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Description: Blocker of KV1.5 channel and IKur current
Alternative Names: Diphenyl phosphine oxide-1
Chemical Name: [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide
Purity: ≥99% (HPLC)
Citations (5)
Reviews (1)

Biological Activity for DPO-1

DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

Technical Data for DPO-1

M. Wt 340.44
Formula C22H29OP
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 43077-30-1
PubChem ID 21678144
Smiles C[C@@H]1CC[C@@H]([C@@H](C)C)[C@@H]([P@@](C2=CC=CC=C2)(C3=CC=CC=C3)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DPO-1

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 34.04 100

Preparing Stock Solutions for DPO-1

The following data is based on the product molecular weight 340.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.37 mL
5 mM 0.59 mL 2.94 mL 5.87 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets for DPO-1

Certificate of Analysis / Product Datasheet
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References for DPO-1

References are publications that support the biological activity of the product.

Stump et al (2005) In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J.Pharmacol.Exp.Ther. 315 1362 PMID: 16157659

Regan et al (2006) In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate. J.Pharmacol.Exp.Ther. 316 727 PMID: 16243963

Lagrutta et al (2006) Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapid activating delayed rectifier potassium current. J.Pharmacol.Exp.Ther. 317 1054 PMID: 16522807

If you know of a relevant reference for DPO-1, please let us know.

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Keywords: DPO-1, DPO-1 supplier, blockers, KV15, channel, IKur, current, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, Diphenylphosphine, oxide1, Diphenyl, phosphine, oxide-1, Voltage-Gated, 2533, Tocris Bioscience

5 Citations for DPO-1

Citations are publications that use Tocris products. Selected citations for DPO-1 include:

Ryland et al (2016) Promoter Methylation Analysis Reveals That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation. Mol Cancer Res 14 26 PMID: 26573141

Tabarean (2014) Electrical remodeling of preoptic GABAergic neurons involves the Kv1.5 subunit. Pharmacol Res Perspect 9 e96643 PMID: 24797243

Ryland et al (2015) Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress. Oncogene 34 4591 PMID: 25435365

Zhao et al (2013) Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells. PLoS One 8 e64629 PMID: 23717641

Do you know of a great paper that uses DPO-1 from Tocris? Please let us know.

Reviews for DPO-1

Average Rating: 5 (Based on 1 Review.)

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DPO 1 was used to investigate its effect on Kv channels at different concentrations.
By Anonymous on 10/29/2018
Assay Type: In Vitro
Species: Human

DPO 1 was used to investigate its effect on Kv channels at different concentrations. Its shows increasing blocking effect on the channels with increasing concentrations. Worked ideally during the study and would recommend the product.

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