DPO-1

Pricing Availability   Qty
Cat.No. 2533 - DPO-1 | C22H29OP | CAS No. 43077-30-1
Description: Blocker of KV1.5 channel and IKur current
Alternative Names: Diphenyl phosphine oxide-1
Chemical Name: [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews (1)
Literature

Biological Activity

Blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

Technical Data

M. Wt 340.44
Formula C22H29OP
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 43077-30-1
PubChem ID 21678144
InChI Key BPCNGVCAHAIZEE-COPCDDAFSA-N
Smiles C[C@@H]1CC[C@@H]([C@@H](C)C)[C@@H]([P@@](C2=CC=CC=C2)(C3=CC=CC=C3)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 34.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 340.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.37 mL
5 mM 0.59 mL 2.94 mL 5.87 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Stump et al (2005) In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J.Pharmacol.Exp.Ther. 315 1362 PMID: 16157659

Regan et al (2006) In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate. J.Pharmacol.Exp.Ther. 316 727 PMID: 16243963

Lagrutta et al (2006) Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapid activating delayed rectifier potassium current. J.Pharmacol.Exp.Ther. 317 1054 PMID: 16522807


If you know of a relevant reference for DPO-1, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Blockers

Keywords: DPO-1, DPO-1 supplier, blockers, KV15, channel, IKur, current, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, Diphenylphosphine, oxide1, Diphenyl, phosphine, oxide-1, Voltage-Gated, 2533, Tocris Bioscience

4 Citations for DPO-1

Citations are publications that use Tocris products. Selected citations for DPO-1 include:

Zhao et al (2013) Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells. PLoS One 8 e64629 PMID: 23717641

Haim et al (2010) Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents. J Mol Cell Cardiol 48 395 PMID: 19857498

Ryland et al (2015) Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress. Oncogene 34 4591 PMID: 25435365

Tabarean (2014) Electrical remodeling of preoptic GABAergic neurons involves the Kv1.5 subunit. Pharmacol Res Perspect 9 e96643 PMID: 24797243


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Reviews for DPO-1

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DPO 1 was used to investigate its effect on Kv channels at different concentrations
By Anonymous on 10/29/2018
Assay Type: In Vitro
Species: Human

DPO 1 was used to investigate its effect on Kv channels at different concentrations. Its shows increasing blocking effect on the channels with increasing concentrations. Worked ideally during the study and would recommend the product.

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Literature in this Area

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