You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
1-Oleoyl lysophosphatidic acid sodium salt
1-Oleoyl lysophosphatidic acid sodium salt is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. 1-Oleoyl lysophosphatidic acid sodium salt inhibits differentiation of neural stem cells (NSCs) into neurons.
Note: This product is typically prepared in PBS, pH 7.2, at a concentration of up to approximately 4 mg/mL.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
van Corven et al (1992) Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Biochem.J. 281 163 PMID: 1731751
Dottori et al (2008) Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells. Stem Cells 26 1146 PMID: 18308941
Lapierre et al (2010) Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J.Biol.Chem. 285 25792 PMID: 20551326
If you know of a relevant reference for 1-Oleoyl lysophosphatidic acid sodium salt, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 1-Oleoyl lysophosphatidic acid sodium salt, 1-Oleoyl lysophosphatidic acid sodium salt supplier, lysophosphatidic, acid, LPA, lysophospholipid, receptors, LPL-R, agonists, Lysophosphatidic, Acid, Receptors, Neural, Stem, Cells, 3854, Tocris Bioscience
2 Citations for 1-Oleoyl lysophosphatidic acid sodium salt
Citations are publications that use Tocris products. Selected citations for 1-Oleoyl lysophosphatidic acid sodium salt include:
Ruprecht et al (2015) Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. J Clin Invest 160 673 PMID: 25679761
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Do you know of a great paper that uses 1-Oleoyl lysophosphatidic acid sodium salt from Tocris? Please let us know.
Reviews for 1-Oleoyl lysophosphatidic acid sodium salt
Average Rating: 5 (Based on 3 Reviews.)
Have you used 1-Oleoyl lysophosphatidic acid sodium salt?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
MG-63 cells were pre-incubated with indicated inhibitors for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. All inhibitors prevented COX-2 induction by LPA.
Primary mouse mammary glands were digested, incubated with LPA or control at 5uM and then analyzed using CD24/CD29 to identify effects on the stem cell pool. A 50% reduction in the stem cell pool (p4) was identified after LPA treatment.
MG-63 cells were treated with 10 µM LPA (0-48 h) to follow COX-2 expression using Western blot. LPA induced COX-2 expression in a time-dependent manner in osteosarcoma cells.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.