PluriSln 1

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Cat.No. 4847 - PluriSln 1 | C12H11N3O | CAS No. 91396-88-2
Description: SCD-1 inhibitor
Alternative Names: NSC 14613
Chemical Name: 4-Pyridinecarboxylic acid 2-phenylhydrazide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice.

Compound Libraries

PluriSln 1 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 213.24
Formula C12H11N3O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 91396-88-2
PubChem ID 225362
InChI Key HUDWXDLBWRHCKO-UHFFFAOYSA-N
Smiles O=C(NNC2=CC=CC=C2)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.32 100
ethanol 21.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 213.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.69 mL 23.45 mL 46.9 mL
5 mM 0.94 mL 4.69 mL 9.38 mL
10 mM 0.47 mL 2.34 mL 4.69 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ben-David et al (2013) Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12 167 PMID: 23318055


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View all Stearoyl-CoA 9-Desaturase Inhibitors

Keywords: PluriSln1 stearoyl-CoA desaturase SCD1 inhibitors inhibits human pluripotent stem cells hPSCs inhibitors inhibits selective elimination eliminates NSC 14613 Stearoyl-CoA 9-desaturase

Citations for PluriSln 1

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for PluriSln 1

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