Pricing Availability Delivery Time Qty
Cat.No. 4949 - MaxiPost | C16H10ClF4NO2 | CAS No. 187523-35-9
Description: Potassium channel modulator; exerts subtype-specific effects
Chemical Name: (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
Purity: ≥98% (HPLC)

Biological Activity

Potassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 μM) and GABAA receptors. Displays anxiolytic activity in vivo.

Compound Libraries

MaxiPost is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 359.7
Formula C16H10ClF4NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 187523-35-9
PubChem ID 214350
Smiles O=C2[C@]([C@]3=CC(Cl)=CC=C3OC)(F)C1=CC=C(C(F)(F)F)C=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.97 100
ethanol 35.97 100

Preparing Stock Solutions

The following data is based on the product molecular weight 359.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.9 mL 27.8 mL
5 mM 0.56 mL 2.78 mL 5.56 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the biological activity of the product.

Korsgaard et al (2005) Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J.Pharmacol.Exp.Ther. 314 282 PMID: 15814569

Jepps et al (2012) One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders. Br.J.Pharmacol. 168 19 PMID: 22880633

Hamashima et al (2005) Catalytic enantioselective fluorination of oxindoles. J.Am.Chem.Soc. 127 10164 PMID: 16028916

If you know of a relevant reference for MaxiPost, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Modulators

Keywords: MaxiPost, MaxiPost supplier, potassium, channels, neuronal, Kv7, calcium, activated, K+, BK, GABAA, receptors, R-enantiomer, anxiolytic, anxiety, anxiolytics, Kv7.1, Voltage-Gated, Potassium, Channels, Ca2+-Activated, Receptors, 4949, Tocris Bioscience

Citations for MaxiPost

Citations are publications that use Tocris products.

Currently there are no citations for MaxiPost. Do you know of a great paper that uses MaxiPost from Tocris? Please let us know.

Reviews for MaxiPost

There are currently no reviews for this product. Be the first to review MaxiPost and earn rewards!

Have you used MaxiPost?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.