Fluoxetine hydrochloride

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Cat.No. 0927 - Fluoxetine hydrochloride | C17H18F3NO.HCl | CAS No. 56296-78-7
Description: 5-HT reuptake inhibitor
Chemical Name: N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (10)
Reviews (1)
Literature (2)

Biological Activity

Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics.

Licensing Information

Sold with the permission of Eli Lilly and Company

Compound Libraries

Fluoxetine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 345.78
Formula C17H18F3NO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 56296-78-7
PubChem ID 62857
InChI Key GIYXAJPCNFJEHY-UHFFFAOYSA-N
Smiles Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.58 100
water 3.46 10

Preparing Stock Solutions

The following data is based on the product molecular weight 345.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.46 mL 28.92 mL
5 mM 0.58 mL 2.89 mL 5.78 mL
10 mM 0.29 mL 1.45 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Beck et al (1997) Fluoxetine selectively alters 5-hydroxytryptamine1A and γ-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. J.Pharmacol.Exp.Ther. 281 115 PMID: 9103487

Benfield et al (1986) Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness. Drugs 32 481 PMID: 2878798

Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006

Chang et al (2010) Increased cellular turnover in response to fluox. in neuronal precursors derived from human embryonic stem cells. Int.J.Dev.Biol. 54 707 PMID: 19598107


If you know of a relevant reference for Fluoxetine hydrochloride, please let us know.

View Related Products by Product Action

View all 5-HT Transporter Inhibitors

Keywords: Fluoxetine hydrochloride, Fluoxetine hydrochloride supplier, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Neural, Stem, Cells, 0927, Tocris Bioscience

10 Citations for Fluoxetine hydrochloride

Citations are publications that use Tocris products. Selected citations for Fluoxetine hydrochloride include:

Hooper et al (2016) Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol 311 H572 PMID: 27371685

Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126

Kurita et al (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci 15 1245 PMID: 22864611

MacLean et al (2004) Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. J Pharmacol Exp Ther 109 2150 PMID: 15078799


Do you know of a great paper that uses Fluoxetine hydrochloride from Tocris? Please let us know.

Reviews for Fluoxetine hydrochloride

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Fluoxetine decreases cued fear recall in c57bl6J mice.
By Olivia Hon on 05/23/2019
Assay Type: In Vivo
Species: Mouse

10mg/kg fluoxetine hcl injected i.p. in male c57Bl6J mice before cued fear conditioning, significantly decreased freezing during fear recall 24 hours later

given 60 min before behavior, dissolved in.9% sterile saline

review image

Literature in this Area

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