BMP and Other Activin Receptors

Activin receptors transduce signals carried by the TGF-β family of ligands. Such ligands include activin and bone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes, including embryogenesis and tissue homeostasis.

Products
Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
2939 A 83-01
Selective inhibitor of TGF-βRI, ALK4 and ALK7
4126 DMH-1
Selective ALK2 inhibitor
5580 DMH2
Type I BMP receptor inhibitor
3093 Dorsomorphin dihydrochloride
BMP type I receptor (ALK2, ALK3 and ALK6) inhibitor
4986 K 02288
Type 1 BMP receptor inhibitor
6053 LDN 193189 dihydrochloride
Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs
6151 LDN 212854
Potent bone morphogenetic protein type I (ALK) inhibitor
6152 LDN 214117
Potent and selective ALK2 inhibitor
4945 ML 347
Potent and selective ALK1 and ALK2 inhibitor
3263 SB 505124
Selective inhibitor of TGF-βRI, ALK4 and ALK7

Other

Cat No Product Name / Activity
5397 A01
Enhances BMP signaling; Smurf1 inhibitor
4490 Alantolactone
Antiproliferative; induces activin/Smad3 signaling

Related Targets

    Activin receptors transduce signals carried by the TGF-β family of ligands. Such ligands include activin and bone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes, including embryogenesis and tissue homeostasis.

    Bone morphogenetic proteins (BMPs) are a group of growth factors belonging to the transforming growth factor-β (TGF-β) superfamily (excluding BMP1). Primarily characterized by their effects on bone and cartilage formation, research has further elucidated a role for BMPs in cell growth and development.

    There are currently 20 known BMP isoforms, which form dimers in order to bind a tetrameric receptor complex composed of type I and type II BMP receptor subunits. ALK2, ALK3 and ALK6 function as BMP type I receptors, the latter of which are structurally similar. Three BMP type II receptors have also been identified: BMPR2, and type II and IIB activin receptors (ACVR2A and ACVR2B). ALK2, ACVR2A and ACVR2B also function as receptors for activins.

    Signal transduction is continued through Smad proteins. Receptor-regulated Smads (R-Smads) are phosphorylated by activation of type I receptors and form heteromeric complexes with Co-Smads. These complexes regulate the transcription of target genes in the nucleus.

    Literature for BMP and Other Activin Receptors

    Tocris offers the following scientific literature for BMP and Other Activin Receptors to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases

    Pathways for BMP and Other Activin Receptors

    TGF-β

    TGF-β Signaling Pathway

    The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.

    TGF-β Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    ACVR1
    (ALK2)
    Human ACVR1 NM_001105 -
    Rat Acvr1 NM_024486 P80201
    BMPR1A
    (ALK3)
    Human BMPR1A NM_004329 BC028383
    Mouse Bmpr1a NM_009758 P36895
    Rat Bmpr1a NM_0303849 Q78EA7
    ACVR1B
    (ALK4)
    Human ACVR1B NM_020328 -
    Mouse Acvr1b NM_007395 Q61271
    Rat Acvr1b NM_199230 EDL86909
    BMPR1B
    (ALK6)
    Human BMPR1B NM_001203 D89675
    Mouse Bmpr1b NM_007560 P36898
    Rat Bmpr1b NM_001024259 Q569A5
    BMPR2 Human BMPR2 - Z48923
    Mouse Bmpr2 NM_007561 O35607
    Rat Bmpr2 NM_080407 BAB71720
    ACVR2A Human ACVR2A NM_001616 -
    Mouse Acvr2a NM_007396 A2AI38
    Rat Acvr2a NM_113759.1 EDM00469
    ACVR2B Human ACVR2B NM_001106 X77533
    Mouse Acvr2b NM_007397 -
    Rat Acvr2b NM_031554 NP_113742