GsMTx4

Pricing Availability   Qty
Cat.No. 4912 - GsMTx4 | Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2
Description: TRPC1 and TRPC6 blocker; inhibits mechanosensitive ion channels
Datasheet
Citations (1)
Reviews (1)
Literature

Biological Activity

TRPC1 and TRPC6 blocker. Also blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.

Licensing Information

Sold under license from The Research Foundation of The State University of New York

Technical Data

M. Wt 4095.86
Formula C185H273N49O45S6
Sequence GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF

(Modifications: Disulfide bridge: 2-17,9-23,16-30)

(Modifications: Phe-34 = C-terminal amide)

Storage Store at -20°C
PubChem ID 90488987
InChI Key WVDNTWXIIKNMHY-UHFFFAOYSA-N
Smiles [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bowman et al (2007) Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon. 49 249 PMID: 17157345

Suchyna et al (2000) Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J.Gen.Physiol. 115 583 PMID: 10779316

Drew et al (2007) High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One 2 e515 PMID: 17565368


If you know of a relevant reference for GsMTx4, please let us know.

View Related Products by Product Action

View all TRPC Blockers

Keywords: GsMTx4, GsMTx4 supplier, TRPC, transient, receptor, potential, TRPC1, and, TRPC6, mechanosensitive, ion, channels, MSCs, blockers, blocks, inhibits, inhibitors, venoms, 4912, Tocris Bioscience

1 Citation for GsMTx4

Citations are publications that use Tocris products. Selected citations for GsMTx4 include:

Dela Paz (2018) Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun 497 220 PMID: 29428723


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Reviews for GsMTx4

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a mechanosensitive channel blocker
By Hyun Choi on 02/19/2018
Assay Type: Ex Vivo
Species: Rat
Cell Line/Tissue: Applied to brain slices

It blocks mechanosensitive channels such as TRPC1 and 6.Dissolved in artificial cerebrospinal fluid (acsf) at 20 microM.


Literature in this Area

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