Retigabine

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Description: KV7 channel activator
Alternative Names: Ezogabine
Chemical Name: Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews (1)

Biological Activity for Retigabine

Retigabine is a KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.

Technical Data for Retigabine

M. Wt 303.33
Formula C16H18FN3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 150812-12-7
PubChem ID 121892
InChI Key PCOBBVZJEWWZFR-UHFFFAOYSA-N
Smiles CCOC(NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Retigabine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.33 100
ethanol 30.33 100

Preparing Stock Solutions for Retigabine

The following data is based on the product molecular weight 303.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.3 mL 16.48 mL 32.97 mL
5 mM 0.66 mL 3.3 mL 6.59 mL
10 mM 0.33 mL 1.65 mL 3.3 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

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Reconstitution Calculator

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References for Retigabine

References are publications that support the biological activity of the product.

Blackburn-Munro et al (2005) Retigabine: chemical synthesis to clinical application. CNS Drug Rev. 11 1 PMID: 15867950


If you know of a relevant reference for Retigabine, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Activators

Keywords: Retigabine, Retigabine supplier, potassium, channel, openers, activators, activates, M, current, anticonvulsant, Kv7, KCNQ, orally, bioavailable, Ezogabine, Voltage-Gated, Potassium, Channels, 6233, Tocris Bioscience

1 Citation for Retigabine

Citations are publications that use Tocris products. Selected citations for Retigabine include:

Afeli et al (2013) Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle. PLoS One 8 e75875 PMID: 24073284


Do you know of a great paper that uses Retigabine from Tocris? Please let us know.

Reviews for Retigabine

Average Rating: 5 (Based on 1 Review.)

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Retigabine studied on HEK 293 cell line : Worked ideally on experimental conditions.
By Farzana Islam on 09/02/2018
Species: Human
Cell Line/Tissue: HEK 293

The aim of my study was to determine if Retigabine shows BK channel activation on Human Embryonic Kidney (HEK 293) cells, when compared to the standard BK activation of NS1619, carried out using non-radioactive Rubidium efflux method and analysed by Flame AAS. 100µM,10µM NS1619,1µM NS1619 and 0.1µM Retigabine concentrations have been used for the study and it performed well under experimental conditions. Graphs show Rubidium efflux percentage observed with Retigabine.

For sterile test compound, dissolve Retigabine in sterile DMSO under a hood.

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