ISX 9

Pricing Availability Delivery Time Qty
Cat.No. 4439 - ISX 9 | C11H10N2O2S | CAS No. 832115-62-5
Description: Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation
Chemical Name: N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Protocols (1)
Literature

Biological Activity

Neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro.

Compound Libraries

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Technical Data

M. Wt 234.27
Formula C11H10N2O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 832115-62-5
PubChem ID 19582717
InChI Key SYENTKHGMVKGAQ-UHFFFAOYSA-N
Smiles O=C(NC2CC2)C1=NOC(C3=CC=CS3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.43 100
ethanol 11.71 50

Preparing Stock Solutions

The following data is based on the product molecular weight 234.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.34 mL 42.69 mL
5 mM 0.85 mL 4.27 mL 8.54 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Schneider et al (2008) Small-molecule activation of neuronal cell fate. Nat.Chem.Biol 4 408 PMID: 18552832

Dioum et al (2011) A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proc.Natl.Acad.Sci.U.S.A. 108 20713 PMID: 22143803

Zhang et al (2011) Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Differentiation 81 233 PMID: 21419563

Russell et al (2012) Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem.Biol. 7 1067 PMID: 22413910


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Keywords: ISX 9, ISX 9 supplier, ISX9, isoxazoles, neurogenic, neuronal, differentiation, neuroD1, CaMKII, MEF2, neurogenesis, Isx1, Neuronal, differentiator, inducer, III, Neural, Stem, Cells, Cardiomyocyte, 4439, Tocris Bioscience

1 Citation for ISX 9

Citations are publications that use Tocris products. Selected citations for ISX 9 include:

Koh et al (2015) Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells. PLoS One 10 e0138724 PMID: 26407349


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Protocols for ISX 9

The following protocol features additional information for the use of ISX 9 (Cat. No. 4439).

Literature in this Area

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