1-Oleoyl lysophosphatidic acid sodium salt
Endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. Inhibits differentiation of neural stem cells (NSCs) into neurons.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|phosphate buffered saline||4.58||10|
Preparing Stock Solutions
The following data is based on the product molecular weight 458.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.18 mL||10.91 mL||21.81 mL|
|5 mM||0.44 mL||2.18 mL||4.36 mL|
|10 mM||0.22 mL||1.09 mL||2.18 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the biological activity of the product.
van Corven et al (1992) Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Biochem.J. 281 163 PMID: 1731751
Dottori et al (2008) Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells. Stem Cells 26 1146 PMID: 18308941
Lapierre et al (2010) Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J.Biol.Chem. 285 25792 PMID: 20551326
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Keywords: 1-Oleoyl lysophosphatidic acid sodium salt, 1-Oleoyl lysophosphatidic acid sodium salt supplier, lysophosphatidic, acid, LPA, lysophospholipid, receptors, LPL-R, agonists, Lysophosphatidic, Acid, Receptors, Neural, Stem, Cells, 3854, Tocris Bioscience
1 Citation for 1-Oleoyl lysophosphatidic acid sodium salt
Citations are publications that use Tocris products. Selected citations for 1-Oleoyl lysophosphatidic acid sodium salt include:
Ruprecht et al (2015) Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. J Clin Invest 160 673 PMID: 25679761
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.