TWS 119

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Cat.No. 7405 - TWS 119 | C18H14N4O2 | CAS No. 601514-19-6
Description: Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation
Chemical Name: 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (8)
Pathways (1)

Biological Activity for TWS 119

TWS 119 is a potent inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). TWS 119 inhibits both GSK3α and GSK3β in vitro (IC50 = 88 nM and 410 nM, respectively). TWS 119 induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells at 400 nM. TWS 119 enhances the proliferation and survival of γδ T-cells, and induces differentiation of CD8+ T cells towards a stem cell-like memory T cell phenotype at 2.5 μM.

Technical Data for TWS 119

M. Wt 318.33
Formula C18H14N4O2
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 601514-19-6
PubChem ID 9549289
InChI Key VPVLEBIVXZSOMQ-UHFFFAOYSA-N
Smiles OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TWS 119

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.83 100
ethanol 1.59 5

Preparing Stock Solutions for TWS 119

The following data is based on the product molecular weight 318.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.71 mL 31.41 mL
5 mM 0.63 mL 3.14 mL 6.28 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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References for TWS 119

References are publications that support the biological activity of the product.

Zeng et al (2009) Glycogen synthase kinase 3 regulates PAX3-FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. Biochem.Biophys.Res.Commun. 391 1049 PMID: 19995556

Gattinoni et al (2009) Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808 PMID: 19525962

Forget et al (2012) Stimulation of Wnt/β-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype. PLoS One 7 e41074 PMID: 22859966


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Citations for TWS 119

Citations are publications that use Tocris products.

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Reviews for TWS 119

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

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Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Alzheimer's Poster

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Schizophrenia Poster

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for TWS 119

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.