Chromanol 293B

Pricing Availability   Qty
Cat.No. 1412 - Chromanol 293B | C15H20N2O4S | CAS No. 163163-23-3
Description: IKs blocker. Also blocks ICFTR
Chemical Name: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews (1)
Literature (5)

Biological Activity

Blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM).

Enantiomer also available.

Technical Data

M. Wt 324.39
Formula C15H20N2O4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 163163-23-3
PubChem ID 121846
InChI Key HVSJHHXUORMCGK-UONOGXRCSA-N
Smiles O[C@H]1[C@H](N(C)S(=O)(CC)=O)C2=C(C=CC(C#N)=C2)OC(C)1C.O[C@@H]3[C@@H](N(C)S(=O)(CC)=O)C4=C(C=CC(C#N)=C4)OC(C)3C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 6.49 20
DMSO 32.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 324.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References

References are publications that support the biological activity of the product.

Bachmann et al (2001) Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKS), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch.Pharmacol. 363 590 PMID: 11414653

Fujisawa et al (2000) Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br.J.Pharmacol. 129 1007 PMID: 10696102

Sun et al (2001) Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J.Cardiovasc.Electrophysiol. 12 472 PMID: 11332571


If you know of a relevant reference for Chromanol 293B, please let us know.

View Related Products by Product Action

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Keywords: Chromanol 293B, Chromanol 293B supplier, IKs, blockers, blocks, ICFTR, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, Cl-, chloride, Chromanol293B, Voltage-Gated, CFTR, 1412, Tocris Bioscience

5 Citations for Chromanol 293B

Citations are publications that use Tocris products. Selected citations for Chromanol 293B include:

Gage and Kobertz (2004) KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels. J Gen Physiol 124 759 PMID: 15572349

Inagaki et al (2019) Involvement of butyrate in electrogenic K+ secretion in rat rectal colon. Pflugers Arch 471 313 PMID: 30250967

Neal et al (2011) Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule. J Physiol 589 3595 PMID: 21576273

Yu et al (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Cell Mol Med 9 e96691 PMID: 24798465

McCallum et al (2011) The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. Mol Pain 15 577 PMID: 20132415


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Reviews for Chromanol 293B

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Chromanol 293B was used to assess how it regulates the gating kinetics of Kv2.1.
By Anonymous on 11/29/2018
Assay Type: In Vitro
Species: Human

Chromanol 293B was used to assess how it regulates the gating kinetics of Kv2.1. The blocking action exhibited by the product was measured on epithelial Kv2.1 channels.

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