ICA 110381

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Cat.No. 4950 - ICA 110381 | C12H8Cl2N2O | CAS No. 325457-99-6
Description: KV7.2/7.3 activator; displays anticonvulsant properties
Chemical Name: 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

KV7.2/7.3 activator (EC50 = 0.38 μM). Decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures.

Compound Libraries

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Technical Data

M. Wt 267.11
Formula C12H8Cl2N2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 325457-99-6
PubChem ID 4314115
InChI Key FOYOGIUAMYSVIT-UHFFFAOYSA-N
Smiles O=C(NC2=CC=C(Cl)N=C2)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.71 100
ethanol 5.34 20

Preparing Stock Solutions

The following data is based on the product molecular weight 267.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.72 mL 37.44 mL
5 mM 0.75 mL 3.74 mL 7.49 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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References

References are publications that support the biological activity of the product.

Amato et al (2011) N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med.Chem.Lett. 2 481

Boehlen et al (2013) The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. Br.J.Pharmacol. 168 1182 PMID: 23176257


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Citations for ICA 110381

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Literature in this Area

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