Neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 234.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.27 mL||21.34 mL||42.69 mL|
|5 mM||0.85 mL||4.27 mL||8.54 mL|
|10 mM||0.43 mL||2.13 mL||4.27 mL|
|50 mM||0.09 mL||0.43 mL||0.85 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Schneider et al (2008) Small-molecule activation of neuronal cell fate. Nat.Chem.Biol 4 408 PMID: 18552832
Dioum et al (2011) A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proc.Natl.Acad.Sci.U.S.A. 108 20713 PMID: 22143803
Zhang et al (2011) Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Differentiation 81 233 PMID: 21419563
Russell et al (2012) Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem.Biol. 7 1067 PMID: 22413910
If you know of a relevant reference for ISX 9, please let us know.
Keywords: ISX 9, supplier, ISX9, isoxazoles, neurogenic, neuronal, differentiation, neuroD1, CaMKII, MEF2, neurogenesis, Isx1, Neuronal, differentiator, inducer, III, Neural, Stem, Cells, Tocris Bioscience
Citations for ISX 9
Citations are publications that use Tocris products.
Currently there are no citations for ISX 9. Do you know of a great paper that uses ISX 9 from Tocris? If so please let us know.
Literature in this Area
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.