BMP and Other Activin Receptors

Activin receptors transduce signals carried by the TGF-β family of ligands. Such ligands include activin and bone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes, including embryogenesis and tissue homeostasis.

Products
Background
Literature
Pathways
Gene Data

Agonists

Cat. No. Product Name / Activity
6881 SB 4
Potent BMP4 agonist

Inhibitors

Cat. No. Product Name / Activity
6712 A 77-01
Potent inhibitor of TGF-βRI
2939 A 83-01
Selective inhibitor of TGF-βRI, ALK4 and ALK7
4126 DMH-1
Selective ALK2 inhibitor
5580 DMH2
Type I BMP receptor inhibitor
3093 Dorsomorphin dihydrochloride
BMP type I receptor (ALK2, ALK3 and ALK6) inhibitor
4986 K 02288
Type 1 BMP receptor inhibitor
6053 LDN 193189 dihydrochloride
Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs
6151 LDN 212854
Potent bone morphogenetic protein type I (ALK) inhibitor
6152 LDN 214117
Potent and selective ALK2 inhibitor
4945 ML 347
Potent and selective ALK1 and ALK2 inhibitor
3263 SB 505124
Selective inhibitor of TGF-βRI, ALK4 and ALK7

Other

Cat. No. Product Name / Activity
5397 A01
Enhances BMP signaling; Smurf1 inhibitor
4490 Alantolactone
Antiproliferative; induces activin/Smad3 signaling
2694 PD 407824
Senzitizes cells to BMP4; potent and selective inhibitor of Chk1 and Wee1

Related Targets

    Activin receptors transduce signals carried by the TGF-β family of ligands. Such ligands include activin and bone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes, including embryogenesis and tissue homeostasis.

    Bone morphogenetic proteins (BMPs) are a group of growth factors belonging to the transforming growth factor-β (TGF-β) superfamily (excluding BMP1). Primarily characterized by their effects on bone and cartilage formation, research has further elucidated a role for BMPs in cell growth and development.

    There are currently 20 known BMP isoforms, which form dimers in order to bind a tetrameric receptor complex composed of type I and type II BMP receptor subunits. ALK2, ALK3 and ALK6 function as BMP type I receptors, the latter of which are structurally similar. Three BMP type II receptors have also been identified: BMPR2, and type II and IIB activin receptors (ACVR2A and ACVR2B). ALK2, ACVR2A and ACVR2B also function as receptors for activins.

    Signal transduction is continued through Smad proteins. Receptor-regulated Smads (R-Smads) are phosphorylated by activation of type I receptors and form heteromeric complexes with Co-Smads. These complexes regulate the transcription of target genes in the nucleus.

    External sources of pharmacological information for BMP and Other Activin Receptors :

      Literature for BMP and Other Activin Receptors

      Tocris offers the following scientific literature for BMP and Other Activin Receptors to showcase our products. We invite you to request* or download your copy today!

      *Please note that Tocris will only send literature to established scientific business / institute addresses.


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      Pathways for BMP and Other Activin Receptors

      TGF-β

      TGF-β Signaling Pathway

      The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.

      TGF-β Receptor Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      ACVR1
      (ALK2)
      Human ACVR1 NM_001105 -
      Rat Acvr1 NM_024486 P80201
      BMPR1A
      (ALK3)
      Human BMPR1A NM_004329 BC028383
      Mouse Bmpr1a NM_009758 P36895
      Rat Bmpr1a NM_0303849 Q78EA7
      ACVR1B
      (ALK4)
      Human ACVR1B NM_020328 -
      Mouse Acvr1b NM_007395 Q61271
      Rat Acvr1b NM_199230 EDL86909
      BMPR1B
      (ALK6)
      Human BMPR1B NM_001203 D89675
      Mouse Bmpr1b NM_007560 P36898
      Rat Bmpr1b NM_001024259 Q569A5
      BMPR2 Human BMPR2 - Z48923
      Mouse Bmpr2 NM_007561 O35607
      Rat Bmpr2 NM_080407 BAB71720
      ACVR2A Human ACVR2A NM_001616 -
      Mouse Acvr2a NM_007396 A2AI38
      Rat Acvr2a NM_113759.1 EDM00469
      ACVR2B Human ACVR2B NM_001106 X77533
      Mouse Acvr2b NM_007397 -
      Rat Acvr2b NM_031554 NP_113742