KN 92

Pricing Availability   Qty
Description: Inactive analog of KN 93. K+ channel (Kv) blocker
Chemical Name: 2-[N-(4'-Methoxybenzenesulfonyl)]amino-N-(4'-chlorophenyl)-2-propenyl-N-methylbenzylamine phosphate
Purity: ≥98% (HPLC)
Citations (5)
Reviews (1)

Biological Activity for KN 92

KN 92 is an inactive analog of the CaM kinase II inhibitor KN 93 . Potassium channel (Kv1.2, 1.4, 1.5, 2.1, 3.2 and hERG) blocker in vitro.

Active Analog also available.

Technical Data for KN 92

M. Wt 554.98
Formula C24H25ClN2O3S.H3PO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1135280-28-2
PubChem ID 16219540
Smiles ClC1=CC=C(/C=C/CN(C)CC2=CC=CC=C2NS(=O)(C3=CC=C(OC)C=C3)=O)C=C1.OP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KN 92

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.55 10

Preparing Stock Solutions for KN 92

The following data is based on the product molecular weight 554.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.02 mL 90.09 mL 180.19 mL
0.5 mM 3.6 mL 18.02 mL 36.04 mL
1 mM 1.8 mL 9.01 mL 18.02 mL
5 mM 0.36 mL 1.8 mL 3.6 mL

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References for KN 92

References are publications that support the biological activity of the product.

Rezazadeh et al (2005) KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 317 292 PMID: 16368898

If you know of a relevant reference for KN 92, please let us know.

Keywords: KN 92, KN 92 supplier, potassium, K+, blockers, Kv, channels, inactive, analog, KN93, KN92, calcium, binding, protein, modulators, voltage-gated, hERG, Human, Ether-A-Go-Go, Gene, voltage-dependent, CaM, Kinase, II, kinases, Calmodulin-Activated, calmodulin-dependent, Ca2+, Binding, Calcium, Protein, Voltage-Gated, Potassium, Channels, 4130, Tocris Bioscience

5 Citations for KN 92

Citations are publications that use Tocris products. Selected citations for KN 92 include:

Hongwei et al (2020) Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models. Sci Transl Med 12 PMID: 32641489

Seto et al (2013) Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes. Oncotarget 8 e66404 PMID: 23799098

Thomas et al (2021) Amyloid-Beta Mediates Homeostatic Synaptic Plasticity. J Neurosci 41 5157-5172 PMID: 33926999

Kurt F et al (2019) Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKIIβ-GSK3β interactions. J Neurochem 149 98-110 PMID: 30674062

Weng et al (2017) An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron 94 337 PMID: 28426967

Do you know of a great paper that uses KN 92 from Tocris? Please let us know.

Reviews for KN 92

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KN93 but not KN92 reduces maximum upstroke velocity of cardiac action potential.
By Christopher Trummer on 10/22/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: Cardiomyocytes

Guinea pig ventricular cardiomyocytes were treated (12-16 h) with KN93 (5 µM), KN92 (5 µM) or Ranolazine (10 µM). Cells were patched and stimulated at a 1 Hz frequency to record action potential. Maximum upstroke velocity was significantly was reduced by KN93 while KN92 was ineffective.

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