Neural Stem Cells
Neural stem cells (NSCs) are a subtype of progenitor cells in the nervous system that can self-renew and give rise to differentiated progenitor cells. They are capable of generating lineages of neurons and glia cells, including oligodendrocytes and astrocytes.
| Cat. No. | Product Name / Activity |
|---|---|
| 6476 | Compound E |
| Induces neuronal differentiation; γ-secretase inhibitor | |
| 2634 | DAPT |
| γ-secretase inhibitor; induces neuronal differentiation | |
| 5566 | DG 172 dihydrochloride |
| Augments GM-CSF/IL-4-induced differentiation of mature dendritic cells from bone marrow cells; PPARβ/δ inverse agonist | |
| 1141 | Dibutyryl-cAMP, sodium salt |
| Promotes differentiation of hPSCs to dopaminergic neurons; cell-permeable cAMP analog | |
| 0927 | Fluoxetine hydrochloride |
| 5-HT reuptake inhibitor; induces differentiation of neuronal precursors | |
| 1099 | Forskolin |
| Adenylyl cyclase activator; induces neuronal differentiation | |
| 2845 | IBMX |
| PDE inhibitor; facilitates differentiation of neural progenitor cells | |
| 5513 | Isotretinoin |
| Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiation | |
| 4439 | ISX 9 |
| Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation | |
| 4888 | KHS 101 hydrochloride |
| Selective inducer of neuronal differentiation in hippocampal neural progenitors | |
| 6053 | LDN 193189 dihydrochloride |
| Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs | |
| 2864 | Metformin hydrochloride |
| Activator of LKB1/AMPK; enhances neurogenesis | |
| 6668 | ML 184 |
| Promotes NSC proliferation and differentiation; also selective GPR55 agonist | |
| 5186 | Neuropathiazol |
| Selective inducer of neuronal differentiation in hippocampal neural progenitors | |
| 3854 | 1-Oleoyl lysophosphatidic acid sodium salt |
| LPA1 and LPA2 agonist; inhibits differentiation of neural stem cells into neurons | |
| 4076 | P7C3 |
| Neuroprotective compound; enhances neurogenesis in vivo | |
| 3044 | PD 173074 |
| Selective FGFR1 and -3 inhibitor; inhibits proliferation and differentiation of oligodendrocyte progenitors | |
| 6385 | Phenanthroline |
| Enhances hPSC differentiation into cranial placode cells | |
| 0238 | O-Phospho-L-serine |
| Group III mGlu agonist; enhances differentiation of neural progenitor cells | |
| 4366 | SAG |
| Enhances neuronal differentiation of iPSCs into dopaminergic neurons; Smo agonist | |
| 6390 | SAG dihydrochloride |
| Dihydrochloride salt of SAG; Smo receptor agonist | |
| 3300 | SU 5402 |
| Potent FGFR and VEGFR inhibitor; attenuates integrin β4-induced differentiation of neural stem cells | |
| 3877 | TCS 2210 |
| Inducer of neuronal differentiation in MSCs | |
| 6336 | Trazodone hydrochloride |
| Enhances neural differentiation; also 5-HT2A and α1adrenoceptor antagonist; antidepressant and neuroprotectant | |
| 3835 | TWS 119 |
| GSK-3β inhibitor; induces neuronal differentiation in ESCs | |
| 3115 | WHI-P 154 |
| JAK3 kinase inhibitor; also induces differentiation of neural progenitor cells |
Neural stem cells (NSCs) are a subtype of progenitor cells in the nervous system that can self-renew and give rise to differentiated progenitor cells, which generate lineages of neurons and glia cells, including oligodendrocytes and astrocytes.
NSCs are present in embryonic development and in the adult brain. The stem cell niche architecture allows adult NSCs to continuously generate neurons in the brain throughout life. Adult neural stem cells are found in the two adult neurogenic regions, the hippocampus and the subventricular zone (SVZ), as well as in some non-neurogenic regions, such as the spinal cord.
Literature for Neural Stem Cells
Tocris offers the following scientific literature for Neural Stem Cells to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Our Cancer Research Guide highlights over 750 products for cancer research.
Request copyDownload PDF
Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming.
Request copyDownload PDF
Developed in-house, this poster summarizes how small molecules have been used in protocols across the stem cell workflow.
Request copyDownload PDF
Written by Rebecca Quelch and Stefan Przyborski, this poster summarizes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and potential uses.
Request copyDownload PDF