Dibutyryl-cAMP, sodium salt
Biological Activity
Cell-permeable analog of cAMP; activates cAMP-dependent protein kinases. Promotes differentiation of dopaminergic neurons (iDA) from hPSCs in combination with other reagents.
Compound Libraries
Dibutyryl-cAMP, sodium salt is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 491.37 |
| Formula | C18H23N5NaO8P |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 16980-89-5 |
| PubChem ID | 23663967 |
| InChI Key | KRBZRVBLIUDQNG-JBVYASIDSA-M |
| Smiles | [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](OC(=O)CCC)[C@@H](O2)N1C=NC2=C1N=CN=C2NC(=O)CCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.14 | 100 | |
| water | 49.14 | 100 | |
| phosphate buffered saline | 49.14 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 491.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.04 mL | 10.18 mL | 20.35 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.07 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.04 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Carranza et al (1998) Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 511 235 PMID: 9679177
Hei et al (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs Mol.Pharmacol. 39 233 PMID: 1847496
Imamura et al (1998) Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes. Proc.Natl.Acad.Sci.U.S.A. 95 6139 PMID: 9600931
Xia et al (2016) Transcriptional comparison of human induced and primary midbrain dopaminergic neurons. Sci.Rep. 6 20270 PMID: 26842779
If you know of a relevant reference for Dibutyryl-cAMP, sodium salt, please let us know.
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Keywords: Cell-permeable cAMP Cyclic adenosines Monophosphate Inositol Signaling Signalling cAMP-dependent protein kinase PKA Kinase A differentiation cAMP
1 Citation for Dibutyryl-cAMP, sodium salt
Citations are publications that use Tocris products. Selected citations for Dibutyryl-cAMP, sodium salt include:
Park et al (2005) Activation of inward rectifier K+ channels by hypoxia in rabbit coronary arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 289 H2461 PMID: 16284107
Do you know of a great paper that uses Dibutyryl-cAMP, sodium salt from Tocris? If so please let us know.
