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Description: Potassium channel modulator; exerts subtype-specific effects
Chemical Name: (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
Purity: ≥98% (HPLC)
Biological Activity for MaxiPost
MaxiPost is a potassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 μM) and GABAA receptors. Displays anxiolytic activity in vivo.
Compound Libraries for MaxiPost
MaxiPost is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for MaxiPost
| M. Wt | 359.7 |
| Formula | C16H10ClF4NO2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 187523-35-9 |
| PubChem ID | 214350 |
| InChI Key | ULYONBAOIMCNEH-HNNXBMFYSA-N |
| Smiles | O=C2[C@]([C@]3=CC(Cl)=CC=C3OC)(F)C1=CC=C(C(F)(F)F)C=C1N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MaxiPost
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.97 | 100 | |
| ethanol | 35.97 | 100 |
Preparing Stock Solutions for MaxiPost
The following data is based on the product molecular weight 359.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.78 mL | 13.9 mL | 27.8 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets for MaxiPost
References for MaxiPost
References are publications that support the biological activity of the product.
Korsgaard et al (2005) Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J.Pharmacol.Exp.Ther. 314 282 PMID: 15814569
Jepps et al (2012) One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders. Br.J.Pharmacol. 168 19 PMID: 22880633
Hamashima et al (2005) Catalytic enantioselective fluorination of oxindoles. J.Am.Chem.Soc. 127 10164 PMID: 16028916
If you know of a relevant reference for MaxiPost, please let us know.
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Keywords: MaxiPost, MaxiPost supplier, potassium, channels, neuronal, Kv7, calcium, activated, K+, BK, GABAA, receptors, R-enantiomer, anxiolytic, anxiety, anxiolytics, Kv7.1, Voltage-Gated, Potassium, Channels, Ca2+-Activated, Receptors, 4949, Tocris Bioscience
Citations for MaxiPost
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Currently there are no citations for MaxiPost. Do you know of a great paper that uses MaxiPost from Tocris? Please let us know.
Reviews for MaxiPost
Average Rating: 5 (Based on 1 Review.)
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MaxiPost was used to study BK channel activation on HEK 293 cell line.
By
Anonymous on 12/04/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK 293
MaxiPost(BMS-204352) was used to study BK channel activation on HEK 293 cell line.
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