MaxiPost

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Description: Potassium channel modulator; exerts subtype-specific effects
Chemical Name: (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)

Biological Activity for MaxiPost

MaxiPost is a potassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 μM) and GABAA receptors. Displays anxiolytic activity in vivo.

Compound Libraries for MaxiPost

MaxiPost is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MaxiPost

M. Wt 359.7
Formula C16H10ClF4NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 187523-35-9
PubChem ID 214350
InChI Key ULYONBAOIMCNEH-HNNXBMFYSA-N
Smiles O=C2[C@]([C@]3=CC(Cl)=CC=C3OC)(F)C1=CC=C(C(F)(F)F)C=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MaxiPost

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.97 100
ethanol 35.97 100

Preparing Stock Solutions for MaxiPost

The following data is based on the product molecular weight 359.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.9 mL 27.8 mL
5 mM 0.56 mL 2.78 mL 5.56 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for MaxiPost

Certificate of Analysis / Product Datasheet
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References for MaxiPost

References are publications that support the biological activity of the product.

Korsgaard et al (2005) Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J.Pharmacol.Exp.Ther. 314 282 PMID: 15814569

Jepps et al (2012) One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders. Br.J.Pharmacol. 168 19 PMID: 22880633

Hamashima et al (2005) Catalytic enantioselective fluorination of oxindoles. J.Am.Chem.Soc. 127 10164 PMID: 16028916


If you know of a relevant reference for MaxiPost, please let us know.

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Keywords: MaxiPost, MaxiPost supplier, potassium, channels, neuronal, Kv7, calcium, activated, K+, BK, GABAA, receptors, R-enantiomer, anxiolytic, anxiety, anxiolytics, Kv7.1, Voltage-Gated, Potassium, Channels, Ca2+-Activated, Receptors, 4949, Tocris Bioscience

Citations for MaxiPost

Citations are publications that use Tocris products.

Currently there are no citations for MaxiPost. Do you know of a great paper that uses MaxiPost from Tocris? Please let us know.

Reviews for MaxiPost

Average Rating: 5 (Based on 1 Review.)

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MaxiPost was used to study BK channel activation on HEK 293 cell line.
By Anonymous on 12/04/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK 293

MaxiPost(BMS-204352) was used to study BK channel activation on HEK 293 cell line.

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