ML 184

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Cat.No. 6668 - ML 184 | C25H34N4O3S | CAS No. 794572-10-4
Description: Selective GPR55 agonist; also promotes NSC proliferation and differentiation
Alternative Names: CID 20440433
Chemical Name: 3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective GPR55 agonist (EC50 = 250 nM). Exhibits >100-fold selectivity for GPR55 over GPR35, CB1 and CB2. Increases proliferation of neural stem cells and promotes neuronal differentiation in vitro.

Technical Data

M. Wt 470.63
Formula C25H34N4O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 794572-10-4
PubChem ID 2440433
InChI Key VRSJAHQGJHDACS-UHFFFAOYSA-N
Smiles CN(S(=O)(C1=CC(C(N2CCN(C3=C(C(C)=CC=C3)C)CC2)=O)=C(N4CCCC4)C=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.41 20

Preparing Stock Solutions

The following data is based on the product molecular weight 470.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.62 mL 53.12 mL 106.24 mL
1 mM 2.12 mL 10.62 mL 21.25 mL
2 mM 1.06 mL 5.31 mL 10.62 mL
10 mM 0.21 mL 1.06 mL 2.12 mL

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References

References are publications that support the biological activity of the product.

Hill et al (2018) Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br.J.Pharmacol. 175 3407 PMID: 29888782

Kotsikorou et al (2011) Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 50 5633 PMID: 21534610


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