You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Inactive analog of the CaM kinase II inhibitor KN 93 . Potassium channel (Kv1.2, 1.4, 1.5, 2.1, 3.2 and hERG) blocker in vitro.
Active Analog also available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 554.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||18.02 mL||90.09 mL||180.19 mL|
|0.5 mM||3.6 mL||18.02 mL||36.04 mL|
|1 mM||1.8 mL||9.01 mL||18.02 mL|
|5 mM||0.36 mL||1.8 mL||3.6 mL|
References are publications that support the biological activity of the product.
Rezazadeh et al (2005) KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 317 292 PMID: 16368898
If you know of a relevant reference for KN 92, please let us know.
View Related Products by Target
Keywords: KN 92, KN 92 supplier, potassium, K+, blockers, Kv, channels, inactive, analog, KN93, KN92, calcium, binding, protein, modulators, voltage-gated, hERG, Human, Ether-A-Go-Go, Gene, voltage-dependent, CaM, Kinase, II, kinases, Calmodulin-Activated, calmodulin-dependent, Ca2+, Binding, Calcium, Protein, Voltage-Gated, Potassium, Channels, 4130, Tocris Bioscience
2 Citations for KN 92
Citations are publications that use Tocris products. Selected citations for KN 92 include:
Seto et al (2013) Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes. Oncotarget 8 e66404 PMID: 23799098
Weng et al (2017) An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron 94 337 PMID: 28426967
Do you know of a great paper that uses KN 92 from Tocris? Please let us know.
Reviews for KN 92
Average Rating: 5 (Based on 1 Review.)
Have you used KN 92?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Guinea pig ventricular cardiomyocytes were treated (12-16 h) with KN93 (5 µM), KN92 (5 µM) or Ranolazine (10 µM). Cells were patched and stimulated at a 1 Hz frequency to record action potential. Maximum upstroke velocity was significantly was reduced by KN93 while KN92 was ineffective.