1-Oleoyl lysophosphatidic acid sodium salt

Pricing Availability Delivery Time Qty
Cat.No. 3854 - 1-Oleoyl lysophosphatidic acid sodium salt | C21H40NaO7P | CAS No. 325465-93-8
Description: Endogenous agonist of LPA1 and LPA2
Chemical Name: 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt
Datasheet
Citations (1)
Literature

Biological Activity

Endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. Inhibits differentiation of neural stem cells (NSCs) into neurons.

Technical Data

M. Wt 458.5
Formula C21H40NaO7P
Storage Store at -20°C
CAS Number 325465-93-8
PubChem ID 44159357
InChI Key XGRLSUFHELJJAB-JGSYTFBMSA-M
Smiles [Na+].CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 4.58 10

Preparing Stock Solutions

The following data is based on the product molecular weight 458.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.91 mL 21.81 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

van Corven et al (1992) Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Biochem.J. 281 163 PMID: 1731751

Dottori et al (2008) Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells. Stem Cells 26 1146 PMID: 18308941

Lapierre et al (2010) Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J.Biol.Chem. 285 25792 PMID: 20551326


If you know of a relevant reference for 1-Oleoyl lysophosphatidic acid sodium salt, please let us know.

View Related Products by Product Action

View all Lysophosphatidic Acid Receptor Agonists

Keywords: lysophosphatidic acid LPA lysophospholipid receptors LPL-R agonists Lysophosphatidic Acid Receptors

1 Citation for 1-Oleoyl lysophosphatidic acid sodium salt

Citations are publications that use Tocris products. Selected citations for 1-Oleoyl lysophosphatidic acid sodium salt include:

Ruprecht et al (2015) Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. J Clin Invest 160 673 PMID: 25679761


Do you know of a great paper that uses 1-Oleoyl lysophosphatidic acid sodium salt from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for 1-Oleoyl lysophosphatidic acid sodium salt

Protocols

TODO: Add Protocols