UK 78282 hydrochloride

Pricing Availability   Qty
Description: Blocker of KV1.3 and KV1.4 channels
Chemical Name: 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride
Purity: ≥99% (HPLC)
Reviews (1)

Biological Activity for UK 78282 hydrochloride

UK 78282 hydrochloride is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks KV1.4 expressed in heart and brain.

Technical Data for UK 78282 hydrochloride

M. Wt 466.05
Formula C29H35NO2.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 136647-02-4
PubChem ID 53393337

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UK 78282 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 23.3 50
ethanol 13.98 30

Preparing Stock Solutions for UK 78282 hydrochloride

The following data is based on the product molecular weight 466.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.29 mL 21.46 mL 42.91 mL
2.5 mM 0.86 mL 4.29 mL 8.58 mL
5 mM 0.43 mL 2.15 mL 4.29 mL
25 mM 0.09 mL 0.43 mL 0.86 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for UK 78282 hydrochloride

References for UK 78282 hydrochloride

References are publications that support the biological activity of the product.

Hanson et al (1999) UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br.J.Pharmacol. 126 1707 PMID: 10372812

Chandy et al (2001) Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon 39 1269 PMID: 11384714

Chandy et al (2004) K+ channels as targets for specific immunomodulation. Trends.Pharmacol.Sci. 25 280 PMID: 15120495

If you know of a relevant reference for UK 78282 hydrochloride, please let us know.

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Blockers

Keywords: UK 78282 hydrochloride, UK 78282 hydrochloride supplier, Kv1.3, Kv1.4, blocker, voltage-gated, potassium, K+, channels, UK78282, HCl, inhibits, T-cell, activation, hydrochloride, Voltage-Gated, Potassium, Channels, 3829, Tocris Bioscience

Citations for UK 78282 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for UK 78282 hydrochloride. Do you know of a great paper that uses UK 78282 hydrochloride from Tocris? Please let us know.

Reviews for UK 78282 hydrochloride

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used UK 78282 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Voltage gated Kv channel blocker with amazing research potential.
By Anonymous on 10/15/2018
Assay Type: In Vitro
Species: Human

Voltage gated Kv channel blocking can be assessed under lab conditions with this product. UK 78782 is an excellent compound to get an understanding of channel blocking of different kind of Kv channel. Was dissolved in ethanol and easy to carry out HPLC on.

review image