PluriSln 1

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Description: SCD-1 inhibitor
Alternative Names: NSC 14613
Chemical Name: 4-Pyridinecarboxylic acid 2-phenylhydrazide
Purity: ≥99% (HPLC)

Biological Activity for PluriSln 1

PluriSln 1 is a stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice.

Compound Libraries for PluriSln 1

PluriSln 1 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for PluriSln 1

M. Wt 213.24
Formula C12H11N3O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 91396-88-2
PubChem ID 225362
Smiles O=C(NNC2=CC=CC=C2)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PluriSln 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.32 100
ethanol 21.32 100

Preparing Stock Solutions for PluriSln 1

The following data is based on the product molecular weight 213.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.69 mL 23.45 mL 46.9 mL
5 mM 0.94 mL 4.69 mL 9.38 mL
10 mM 0.47 mL 2.34 mL 4.69 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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References for PluriSln 1

References are publications that support the biological activity of the product.

Ben-David et al (2013) Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12 167 PMID: 23318055

If you know of a relevant reference for PluriSln 1, please let us know.

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Citations for PluriSln 1

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