IBMX

Pricing Availability Delivery Time Qty
Cat.No. 2845 - IBMX | C10H14N4O2 | CAS No. 28822-58-4
Description: PDE inhibitor (non-selective)
Chemical Name: 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Purity: ≥99% (HPLC)
Datasheet
Citations (7)
Literature

Biological Activity

Phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Facilitates differentiation of neural progenitor cells in vitro.

Compound Libraries

IBMX is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 222.24
Formula C10H14N4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 28822-58-4
PubChem ID 3758
InChI Key APIXJSLKIYYUKG-UHFFFAOYSA-N
Smiles O=C1C2=C(N=CN2)N(CC(C)C)C(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.67 75
ethanol 11.11 50

Preparing Stock Solutions

The following data is based on the product molecular weight 222.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.5 mL 22.5 mL 45 mL
5 mM 0.9 mL 4.5 mL 9 mL
10 mM 0.45 mL 2.25 mL 4.5 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Freitag et al (1998) Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits. Eur.J.Pharmacol. 354 67 PMID: 9726632

Lepski et al (2013) cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels. Front.Cell Neurosci. 7 155 PMID: 24065885


If you know of a relevant reference for IBMX, please let us know.

View Related Products by Product Action

View all Phosphodiesterase Inhibitors

Keywords: PDE inhibitors inhibits non-selective Phosphodiesterases Phosphodiesterases

7 Citations for IBMX

Citations are publications that use Tocris products. Selected citations for IBMX include:

Elliott et al (2015) Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130 PMID: 25406263

Cooke et al (2015) Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor. Biomed Res Int 172 593 PMID: 24697554

Ghosh et al (2015) The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia. Eneuro 2015 308461 PMID: 25722974

Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). PLoS One 2 PMID: 26465004

Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. Am J Physiol Lung Cell Mol Physiol 10 e0132884 PMID: 26222156

Cuppoletti et al (2013) Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents. Cell Biochem Biophys 66 53 PMID: 22918821

Hook et al (2012) Dopaminergic modulation of ganglion-cell photoreceptors in rat. Br J Pharmacol 35 507 PMID: 22304466


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Pathways for IBMX

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