Chromanol 293B

Pricing Availability Delivery Time Qty
Cat.No. 1412 - Chromanol 293B | C15H20N2O4S | CAS No. 163163-23-3
Description: IKs blocker. Also blocks ICFTR
Chemical Name: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM). (-)-[3R,4S]-Chromanol 293B (Cat. No. 1475) also available.

Technical Data

M. Wt 324.39
Formula C15H20N2O4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 163163-23-3
PubChem ID 6483057
InChI Key CUJUUWXZAQHCNC-DOFZRALJSA-N
Smiles O[C@H]1[C@H](N(C)S(=O)(CC)=O)C2=C(C=CC(C#N)=C2)OC(C)1C.O[C@@H]3[C@@H](N(C)S(=O)(CC)=O)C4=C(C=CC(C#N)=C4)OC(C)3C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.44 100
ethanol 6.49 20

Preparing Stock Solutions

The following data is based on the product molecular weight 324.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bachmann et al (2001) Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKS), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch.Pharmacol. 363 590 PMID: 11414653

Fujisawa et al (2000) Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br.J.Pharmacol. 129 1007 PMID: 10696102

Sun et al (2001) Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J.Cardiovasc.Electrophysiol. 12 472 PMID: 11332571


If you know of a relevant reference for Chromanol 293B, please let us know.

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Keywords: Chromanol 293B, supplier, IKs, blockers, blocks, ICFTR, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, Cl-, chloride, Chromanol293B, Voltage-Gated, Potassium, Channels, Tocris Bioscience

2 Citations for Chromanol 293B

Citations are publications that use Tocris products. Selected citations for Chromanol 293B include:

McCallum et al (2011) The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. Mol Pain 15 577 PMID: 20132415

Yu et al (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Cell Mol Med 9 e96691 PMID: 24798465


Do you know of a great paper that uses Chromanol 293B from Tocris? If so please let us know.

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