Home / Pharmacology / Ion Channels / Potassium Channels / Voltage-gated Potassium (KV) Channels / Voltage-gated Potassium (KV) Channel Activators / ICA 110381

ICA 110381

Cat. No. 4950 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 4950 - ICA 110381 | C12H8Cl2N2O | CAS No. 325457-99-6
Description: KV7.2/7.3 activator; displays anticonvulsant properties
Chemical Name: 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

KV7.2/7.3 activator (EC50 = 0.38 μM). Decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures.

Technical Data

M. Wt 267.11
Formula C12H8Cl2N2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 325457-99-6
PubChem ID 4314115
InChI Key FOYOGIUAMYSVIT-UHFFFAOYSA-N
Smiles O=C(NC2=CC=C(Cl)N=C2)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.71 100
ethanol 5.34 20

Preparing Stock Solutions

The following data is based on the product molecular weight 267.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.72 mL 37.44 mL
5 mM 0.75 mL 3.74 mL 7.49 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Amato et al (2011) N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med.Chem.Lett. 2 481

Boehlen et al (2013) The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. Br.J.Pharmacol. 168 1182 PMID: 23176257

If you know of a relevant reference for ICA 110381, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Activators

Keywords: ICA 110381, ICA 110381 supplier, ICA110381, KV7.2/7.3, KV7.2, KV7.3, KV7, KCNQ2, KCNQ3, KCNQ2/3, potassium, channels, epilepsy, seizures, anticonvulsive, antoconvulsant, excitability, neuronal, neurons, Voltage-Gated, Potassium, Channels, 4950, Tocris Bioscience

Citations for ICA 110381

Citations are publications that use Tocris products.

Currently there are no citations for ICA 110381. Do you know of a great paper that uses ICA 110381 from Tocris? Please let us know.

Reviews for ICA 110381

There are currently no reviews for this product. Be the first to review ICA 110381 and earn rewards!

Have you used ICA 110381?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Epilepsy

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.