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Submit ReviewNS 1643
Description: KV11.1 (hERG) channel activator; antiarrhythmic
Chemical Name: N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
Purity: ≥98% (HPLC)
Biological Activity for NS 1643
NS 1643 is a human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.
Compound Libraries for NS 1643
NS 1643 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NS 1643
| M. Wt | 380.24 |
| Formula | C15H10F6N2O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 448895-37-2 |
| PubChem ID | 10177784 |
| InChI Key | NJFVQMRYJZHGME-UHFFFAOYSA-N |
| Smiles | OC1=C(NC(NC2=C(O)C=CC(C(F)(F)F)=C2)=O)C=C(C(F)(F)F)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NS 1643
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 38.02 | 100 | |
| DMSO | 9.51 | 25 |
Preparing Stock Solutions for NS 1643
The following data is based on the product molecular weight 380.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.15 mL | 26.3 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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References for NS 1643
References are publications that support the biological activity of the product.
Hansen et al (2006) Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol.Pharmacol. 69 266 PMID: 16219910
Casis et al (2006) Mechanism of action of a novel human ether-a-go-ao related gene channel activator. Mol.Pharmacol. 69 658 PMID: 16284303
Elmedyb et al (2007) Activation of ERG2 potassium channel by the diphenylurea NS1643. Neuropharmacology 53 283 PMID: 17610913
If you know of a relevant reference for NS 1643, please let us know.
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Keywords: NS 1643, NS 1643 supplier, hERG, channel, activators, Antiarrhythmic, Potassium, KV, Channels, Human, Ether-A-Go-Go, Gene, voltage-gated, voltage-dependent, K+, NS1643, Voltage-Gated, 3062, Tocris Bioscience
1 Citation for NS 1643
Citations are publications that use Tocris products. Selected citations for NS 1643 include:
Perissinotti et al (2015) Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel. Biophys J 108 1414 PMID: 25809254
Do you know of a great paper that uses NS 1643 from Tocris? Please let us know.
Reviews for NS 1643
Average Rating: 5 (Based on 1 Review.)
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Standard K.v channel opener: Performed well in biological channel activation studies.
By
Sadequl Islam on 10/12/2018
Assay Type: In Vitro
Species: Mouse
NS 1643 was used to understand its potassium channel opening properties. The product performed well under experimental conditions. Dissolving in ethanol is a better option than disssolving in DMSO as opposed to other K.V channel openers.
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