Retigabine

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Cat.No. 6233 - Retigabine | C16H18FN3O2 | CAS No. 150812-12-7
Description: KV7 channel activator
Alternative Names: Ezogabine
Chemical Name: Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.

Technical Data

M. Wt 303.33
Formula C16H18FN3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 150812-12-7
PubChem ID 121892
InChI Key PCOBBVZJEWWZFR-UHFFFAOYSA-N
Smiles CCOC(NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.33 100
ethanol 30.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 303.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.3 mL 16.48 mL 32.97 mL
5 mM 0.66 mL 3.3 mL 6.59 mL
10 mM 0.33 mL 1.65 mL 3.3 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Blackburn-Munro et al (2005) Retigabine: chemical synthesis to clinical application. CNS Drug Rev. 11 1 PMID: 15867950


If you know of a relevant reference for Retigabine, please let us know.

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Citations for Retigabine

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Literature in this Area

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