Neural Stem Cells
Neural stem cells (NSCs) are a subtype of progenitor cells in the nervous system that can self-renew and give rise to differentiated progenitor cells. They are capable of generating lineages of neurons and glia cells, including oligodendrocytes and astrocytes.
| Cat. No. | Product Name / Activity |
|---|---|
| 2939 | A 83-01 |
| Promotes neural differentiation of hPSCs; selective inhibitor of TGF-βRI, ALK4 and ALK7 | |
| 7163 | Chroman 1 |
| Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis | |
| 6476 | Compound E |
| Induces neuronal differentiation; γ-secretase inhibitor | |
| 2634 | DAPT |
| Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling | |
| 1141 | Dibutyryl-cAMP, sodium salt |
| Promotes differentiation of hPSCs to dopaminergic neurons; cell-permeable cAMP analog | |
| 3093 | Dorsomorphin dihydrochloride |
| Promotes neural differentiation of hPSCs; also BMP type I receptor inhibitor | |
| 0927 | Fluoxetine hydrochloride |
| 5-HT reuptake inhibitor; induces differentiation of neuronal precursors | |
| 1099 | Forskolin |
| Adenylyl cyclase activator; induces neuronal differentiation | |
| 4912 | GsMTx4 |
| Neuroprotective compound; enhances neurogenesis in human neural stem cells | |
| 2845 | IBMX |
| PDE inhibitor; facilitates differentiation of neural progenitor cells | |
| 1196 | IRL-1620 |
| Promotes neural progenitor cell differentiation and maturation; ETB receptor agonist | |
| 4439 | ISX 9 |
| Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation | |
| 4888 | KHS 101 hydrochloride |
| Selective inducer of neuronal differentiation in hippocampal neural progenitors | |
| 6053 | LDN 193189 dihydrochloride |
| Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs | |
| 2864 | Metformin hydrochloride |
| Activator of LKB1/AMPK; enhances neurogenesis | |
| 6668 | ML 184 |
| Promotes NSC proliferation and differentiation; also selective GPR55 agonist | |
| 7874 | N-Acetylcysteine New |
| Stimulate neuron differentiation and neuritogenesis of ESCs; also GSH precursor; antioxidant | |
| 5186 | Neuropathiazol |
| Selective inducer of neuronal differentiation in hippocampal neural progenitors | |
| 3854 | 1-Oleoyl lysophosphatidic acid sodium salt |
| LPA1 and LPA2 agonist; inhibits differentiation of neural stem cells into neurons | |
| 4076 | P7C3 |
| Neuroprotective compound; enhances neurogenesis in vivo | |
| 3044 | PD 173074 |
| Selective FGFR1 and -3 inhibitor; inhibits proliferation and differentiation of oligodendrocyte progenitors | |
| 6385 | Phenanthroline |
| Enhances hPSC differentiation into cranial placode cells | |
| 3534 | PNU 74654 |
| Promotes neural differentiation of hPSCs; inhibits Wnt signaling | |
| 4366 | SAG |
| Enhances neuronal differentiation of iPSCs into dopaminergic neurons; Smo agonist | |
| 6390 | SAG dihydrochloride |
| Dihydrochloride salt of SAG; Smo receptor agonist | |
| 1614 | SB 431542 |
| Promotes neural differentiation of hPSCs; inhibitor of TGF-βRI, ALK4 and ALK7 | |
| 3300 | SU 5402 |
| Potent FGFR and VEGFR inhibitor; attenuates integrin β4-induced differentiation of neural stem cells | |
| 3877 | TCS 2210 |
| Inducer of neuronal differentiation in MSCs | |
| 6336 | Trazodone hydrochloride |
| Enhances neural differentiation; also 5-HT2A and α1adrenoceptor antagonist; antidepressant and neuroprotectant | |
| 7405 | TWS 119 |
| Induces neuronal differentiation in ESCs; potent GSK3 inhibitor | |
| 3115 | WHI-P 154 |
| JAK3 kinase inhibitor; also induces differentiation of neural progenitor cells | |
| 1254 | Y-27632 dihydrochloride |
| Selective ROCK inhibitor; part of cocktail used to induce neurons from fibroblasts |
Neural stem cells (NSCs) are a subtype of progenitor cells in the nervous system that can self-renew and give rise to differentiated progenitor cells, which generate lineages of neurons and glia cells, including oligodendrocytes and astrocytes.
NSCs are present in embryonic development and in the adult brain. The stem cell niche architecture allows adult NSCs to continuously generate neurons in the brain throughout life. Adult neural stem cells are found in the two adult neurogenic regions, the hippocampus and the subventricular zone (SVZ), as well as in some non-neurogenic regions, such as the spinal cord.
Literature for Neural Stem Cells
Tocris offers the following scientific literature for Neural Stem Cells to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's PosterUpdated
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells PosterUpdated
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Our product guide provides background information on Huntington's disease and highlights products that can be used to research neurodegeneration.
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Our guide highlights the use of small molecules in stem cell research and cell therapy and lists relevant products.
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Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming.
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Our Huntington's Disease (HD) poster summarizes the pathophysiology and molecular changes that occur in HD.
Request copyDownload PDFWritten by Anthony H.V. Schapira
Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD.
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Developed in-house, this poster summarizes how small molecules have been used in protocols across the stem cell workflow.
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Written by Rebecca Quelch and Stefan Przyborski, this poster summarizes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and potential uses.
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