ICA 110381

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Description: KV7.2/7.3 activator; displays anticonvulsant properties
Chemical Name: 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
Purity: ≥98% (HPLC)

Biological Activity for ICA 110381

ICA 110381 is a KV7.2/7.3 activator (EC50 = 0.38 μM). Decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures.

Compound Libraries for ICA 110381

ICA 110381 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ICA 110381

M. Wt 267.11
Formula C12H8Cl2N2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 325457-99-6
PubChem ID 4314115
Smiles O=C(NC2=CC=C(Cl)N=C2)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ICA 110381

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.71 100
ethanol 5.34 20

Preparing Stock Solutions for ICA 110381

The following data is based on the product molecular weight 267.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.72 mL 37.44 mL
5 mM 0.75 mL 3.74 mL 7.49 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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References for ICA 110381

References are publications that support the biological activity of the product.

Amato et al (2011) N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med.Chem.Lett. 2 481

Boehlen et al (2013) The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. Br.J.Pharmacol. 168 1182 PMID: 23176257

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Citations for ICA 110381

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