Potassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 μM) and GABAA receptors. Displays anxiolytic activity in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 359.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.78 mL||13.9 mL||27.8 mL|
|5 mM||0.56 mL||2.78 mL||5.56 mL|
|10 mM||0.28 mL||1.39 mL||2.78 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Korsgaard et al (2005) Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J.Pharmacol.Exp.Ther. 314 282 PMID: 15814569
Jepps et al (2012) One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders. Br.J.Pharmacol. 168 19 PMID: 22880633
Hamashima et al (2005) Catalytic enantioselective fluorination of oxindoles. J.Am.Chem.Soc. 127 10164 PMID: 16028916
If you know of a relevant reference for MaxiPost, please let us know.
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Keywords: MaxiPost, supplier, potassium, channels, neuronal, Kv7, calcium, activated, K+, BK, GABAA, receptors, R-enantiomer, anxiolytic, anxiety, anxiolytics, Kv7.1, Voltage-Gated, Potassium, Channels, Tocris Bioscience
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.