Dibutyryl-cAMP, sodium salt

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Cat.No. 1141 - Dibutyryl-cAMP, sodium salt | C18H23N5NaO8P | CAS No. 16980-89-5
Description: Cell-permeable cAMP analog
Chemical Name: N6,O2'-Dibutyryl adenosine 3',5'-cyclic monophosphate sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Cell-permeable analog of cAMP; activates cAMP-dependent protein kinases. Promotes differentiation of dopaminergic neurons (iDA) from hPSCs in combination with other reagents.

Compound Libraries

Dibutyryl-cAMP, sodium salt is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 491.37
Formula C18H23N5NaO8P
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 16980-89-5
PubChem ID 23663967
InChI Key KRBZRVBLIUDQNG-JBVYASIDSA-M
Smiles [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](OC(=O)CCC)[C@@H](O2)N1C=NC2=C1N=CN=C2NC(=O)CCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 49.14 100
DMSO 49.14 100
water 49.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 491.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.18 mL 20.35 mL
5 mM 0.41 mL 2.04 mL 4.07 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Carranza et al (1998) Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 511 235 PMID: 9679177

Hei et al (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs Mol.Pharmacol. 39 233 PMID: 1847496

Imamura et al (1998) Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes. Proc.Natl.Acad.Sci.U.S.A. 95 6139 PMID: 9600931

Xia et al (2016) Transcriptional comparison of human induced and primary midbrain dopaminergic neurons. Sci.Rep. 6 20270 PMID: 26842779


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Keywords: Dibutyryl-cAMP, sodium salt, supplier, Cell-permeable, cAMP, Cyclic, adenosines, Monophosphate, Inositol, Signaling, Signalling, cAMP-dependent, protein, kinase, PKA, Kinase, A, differentiation, cAMP, ESCs, and, iPSC, Neural, Stem, Cells, cAMP, Tocris Bioscience

1 Citation for Dibutyryl-cAMP, sodium salt

Citations are publications that use Tocris products. Selected citations for Dibutyryl-cAMP, sodium salt include:

Park et al (2005) Activation of inward rectifier K+ channels by hypoxia in rabbit coronary arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 289 H2461 PMID: 16284107


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