Fluoxetine hydrochloride

Pricing Availability   Qty
Description: 5-HT reuptake inhibitor
Chemical Name: N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
Purity: ≥99% (HPLC)
Citations (10)
Reviews (1)
Literature (1)

Biological Activity for Fluoxetine hydrochloride

Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900-fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Fluoxetine also inhibits assembly and activation of the NLRP3-ASC inflammasome and prevents degeneration of retinal pigmented epithelium (RPE) cells in an animal model of dry age-related macular degeneration (AMD).

Licensing Information

Sold with the permission of Eli Lilly and Company

Compound Libraries for Fluoxetine hydrochloride

Fluoxetine hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Fluoxetine hydrochloride

M. Wt 345.78
Formula C17H18F3NO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 56296-78-7
PubChem ID 62857
Smiles Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Fluoxetine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.58 100
water 3.46 10

Preparing Stock Solutions for Fluoxetine hydrochloride

The following data is based on the product molecular weight 345.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.46 mL 28.92 mL
5 mM 0.58 mL 2.89 mL 5.78 mL
10 mM 0.29 mL 1.45 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Fluoxetine hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for Fluoxetine hydrochloride

References are publications that support the biological activity of the product.

Beck et al (1997) Fluoxetine selectively alters 5-hydroxytryptamine1A and γ-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. J.Pharmacol.Exp.Ther. 281 115 PMID: 9103487

Benfield et al (1986) Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness. Drugs 32 481 PMID: 2878798

Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006

Chang et al (2010) Increased cellular turnover in response to fluox. in neuronal precursors derived from human embryonic stem cells. Int.J.Dev.Biol. 54 707 PMID: 19598107

Ambati et al (2021) Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration. Proc.Natl.Acad.Sci.USA 118 e2102975118 PMID: 34620711

If you know of a relevant reference for Fluoxetine hydrochloride, please let us know.

View Related Products by Product Action

View all 5-HT Transporter Inhibitors

Keywords: Fluoxetine hydrochloride, Fluoxetine hydrochloride supplier, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, NLRP3, inflammasome, Neural, Stem, Cells, Inflammasomes, 0927, Tocris Bioscience

10 Citations for Fluoxetine hydrochloride

Citations are publications that use Tocris products. Selected citations for Fluoxetine hydrochloride include:

Hooper et al (2016) Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol 311 H572 PMID: 27371685

Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126

Zhang and Gaudry (2016) Functional integration of a serotonergic neuron in the Drosophila antennal lobe. Elife 5 PMID: 27572257

Sallin and Jazwinska (2016) Acute stress is detrimental to heart regeneration in zebrafish. Open Biol 6 PMID: 27030176

Do you know of a great paper that uses Fluoxetine hydrochloride from Tocris? Please let us know.

Reviews for Fluoxetine hydrochloride

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used Fluoxetine hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Fluoxetine decreases cued fear recall in c57bl6J mice.
By Olivia Hon on 05/23/2019
Assay Type: In Vivo
Species: Mouse

10mg/kg fluoxetine hcl injected i.p. in male c57Bl6J mice before cued fear conditioning, significantly decreased freezing during fear recall 24 hours later

given 60 min before behavior, dissolved in.9% sterile saline

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.