Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics.
Sold with the permission of Eli Lilly and Company
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 345.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.89 mL||14.46 mL||28.92 mL|
|5 mM||0.58 mL||2.89 mL||5.78 mL|
|10 mM||0.29 mL||1.45 mL||2.89 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References are publications that support the products' biological activity.
Beck et al (1997) Fluoxetine selectively alters 5-hydroxytryptamine1A and γ-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. J.Pharmacol.Exp.Ther. 281 115 PMID: 9103487
Benfield et al (1986) Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness. Drugs 32 481 PMID: 2878798
Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006
Chang et al (2010) Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells. Int.J.Dev.Biol. 54 707 PMID: 19598107
If you know of a relevant reference for Fluoxetine hydrochloride, please let us know.
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Keywords: Fluoxetine hydrochloride, supplier, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 5-HT, Transporters, Neural, Stem, Cells, 5-HT, Transporters, Tocris Bioscience
3 Citations for Fluoxetine hydrochloride
Citations are publications that use Tocris products. Selected citations for Fluoxetine hydrochloride include:
MacLean et al (2004) Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. J Pharmacol Exp Ther 109 2150 PMID: 15078799
Pai et al (2015) Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation. J Neurosci 35 4366 PMID: 25762681
Silva et al (2014) Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion. PLoS One 9 e89641 PMID: 24586928
Do you know of a great paper that uses Fluoxetine hydrochloride from Tocris? If so please let us know.
Fluoxetine hydrochloride Reviews
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Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.