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Cat.No. 6233 - Retigabine | C16H18FN3O2 | CAS No. 150812-12-7
Description: KV7 channel activator
Alternative Names: Ezogabine
Chemical Name: Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.

Technical Data

M. Wt 303.33
Formula C16H18FN3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 150812-12-7
PubChem ID 121892
Smiles CCOC(NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.33 100
ethanol 30.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 303.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.3 mL 16.48 mL 32.97 mL
5 mM 0.66 mL 3.3 mL 6.59 mL
10 mM 0.33 mL 1.65 mL 3.3 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet


References are publications that support the biological activity of the product.

Blackburn-Munro et al (2005) Retigabine: chemical synthesis to clinical application. CNS Drug Rev. 11 1 PMID: 15867950

If you know of a relevant reference for Retigabine, please let us know.

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1 Citation for Retigabine

Citations are publications that use Tocris products. Selected citations for Retigabine include:

Afeli et al (2013) Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle. PLoS One 8 e75875 PMID: 24073284

Do you know of a great paper that uses Retigabine from Tocris? Please let us know.

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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.