KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 303.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.3 mL||16.48 mL||32.97 mL|
|5 mM||0.66 mL||3.3 mL||6.59 mL|
|10 mM||0.33 mL||1.65 mL||3.3 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
References are publications that support the products' biological activity.
Blackburn-Munro et al (2005) Retigabine: chemical synthesis to clinical application. CNS Drug Rev. 11 1 PMID: 15867950
If you know of a relevant reference for Retigabine, please let us know.
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Citations for Retigabine
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.