Fluticasone propionate

Pricing Availability   Qty
Description: Selective high affinity glucocorticoid receptor agonist
Chemical Name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Fluticasone propionate

Fluticasone propionate is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for Fluticasone propionate

Fluticasone propionate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Fluticasone propionate

M. Wt 500.57
Formula C25H31F3O5S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 80474-14-2
PubChem ID 444036
Smiles O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@](C(SCF)=O)4OC(CC)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Fluticasone propionate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.03 50

Preparing Stock Solutions for Fluticasone propionate

The following data is based on the product molecular weight 500.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4 mL 19.98 mL 39.95 mL
2.5 mM 0.8 mL 4 mL 7.99 mL
5 mM 0.4 mL 2 mL 4 mL
25 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets for Fluticasone propionate

Certificate of Analysis / Product Datasheet
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References for Fluticasone propionate

References are publications that support the biological activity of the product.

Johnson (1995) The anti-inflammatory profile of flutic. propionate. Allergy 50 11 PMID: 7604948

Zhang et al (2000) Enhancement of human eosinophil apoptosis by flutic. propionate, budesonide, and beclometh. Eur.J.Pharmacol. 406 325 PMID: 11040338

Smith and Kreutner (1998) In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneim.-Forsch. 48 956

Pan et al (2012) Potentiation of the Kv1 family K+ channel by cortisone analogues. ACS Chem.Biol. 7 1641 PMID: 22803826

If you know of a relevant reference for Fluticasone propionate, please let us know.

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Keywords: Fluticasone propionate, Fluticasone propionate supplier, Selective, high, affinity, glucocorticoid, agonists, Receptors, GlaxoSmithKline, GSK, Glucocorticoid, Receptor, Voltage-Gated, Potassium, Channels, 2007, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Fluticasone propionate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Fluticasone propionate

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Literature in this Area

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.