1-Oleoyl lysophosphatidic acid sodium salt

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Cat.No. 3854 - 1-Oleoyl lysophosphatidic acid sodium salt | C21H40NaO7P | CAS No. 325465-93-8
Description: Endogenous agonist of LPA1 and LPA2
Chemical Name: 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt
Citations (1)
Reviews (1)

Biological Activity

Endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. Inhibits differentiation of neural stem cells (NSCs) into neurons.

Technical Data

M. Wt 458.5
Formula C21H40NaO7P
Storage Store at -20°C
CAS Number 325465-93-8
PubChem ID 44159357

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
phosphate buffered saline 4.58 10

Preparing Stock Solutions

The following data is based on the product molecular weight 458.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.81 mL 109.05 mL 218.1 mL
0.5 mM 4.36 mL 21.81 mL 43.62 mL
1 mM 2.18 mL 10.91 mL 21.81 mL
5 mM 0.44 mL 2.18 mL 4.36 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

van Corven et al (1992) Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Biochem.J. 281 163 PMID: 1731751

Dottori et al (2008) Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells. Stem Cells 26 1146 PMID: 18308941

Lapierre et al (2010) Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J.Biol.Chem. 285 25792 PMID: 20551326

If you know of a relevant reference for 1-Oleoyl lysophosphatidic acid sodium salt, please let us know.

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Keywords: 1-Oleoyl lysophosphatidic acid sodium salt, 1-Oleoyl lysophosphatidic acid sodium salt supplier, lysophosphatidic, acid, LPA, lysophospholipid, receptors, LPL-R, agonists, Lysophosphatidic, Acid, Receptors, Neural, Stem, Cells, 3854, Tocris Bioscience

1 Citation for 1-Oleoyl lysophosphatidic acid sodium salt

Citations are publications that use Tocris products. Selected citations for 1-Oleoyl lysophosphatidic acid sodium salt include:

Ruprecht et al (2015) Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. J Clin Invest 160 673 PMID: 25679761

Do you know of a great paper that uses 1-Oleoyl lysophosphatidic acid sodium salt from Tocris? Please let us know.

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LPA induces COX-2 expression in MG-63 cells
By Christopher Trummer on 10/23/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Osteosarcoma

MG-63 cells were treated with 10 µM LPA (0-48 h) to follow COX-2 expression using Western blot. LPA induced COX-2 expression in a time-dependent manner in osteosarcoma cells.

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