Inward Rectifier Potassium (Kir) Channels

The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.

Products
Background
Literature (3)
Gene Data

Activators

Cat. No. Product Name / Activity
1377 Cromakalim
Kir6 (KATP) channel opener
0964 Diazoxide
Kir6 (KATP) channel opener
1378 Levcromakalim
Kir6 (KATP) channel opener; active enantiomer of cromakalim (Cat. No. 1377)
0583 Minoxidil
Kir6 channel (KATP) opener
5380 ML 297
Selective Kir3.1/3.2 (GIRK1/2) channel activator
2147 Nicorandil
Kir6 (KATP) channel opener and NO donor
1355 P1075
Potent Kir6 (KATP) channel opener
2580 Tenidap
Opener of Kir2.3. Also cyclooxygenase (COX-1) inhibitor
2076 Y-26763
Kir6 (KATP) channel opener
2077 Y-27152
Prodrug of Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076); orally active in vivo
0882 ZM 226600
Kir6 (KATP) channel opener

Blockers

Cat. No. Product Name / Activity
6086 AMP PNP
Kir6 blocker; non-hydrolyzable AMP analog
3590 Gambogic acid
Kir2.1 channel blocker. Also apoptosis inducer
0911 Glibenclamide
Kir6 (KATP) channel blocker
2396 Glimepiride
Kir6 (KATP) channel blocker
4549 ML 133 hydrochloride
Kir2 channel blocker
6889 ML 418
Kir 7.1 inhibitor; also inhibits Kir 6.2
4231 Nateglinide
Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2 channels
2095 PNU 37883 hydrochloride
Vascular Kir6 (KATP) channel blocker
3805 Repaglinide
Kir6 (KATP) channel blocker
0925 SCH 23390 hydrochloride
Kir3 channel blocker; also potent dopamine D1-like antagonist and 5-HT2C agonist
3948 Terfenadine
KV11.1 (hERG) and Kir6 (KATP) channel blocker. Also H1 antagonist
4339 Tertiapin LQ
Selective Kir1.1 blocker; derivative of tertiapin-Q (Cat. No. 1316)
1316 Tertiapin-Q
Selective blocker of inward-rectifier K+ channels
6877 VU 0134992
Kir4.1 blocker
3891 VU 590 dihydrochloride
Inhibitor of Kir1.1 (ROMK) and Kir7.1
4197 VU 591 hydrochloride
Selective Kir1.1 (ROMK) inhibitor

The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors (SUR).

Structurally, the pore-forming subunit of Kir channels is the α-subunit. It contains a single pore domain between two membrane spanning regions. Four α-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. Kir3.2 with Kir3.3.

External sources of pharmacological information for Inward Rectifier Potassium (Kir) Channels :

    Literature for Inward Rectifier Potassium (Kir) Channels

    Tocris offers the following scientific literature for Inward Rectifier Potassium (Kir) Channels to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


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    Inward-Rectifier Potassium Channel Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    KIR1.1 (ROMK1) (ATP-sensitive) Human KCNJ1 NM_000220 P48048
    Mouse Kcnj1 NM_019659 O88335
    Rat Kcnj1 NM_017023 P35560
    KIR2.1 (IRK1) Human KCNJ2 NM_000891 P63252
    Mouse Kcnj2 NM_008425 P35561
    Rat Kcnj2 NM_017296 Q64273
    KIR2.2(IRK2) Human KCNJ12 NM_021012 Q14500
    Mouse Kcnj12 NM_010603 P52187
    Rat Kcnj12 NM_053981 P52188
    KIR2.3 (IRK3) Human KCNJ4 NM_004981 P48050
    Mouse Kcnj4 NM_008427 P52189
    Rat Kcnj4 NM_053870 P52190
    KIR2.4 (IRK4) Human KCNJ14 NM_013348 Q9UNX9
    Mouse Kcnj14 NM_145963 Q8JZN3
    Rat Kcnj14 NM_170718 O70596
    KIR3.1 (GIRK1) Human KCNJ3 NM_002239 P48549
    Mouse Kcnj3 NM_008426 P63250
    Rat Kcnj3 NM_031610 P63251
    KIR3.2 (GIRK2) Human KCNJ6 NM_002240 P48051
    Mouse Kcnj6 NM_001025590 P48542
    Rat Kcnj6 NM_013192 P48550
    KIR3.3 (GIRK3) Human KCNJ9 NM_004983 Q92806
    Mouse Kcnj9 NM_008429 P48543
    Rat Kcnj9 NM_053834 Q63511
    KIR3.4 (GIRK4) Human KCNJ5 NM_000890 P48544
    Mouse Kcnj5 NM_010605 P48545
    Rat Kcnj5 NM_017297 P48548
    KIR4.1 (KIR1.2) Human KCNJ10 NM_002241 P78508
    Mouse Kcnj10 NM_001039484 Q9JM63
    Rat Kcnj10 NM_031602 P49655
    KIR4.2 (KIR1.3) Human KCNJ15 NM_002243 Q99712
    Mouse Kcnj15 NM_019664 O88932
    Rat Kcnj15 NM_133321 Q91ZF1
    KIR5.1 Human KCNJ16 NM_018658 Q9NPI9
    Mouse Kcnj16 NM_010604 Q9Z307
    Rat Kcnj16 NM_053314 P52191
    KIR6.1 (KATP) Human KCNJ8 NM_004982 Q15842
    Mouse Kcnj8 NM_008428 P97794
    Rat Kcnj8 NM_017099 Q63664
    KIR6.2 (KATP) Human KCNJ11 NM_000525 Q14654
    Mouse Kcnj11 NM_010602 Q61743
    Rat Kcnj11 NM_031358 P70673
    KIR7.1 Human KCNJ13 NM_002242 O60928
    Mouse Kcnj13 NM_008428 P97794
    Rat Kcnj13 NM_053608 O70617