580 169 PMID: 17997400
If you know of a relevant reference for Tetraethylammonium chloride, please let us know.
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Keywords: Tetraethylammonium chloride, Tetraethylammonium chloride supplier, Non-Selective, K+, channels, blockers, Potassium, TEA, Voltage-Gated, Channels, 3068, Tocris Bioscience
7 Citations for Tetraethylammonium chloride
Citations are publications that use Tocris products. Selected citations for Tetraethylammonium chloride include:
Borgs et al (2016) DArgic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects. Scientific Reports 6 33377 PMID: 27640816
Collins et al (2018) Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. Neuron 98 366 PMID: 29628187
Lerner et al (2010) Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. J Neurosci 30 2160 PMID: 20147543
Zhang et al (2019) A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells. J Biol Chem PMID: 30792309
Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. Sleep 3 282 PMID: 25254342
Grace et al (2014) Identification of a pharmacological target for genioglossus reactivation throughout sleep. Iran J Pharm Res 37 41 PMID: 24470694
Chanda et al (2013) Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. Stem Cell Reports 110 16622 PMID: 24046374
Do you know of a great paper that uses Tetraethylammonium chloride from Tocris? Please let us know.
Reviews for Tetraethylammonium chloride
Average Rating: 5 (Based on 1 Review.)
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Tetraethylammonium was used to identify percentage blocking on potassium channel.The product shows relatively low blocking action on potassium channels. It works good on sterile conditions and the data pattern is quite similar.
Literature in this Area
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.