Dofetilide

Pricing Availability Delivery Time Qty
Cat.No. 3757 - Dofetilide | C19H27N3O5S2 | CAS No. 115256-11-6
Description: KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
Alternative Names: Tikosyn, UK 68798
Chemical Name: 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective potassium channel blocker. Blocks KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Displays class III antiarrhythmic properties.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Dofetilide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 441.56
Formula C19H27N3O5S2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 115256-11-6
PubChem ID 71329
InChI Key IXTMWRCNAAVVAI-UHFFFAOYSA-N
Smiles CN(CCC2=CC=C(NS(=O)(C)=O)C=C2)CCOC1=CC=C(NS(=O)(C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 441.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.32 mL 22.65 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gwilt et al (1991) UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. J.Pharmacol.Exp.Ther. 256 318 PMID: 1988662

Carmeliet (1992) Voltage- and time-dependent block of delayed K+ current in cardiac myocytes by dofetilide. J.Pharmacol.Exp.Ther. 262 809 PMID: 1501123

Finlayson et al (2001) [3H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel. Eur.J.Pharmacol. 412 203 PMID: 11166283


If you know of a relevant reference for Dofetilide, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Blockers

Keywords: UK68798 hERG K+ potassium channels blockers inhibits IKR delayed rectifier currents Kv voltage-gated voltage-dependent Human Ether-A-Go-Go Gene Pfizer KV11.1 Tikosyn UK 68798 Voltage-Gated Potassium Channels

1 Citation for Dofetilide

Citations are publications that use Tocris products. Selected citations for Dofetilide include:

Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol 79 42 PMID: 20926757


Do you know of a great paper that uses Dofetilide from Tocris? If so please let us know.

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