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Description: KV7.2/7.3 activator; displays anticonvulsant properties
Chemical Name: 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
Purity: ≥98% (HPLC)
Biological Activity
KV7.2/7.3 activator (EC50 = 0.38 μM). Decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures.
Compound Libraries
ICA 110381 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 267.11 |
| Formula | C12H8Cl2N2O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 325457-99-6 |
| PubChem ID | 4314115 |
| InChI Key | FOYOGIUAMYSVIT-UHFFFAOYSA-N |
| Smiles | O=C(NC2=CC=C(Cl)N=C2)C1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.71 | 100 | |
| ethanol | 5.34 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 267.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.74 mL | 18.72 mL | 37.44 mL |
| 5 mM | 0.75 mL | 3.74 mL | 7.49 mL |
| 10 mM | 0.37 mL | 1.87 mL | 3.74 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
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References
References are publications that support the biological activity of the product.
Amato et al (2011) N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med.Chem.Lett. 2 481
Boehlen et al (2013) The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. Br.J.Pharmacol. 168 1182 PMID: 23176257
If you know of a relevant reference for ICA 110381, please let us know.
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Literature in this Area
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