BMP and Other Activin Receptors

Activin receptors transduce signals carried by the TGF-β family of ligands. Such ligands include activin and bone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes, including embryogenesis and tissue homeostasis.

Products
Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
2939 A 83-01
Selective inhibitor of TGF-βRI, ALK4 and ALK7
4126 DMH-1
Selective ALK2 inhibitor
5580 DMH2
Type I BMP receptor inhibitor
3093 Dorsomorphin dihydrochloride
BMP type I receptor (ALK2, ALK3 and ALK6) inhibitor
4986 K 02288
Type 1 BMP receptor inhibitor
6053 LDN 193189 dihydrochloride
Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs
6151 LDN 212854
Potent bone morphogenetic protein type I (ALK) inhibitor
6152 LDN 214117
Potent and selective ALK2 inhibitor
4945 ML 347
Potent and selective ALK1 and ALK2 inhibitor
3263 SB 505124
Selective inhibitor of TGF-βRI, ALK4 and ALK7

Other

Cat No Product Name / Activity
5397 A01
Enhances BMP signaling; Smurf1 inhibitor
4490 Alantolactone
Antiproliferative; induces activin/Smad3 signaling

Related Targets

    Activin receptors transduce signals carried by the TGF-β family of ligands. Such ligands include activin and bone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes, including embryogenesis and tissue homeostasis.

    Bone morphogenetic proteins (BMPs) are a group of growth factors belonging to the transforming growth factor-β (TGF-β) superfamily (excluding BMP1). Primarily characterized by their effects on bone and cartilage formation, research has further elucidated a role for BMPs in cell growth and development.

    There are currently 20 known BMP isoforms, which form dimers in order to bind a tetrameric receptor complex composed of type I and type II BMP receptor subunits. ALK2, ALK3 and ALK6 function as BMP type I receptors, the latter of which are structurally similar. Three BMP type II receptors have also been identified: BMPR2, and type II and IIB activin receptors (ACVR2A and ACVR2B). ALK2, ACVR2A and ACVR2B also function as receptors for activins.

    Signal transduction is continued through Smad proteins. Receptor-regulated Smads (R-Smads) are phosphorylated by activation of type I receptors and form heteromeric complexes with Co-Smads. These complexes regulate the transcription of target genes in the nucleus.

    Literature for BMP and Other Activin Receptors

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases

    Pathways for BMP and Other Activin Receptors

    TGF-β

    TGF-β Signaling Pathway

    The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.

    TGF-β Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    ACVR1
    (ALK2)
    Human ACVR1 NM_001105 -
    Rat Acvr1 NM_024486 P80201
    BMPR1A
    (ALK3)
    Human BMPR1A NM_004329 BC028383
    Mouse Bmpr1a NM_009758 P36895
    Rat Bmpr1a NM_0303849 Q78EA7
    ACVR1B
    (ALK4)
    Human ACVR1B NM_020328 -
    Mouse Acvr1b NM_007395 Q61271
    Rat Acvr1b NM_199230 EDL86909
    BMPR1B
    (ALK6)
    Human BMPR1B NM_001203 D89675
    Mouse Bmpr1b NM_007560 P36898
    Rat Bmpr1b NM_001024259 Q569A5
    BMPR2 Human BMPR2 - Z48923
    Mouse Bmpr2 NM_007561 O35607
    Rat Bmpr2 NM_080407 BAB71720
    ACVR2A Human ACVR2A NM_001616 -
    Mouse Acvr2a NM_007396 A2AI38
    Rat Acvr2a NM_113759.1 EDM00469
    ACVR2B Human ACVR2B NM_001106 X77533
    Mouse Acvr2b NM_007397 -
    Rat Acvr2b NM_031554 NP_113742