The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.
Inward Rectifier Potassium (Kir) Channel Activators |
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Cat. No. | Product Name / Activity |
0964 | Diazoxide |
Kir6 (KATP) channel opener | |
1378 | Levcromakalim |
Kir6 (KATP) channel opener; active enantiomer of Cromakalim | |
0583 | Minoxidil |
Kir6 channel (KATP) opener | |
5380 | ML 297 |
Selective Kir3.1/3.2 (GIRK1/2) channel activator | |
2580 | Tenidap |
Opener of Kir2.3. Also cyclooxygenase (COX-1) inhibitor | |
7057 | VU 0071063 |
Selective activator of SUR1 Kir6.2 channels | |
2076 | Y-26763 |
Kir6 (KATP) channel opener | |
Inward Rectifier Potassium (Kir) Channel Blockers |
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Cat. No. | Product Name / Activity |
6086 | AMP PNP |
Kir6 blocker; non-hydrolyzable AMP analog | |
1513 | CGP 7930 |
Blocks G protein-coupled inwardly rectifying K+ (GIRK) channels | |
0911 | Glibenclamide |
Kir6 (KATP) channel blocker | |
4549 | ML 133 hydrochloride |
Kir2 channel blocker | |
6889 | ML 418 |
Kir 7.1 inhibitor; also inhibits Kir 6.2 | |
4231 | Nateglinide |
Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2 channels | |
2095 | PNU 37883 hydrochloride |
Vascular Kir6 (KATP) channel blocker | |
3805 | Repaglinide |
Kir6 (KATP) channel blocker | |
0925 | SCH 23390 hydrochloride |
Kir3 channel blocker; also potent dopamine D1-like antagonist and 5-HT2C agonist | |
3948 | Terfenadine |
KV11.1 (hERG) and Kir6 (KATP) channel blocker. Also H1 antagonist | |
1316 | Tertiapin-Q |
Selective blocker of inward-rectifier K+ channels | |
6877 | VU 0134992 |
Kir4.1 blocker |
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors (SUR).
Structurally, the pore-forming subunit of Kir channels is the α-subunit. It contains a single pore domain between two membrane spanning regions. Four α-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. Kir3.2 with Kir3.3.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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KIR1.1 (ROMK1) (ATP-sensitive) | Human | KCNJ1 | NM_000220 | P48048 |
Mouse | Kcnj1 | NM_019659 | O88335 | |
Rat | Kcnj1 | NM_017023 | P35560 | |
KIR2.1 (IRK1) | Human | KCNJ2 | NM_000891 | P63252 |
Mouse | Kcnj2 | NM_008425 | P35561 | |
Rat | Kcnj2 | NM_017296 | Q64273 | |
KIR2.2(IRK2) | Human | KCNJ12 | NM_021012 | Q14500 |
Mouse | Kcnj12 | NM_010603 | P52187 | |
Rat | Kcnj12 | NM_053981 | P52188 | |
KIR2.3 (IRK3) | Human | KCNJ4 | NM_004981 | P48050 |
Mouse | Kcnj4 | NM_008427 | P52189 | |
Rat | Kcnj4 | NM_053870 | P52190 | |
KIR2.4 (IRK4) | Human | KCNJ14 | NM_013348 | Q9UNX9 |
Mouse | Kcnj14 | NM_145963 | Q8JZN3 | |
Rat | Kcnj14 | NM_170718 | O70596 | |
KIR3.1 (GIRK1) | Human | KCNJ3 | NM_002239 | P48549 |
Mouse | Kcnj3 | NM_008426 | P63250 | |
Rat | Kcnj3 | NM_031610 | P63251 | |
KIR3.2 (GIRK2) | Human | KCNJ6 | NM_002240 | P48051 |
Mouse | Kcnj6 | NM_001025590 | P48542 | |
Rat | Kcnj6 | NM_013192 | P48550 | |
KIR3.3 (GIRK3) | Human | KCNJ9 | NM_004983 | Q92806 |
Mouse | Kcnj9 | NM_008429 | P48543 | |
Rat | Kcnj9 | NM_053834 | Q63511 | |
KIR3.4 (GIRK4) | Human | KCNJ5 | NM_000890 | P48544 |
Mouse | Kcnj5 | NM_010605 | P48545 | |
Rat | Kcnj5 | NM_017297 | P48548 | |
KIR4.1 (KIR1.2) | Human | KCNJ10 | NM_002241 | P78508 |
Mouse | Kcnj10 | NM_001039484 | Q9JM63 | |
Rat | Kcnj10 | NM_031602 | P49655 | |
KIR4.2 (KIR1.3) | Human | KCNJ15 | NM_002243 | Q99712 |
Mouse | Kcnj15 | NM_019664 | O88932 | |
Rat | Kcnj15 | NM_133321 | Q91ZF1 | |
KIR5.1 | Human | KCNJ16 | NM_018658 | Q9NPI9 |
Mouse | Kcnj16 | NM_010604 | Q9Z307 | |
Rat | Kcnj16 | NM_053314 | P52191 | |
KIR6.1 (KATP) | Human | KCNJ8 | NM_004982 | Q15842 |
Mouse | Kcnj8 | NM_008428 | P97794 | |
Rat | Kcnj8 | NM_017099 | Q63664 | |
KIR6.2 (KATP) | Human | KCNJ11 | NM_000525 | Q14654 |
Mouse | Kcnj11 | NM_010602 | Q61743 | |
Rat | Kcnj11 | NM_031358 | P70673 | |
KIR7.1 | Human | KCNJ13 | NM_002242 | O60928 |
Mouse | Kcnj13 | NM_008428 | P97794 | |
Rat | Kcnj13 | NM_053608 | O70617 |