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Biological Activity for Retigabine
Retigabine is a KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.
Technical Data for Retigabine
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Retigabine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Retigabine
The following data is based on the product molecular weight 303.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.3 mL||16.48 mL||32.97 mL|
|5 mM||0.66 mL||3.3 mL||6.59 mL|
|10 mM||0.33 mL||1.65 mL||3.3 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
References for Retigabine
References are publications that support the biological activity of the product.
Blackburn-Munro et al (2005) Retigabine: chemical synthesis to clinical application. CNS Drug Rev. 11 1 PMID: 15867950
If you know of a relevant reference for Retigabine, please let us know.
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1 Citation for Retigabine
Citations are publications that use Tocris products. Selected citations for Retigabine include:
Afeli et al (2013) Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle. PLoS One 8 e75875 PMID: 24073284
Do you know of a great paper that uses Retigabine from Tocris? Please let us know.
Reviews for Retigabine
Average Rating: 5 (Based on 1 Review.)
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The aim of my study was to determine if Retigabine shows BK channel activation on Human Embryonic Kidney (HEK 293) cells, when compared to the standard BK activation of NS1619, carried out using non-radioactive Rubidium efflux method and analysed by Flame AAS. 100µM,10µM NS1619,1µM NS1619 and 0.1µM Retigabine concentrations have been used for the study and it performed well under experimental conditions. Graphs show Rubidium efflux percentage observed with Retigabine.
For sterile test compound, dissolve Retigabine in sterile DMSO under a hood.
Literature in this Area
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