JNJ 303

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Cat.No. 3899 - JNJ 303 | C21H29ClN2O4S | CAS No. 878489-28-2
Description: Potent and selective IKs blocker
Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).

Licensing Information

Sold with the permission of Janssen Pharmaceutica NV

Technical Data

M. Wt 440.98
Formula C21H29ClN2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 878489-28-2
PubChem ID 73016713
InChI Key OSGIRCJRKSAODN-UHFFFAOYSA-N
Smiles O=C(C(C)(C)OC4=CC=C(Cl)C=C4)NC2C1CC(CC2C3)CC3(NS(=O)(C)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.02 25

Preparing Stock Solutions

The following data is based on the product molecular weight 440.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.07 mL 45.35 mL 90.71 mL
1.25 mM 1.81 mL 9.07 mL 18.14 mL
2.5 mM 0.91 mL 4.54 mL 9.07 mL
12.5 mM 0.18 mL 0.91 mL 1.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Towart et al (2009) Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening? J.Pharm.Toxicol.Meth 60 1


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View all Voltage-gated Potassium (KV) Channel Blockers

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Citations for JNJ 303

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