Fluticasone propionate

Pricing Availability Delivery Time Qty
Cat.No. 2007 - Fluticasone propionate | C25H31F3O5S | CAS No. 80474-14-2
Description: Selective high affinity glucocorticoid receptor agonist
Chemical Name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries

Fluticasone propionate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 500.57
Formula C25H31F3O5S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 80474-14-2
PubChem ID 444036
InChI Key WMWTYOKRWGGJOA-CENSZEJFSA-N
Smiles O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@](C(SCF)=O)4OC(CC)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.03 50

Preparing Stock Solutions

The following data is based on the product molecular weight 500.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Johnson (1995) The anti-inflammatory profile of fluticasone propionate. Allergy 50 11 PMID: 7604948

Zhang et al (2000) Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone. Eur.J.Pharmacol. 406 325 PMID: 11040338

Smith and Kreutner (1998) In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneim.-Forsch. 48 956 PMID:

Pan et al (2012) Potentiation of the Kv1 family K+ channel by cortisone analogues. ACS Chem.Biol. 7 1641 PMID: 22803826


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Keywords: Fluticasone propionate, supplier, Selective, high, affinity, glucocorticoid, agonists, Receptors, GlaxoSmithKline, GSK, Glucocorticoid, Receptor, Voltage-Gated, Potassium, Channels, Glucocorticoid, Receptor, Tocris Bioscience

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