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ML 184 is a selective GPR55 agonist (EC50 = 250 nM). Exhibits >100-fold selectivity for GPR55 over GPR35, CB1 and CB2. Increases proliferation of neural stem cells and promotes neuronal differentiation in vitro.
ML 184 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 470.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.62 mL||53.12 mL||106.24 mL|
|1 mM||2.12 mL||10.62 mL||21.25 mL|
|2 mM||1.06 mL||5.31 mL||10.62 mL|
|10 mM||0.21 mL||1.06 mL||2.12 mL|
References are publications that support the biological activity of the product.
Hill et al (2018) Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br.J.Pharmacol. 175 3407 PMID: 29888782
Kotsikorou et al (2011) Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 50 5633 PMID: 21534610
If you know of a relevant reference for ML 184, please let us know.
Keywords: ML 184, ML 184 supplier, ML184, gpr55, agonists, agonism, selective, neural, stem, cell, proliferation, differentiation, NSC, CID, 20440433, GPR55, Neural, Stem, Cells, 6668, Tocris Bioscience
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