Neural Stem Cells

Neural stem cells (NSCs) are a subtype of progenitor cells in the nervous system that can self-renew and give rise to differentiated progenitor cells. They are capable of generating lineages of neurons and glia cells, including oligodendrocytes and astrocytes.

Products
Background
Literature
Cat No Product Name / Activity
2634 DAPT
γ-secretase inhibitor; induces neuronal differentiation
5566 DG 172 dihydrochloride
Augments GM-CSF/IL-4-induced differentiation of mature dendritic cells from bone marrow cells; PPARβ/δ inverse agonist
1141 Dibutyryl-cAMP, sodium salt
Promotes differentiation of hPSCs to dopaminergic neurons; cell-permeable cAMP analog
0927 Fluoxetine hydrochloride
5-HT reuptake inhibitor; induces differentiation of neuronal precursors
1099 Forskolin
Adenylyl cyclase activator; induces neuronal differentiation
2845 IBMX
PDE inhibitor; facilitates differentiation of neural progenitor cells
5513 Isotretinoin
Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiation
4439 ISX 9
Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation
4888 KHS 101 hydrochloride
Selective inducer of neuronal differentiation in hippocampal neural progenitors
6053 LDN 193189 dihydrochloride
Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs
2864 Metformin hydrochloride
Activator of LKB1/AMPK; enhances neurogenesis
5186 Neuropathiazol
Selective inducer of neuronal differentiation in hippocampal neural progenitors
3854 1-Oleoyl lysophosphatidic acid sodium salt
LPA1 and LPA2 agonist; inhibits differentiation of neural stem cells into neurons
4076 P7C3
Neuroprotective compound; enhances neurogenesis in vivo
3044 PD 173074
Selective FGFR1 and -3 inhibitor; inhibits proliferation and differentiation of oligodendrocyte progenitors
6385 Phenanthroline
Enhances hPSC differentiation into cranial placode cells
0238 O-Phospho-L-serine
Group III mGlu agonist; enhances differentiation of neural progenitor cells
4366 SAG
Enhances neuronal differentiation of iPSCs into dopaminergic neurons; Smo agonist
6390 SAG dihydrochloride
Dihydrochloride salt of SAG; Smo receptor agonist
3300 SU 5402
Potent FGFR and VEGFR inhibitor; attenuates integrin β4-induced differentiation of neural stem cells
3877 TCS 2210
Inducer of neuronal differentiation in MSCs
6336 Trazodone hydrochloride
Enhances neural differentiation; also 5-HT2A and α1adrenoceptor antagonist; antidepressant and neuroprotectant
3835 TWS 119
GSK-3β inhibitor; induces neuronal differentiation in ESCs
3115 WHI-P 154
JAK3 kinase inhibitor; also induces differentiation of neural progenitor cells

Neural stem cells (NSCs) are a subtype of progenitor cells in the nervous system that can self-renew and give rise to differentiated progenitor cells, which generate lineages of neurons and glia cells, including oligodendrocytes and astrocytes.

NSCs are present in embryonic development and in the adult brain. The stem cell niche architecture allows adult NSCs to continuously generate neurons in the brain throughout life. Adult neural stem cells are found in the two adult neurogenic regions, the hippocampus and the subventricular zone (SVZ), as well as in some non-neurogenic regions, such as the spinal cord.

Literature for Neural Stem Cells

Tocris offers the following scientific literature for Neural Stem Cells to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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