JNJ 303

Pricing Availability   Qty
Description: Potent and selective IKs blocker
Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[,7]dec-2-yl]-propanamide
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for JNJ 303

JNJ 303 is a potent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).

Licensing Information

Sold with the permission of Janssen Pharmaceutica NV

Technical Data for JNJ 303

M. Wt 440.98
Formula C21H29ClN2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 878489-28-2
PubChem ID 73016713
Smiles O=C(C(C)(C)OC4=CC=C(Cl)C=C4)NC2C1CC(CC2C3)CC3(NS(=O)(C)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JNJ 303

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.02 25

Preparing Stock Solutions for JNJ 303

The following data is based on the product molecular weight 440.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.07 mL 45.35 mL 90.71 mL
1.25 mM 1.81 mL 9.07 mL 18.14 mL
2.5 mM 0.91 mL 4.54 mL 9.07 mL
12.5 mM 0.18 mL 0.91 mL 1.81 mL

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Product Datasheets for JNJ 303

Certificate of Analysis / Product Datasheet
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References for JNJ 303

References are publications that support the biological activity of the product.

Towart et al (2009) Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening? J.Pharm.Toxicol.Meth 60 1

If you know of a relevant reference for JNJ 303, please let us know.

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Keywords: JNJ 303, JNJ 303 supplier, potent, Iks, blockers, JNJ303, potassium, K+, channels, selective, slow, delayed, rectifier, current, KCNQ1, Kv7.1, voltage-gated, voltage-dependent, Voltage-Gated, Potassium, Channels, 3899, Tocris Bioscience

2 Citations for JNJ 303

Citations are publications that use Tocris products. Selected citations for JNJ 303 include:

Jens et al (2020) Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation. Elife 9 PMID: 33095155

Björk et al (2017) Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes. Front Physiol 8 884 PMID: 29163220

Do you know of a great paper that uses JNJ 303 from Tocris? Please let us know.

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