KN 92

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Cat.No. 4130 - KN 92 | C24H25ClN2O3S.H3PO4 | CAS No. 1135280-28-2
Description: Inactive analog of KN 93. K+ channel (Kv) blocker
Chemical Name: 2-[N-(4'-Methoxybenzenesulfonyl)]amino-N-(4'-chlorophenyl)-2-propenyl-N-methylbenzylamine phosphate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)

Biological Activity

Inactive analog of the CaM kinase II inhibitor KN 93 (Cat. No. 1278). Potassium channel (Kv1.2, 1.4, 1.5, 2.1, 3.2 and hERG) blocker in vitro.

Technical Data

M. Wt 554.98
Formula C24H25ClN2O3S.H3PO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1135280-28-2
PubChem ID 16219540
InChI Key XRQHWVVDNMJDEQ-IPZCTEOASA-N
Smiles ClC1=CC=C(/C=C/CN(C)CC2=CC=CC=C2NS(=O)(C3=CC=C(OC)C=C3)=O)C=C1.OP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.55 10

Preparing Stock Solutions

The following data is based on the product molecular weight 554.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.8 mL 9.01 mL 18.02 mL
5 mM 0.36 mL 1.8 mL 3.6 mL
10 mM 0.18 mL 0.9 mL 1.8 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rezazadeh et al (2005) N-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 317 292 PMID: 16368898


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Keywords: KN 92, supplier, potassium, K+, blockers, Kv, channels, inactive, analog, KN93, KN92, calcium, binding, protein, modulators, voltage-gated, hERG, Human, Ether-A-Go-Go, Gene, voltage-dependent, CaM, Kinase, II, kinases, Calmodulin-Activated, calmodulin-dependent, Ca2+, Binding, modulators, Calcium, Binding, Protein, Modulators, Tocris Bioscience

1 Citation for KN 92

Citations are publications that use Tocris products. Selected citations for KN 92 include:

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Oncotarget 8 e66404 PMID: 23799098


Do you know of a great paper that uses KN 92 from Tocris? If so please let us know.

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