UK 78282 hydrochloride

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Cat.No. 3829 - UK 78282 hydrochloride | C29H35NO2.HCl | CAS No. 136647-02-4
Description: Blocker of KV1.3 and KV1.4 channels
Chemical Name: 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks KV1.4 expressed in heart and brain.

Technical Data

M. Wt 466.05
Formula C29H35NO2.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 136647-02-4
PubChem ID 53393337
InChI Key ZZSQARULZYQMIG-UHFFFAOYSA-N
Smiles COC(C=C3)=CC=C3CCCN1CCC(COC(C4=CC=CC=C4)C2=CC=CC=C2)CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.3 50
ethanol 13.98 30

Preparing Stock Solutions

The following data is based on the product molecular weight 466.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.29 mL 21.46 mL 42.91 mL
2.5 mM 0.86 mL 4.29 mL 8.58 mL
5 mM 0.43 mL 2.15 mL 4.29 mL
25 mM 0.09 mL 0.43 mL 0.86 mL

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References

References are publications that support the biological activity of the product.

Hanson et al (1999) UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br.J.Pharmacol. 126 1707 PMID: 10372812

Chandy et al (2001) Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon 39 1269 PMID: 11384714

Chandy et al (2004) K+ channels as targets for specific immunomodulation. Trends.Pharmacol.Sci. 25 280 PMID: 15120495


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Citations for UK 78282 hydrochloride

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Reviews for UK 78282 hydrochloride

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Voltage gated Kv channel blocker with amazing research potential.
By Anonymous on 10/15/2018
Assay Type: In Vitro
Species: Human

Voltage gated Kv channel blocking can be assessed under lab conditions with this product. UK 78782 is an excellent compound to get an understanding of channel blocking of different kind of Kv channel. Was dissolved in ethanol and easy to carry out HPLC on.

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