New Products

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New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the new products can be identified by this symbol symbol.

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Cat.No.
Product Name / Activity
Added
6268Tocriscreen Kinase Inhibitor Toolbox I & II

A library of 160 kinase inhibitor compounds (250 μL 10 mM DMSO solutions)

Apr 2017
6225Tocriscreen Kinase Inhibitor Toolbox II

A library of 80 kinase inhibitor compounds (250 μL 10 mM DMSO solutions)

Apr 2017
6219Arformoterol tartrate

Long-acting β2 agonist (LABA)

Apr 2017
6218Galiellalactone

STAT3 inhibitor; in vivo active

Apr 2017
6217Histone H3 (1-34)

Histone H3 peptide

Apr 2017
6175DBHDA

Reagent for synthetic biology; converts cysteine to dehydroalanine

Apr 2017
6161Ailanthone

Potent inhibitor of androgen receptor (AR)

Apr 2017
6151LDN 212854

Potent bone morphogenetic protein type I (ALK) inhibitor

Apr 2017
5933Tocriscreen Kinase Inhibitor Toolbox I

A library of 80 kinase inhibitor compounds (250 μL 10 mM DMSO solutions)

Apr 2017
574125-Hydroxycholesterol

Antiviral; also α-crystallin (cryAB) chaperone

Apr 2017
5700ML 315 hydrochloride

Inhibitor of Clk and DYRK kinases

Apr 2017
6227TAT-Gap19

Cx43 hemichannel blocker

Apr 2017
6216H3K4(Me3) (1-20)

Histone H3 peptide; substrate for methyltransferase/demethylase enzymes

Apr 2017
6214H3K4(Me) (1-20)

Histone H3 peptide; substrate for methyltransferase/demethylase enzymes

Apr 2017
6213H3K27(Me3) (15-34)

Histone H3 peptide; substrate for methyltransferase/demethylase enzymes

Apr 2017
6212H3K27(Me2) (15-34)

Histone H3 peptide; substrate for methyltransferase/demethylase enzymes

Apr 2017
6211H3K27(Me) (15-34)

Histone H3 peptide; substrate for demethylase/methyltransferase enzymes

Apr 2017
6190Retrobradykinin

Reverse analog of Bradykinin

Apr 2017
6157cis VH 298

Negative control for VH 298

Apr 2017
6156VH 298

High-affinity inhibitor of VHL

Apr 2017
6155cis MZ 1

Negative Control for MZ1

Apr 2017
6154MZ 1

(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells.

Apr 2017
5976Ned K

NAADP signaling inhibitor

Apr 2017
5729TASP 0390325

Potent and selective V1B receptor antagonist; orally bioavailable

Apr 2017
6253F 127 (20% solution in DMSO)

Nonionic detergent

Apr 2017
6234Entecavir

Potent and selective hepatitis B virus inhibitor

Apr 2017
6202Vilazodone hydrochloride

Potent 5-HT1A partial agonist and SSRI; antidepressant

Apr 2017
6188Everolimus

mTOR inhibitor;immunosuppressant

Apr 2017
6180NMS 873

Potent and selective valosine containing protein (VCP; p97) allosteric inhibitor

Apr 2017
6168RI 1

RAD51 recombinase inhibitor

Apr 2017
6150PA Janelia Fluor™ 646, SE

Photoactivatable cell permeable fluorescent dye; supplied as NHS ester

Apr 2017
6149PA Janelia Fluor™ 549, SE

Photoactivatable cell permeable fluorescent dye; supplied as NHS ester

Apr 2017
6009B I09

IRE1 endonuclease inhibitor; cell permeable

Apr 2017
5987(±)-ML 209

RORγt inverse agonist; suppresses Th17 cell differentiation

Apr 2017
6264Caerulein

CCK agonist

Mar 2017
6221PKI (5-24)

High affinity PKA inhibitor

Mar 2017
6105TC AC 28

High affinity BET bromodomain ligand

Mar 2017
5865KLH 45

Potent DDHD2 inhibitor

Mar 2017
5437Cyanine 7, SE

Near-infrared fluorescent dye for labeling of amines

Mar 2017
5435Cyanine 3, SE

Orange fluorescent dye for labeling of amines

Mar 2017
6250Filipin III

Polyene antibiotic; inhibits formation of pathological isoform of prion protein

Mar 2017
6233Retigabine

KV7 channel activator

Mar 2017
6171MLS 1547

G protein-biased D2 receptor partial agonist

Mar 2017
6092TDZD 8

Selective non-ATP competitive inhibitor of GSK 3β

Mar 2017
6232Bosentan

High affinity dual ETA and ETB receptor antagonist;orally bioavailable

Mar 2017
6210ci-IP3/PM

Caged inositol triphosphate

Mar 2017
62047-Ethoxyresorufin

Fluorometric CYP450 substrate

Mar 2017
6146LAP

Photocrosslinker for hydrogels

Mar 2017
6107CP 424174

Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3

Mar 2017
6086AMP PNP

Kir6 blocker; non-hydrolyzable AMP analog

Mar 2017
6047BOP

Dual α9β/1α4β1 integrin inhibitor; preferentially mobilizes HSCs

Mar 2017
5932Tocriscreen Library of FDA-Approved Compounds

A library of 160 FDA-approved compounds (250 μL 10 mM DMSO solutions)

Mar 2017
5758AGN 193109

High affinity pan-RAR antagonist

Mar 2017
5720AR-C 69931 tetrasodium salt

Highly potent P2Y12 antagonist

Mar 2017
5407GA3-AM

Gibberellin-analog (GA3) chemical dimerizer; cell permeable

Mar 2017
6138SR 9243

Selective LXR inverse agonist

Mar 2017
5872AZ 10397767

Potent CXCR2 antagonist

Mar 2017
5300BI 605906

Selective IKKβ inhibitor

Mar 2017
6176FTY 720

Potent S1P receptor agonist; also immunosuppresant

Feb 2017
6170Cinacalcet hydrochloride

Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

Feb 2017
6101SHIP 2a

Cystathione γ lyase (CSE) inhibitor

Feb 2017
6088SB 3CT

Selective high affinity MMP2 inhibitor

Feb 2017
5986NAV 2729

Selective ARF6 inhibitor

Feb 2017
5881Bicine

General purpose buffer

Feb 2017
5879ACES

Zwitterionic buffer

Feb 2017
5873CAPS

Buffer widely used in Western blotting

Feb 2017
5846IT 901

NF-κB c-Rel subunit inhibitor

Feb 2017
5785MDNI-caged-L-glutamate

Stable photoreleaser of L-glutamate

Feb 2017
5672GSK 319347A

Potent and selective IKKε inhibitor

Feb 2017
5419PCNA I1

PCNA inhibitor

Feb 2017
5850HM 50316

High affinity FABP4 inhibitor

Feb 2017
6169PF 06726304 acetate

Highly potent and SAM-competitive EZH2 inhibitor

Feb 2017
6082AMG 837 hemicalcium salt

Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist

Feb 2017
6029FRAX 597

Potent group I PAK inhibitor

Feb 2017
5911FFN 200 dihydrochloride

Selective fluorescent VMAT2 substrate

Feb 2017
5777GSK 591 dihydrochloride

Potent and selective PRMT5 inhibitor

Feb 2017
6148Janelia Fluor™ 646, SE

Cell permeable fluorescent dye; supplied as NHS ester

Feb 2017
6147Janelia Fluor™ 549, SE

Cell permeable fluorescent dye; supplied as NHS ester

Feb 2017
6111Zoledronic Acid

Potent farnesyl diphosphate (FPP) synthase inhibitor

Feb 2017
5943ML 339

Potent and selective hCXCR6 antagonist

Feb 2017
5780MRT 68921 dihydrochloride

Potent ULK inhibitor; inhibits autophagy

Feb 2017
5362TASP 0433864

Selective mGlu2 receptor positive allosteric modulator

Feb 2017
61594,9-Anhydrotetrodotoxin

Potent and selective Nav1.6 channel blocker

Jan 2017
61378-Cyclopentyl-1,3-dimethylxanthine

High affinity adenosine A1 receptor antagonist

Jan 2017
6131(R)-Modafinil

Dopamine uptake inhibitor

Jan 2017
6034AM 2394

Potent glucokinase activator; orally bioavailable

Jan 2017
5993CP 673451

Potent and selective PDGFR inhibitor

Jan 2017
5955eCF 309

Potent mTOR inhibitor

Jan 2017
5692ITH 12575

Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor.

Jan 2017
5518UMB 68

GHB receptor ligand

Jan 2017
6124(R)-2-Hydroxyglutaric acid disodium salt

KDM4A inhibitor; also NF-κB activator

Jan 2017
6117CORM 2

Carbon monoxide-releasing molecule

Jan 2017
6108Galeterone

CYP17 inhibitor; also androgen receptor antagonist

Jan 2017
6085AZD 1283

High affinity P2Y12 antagonist

Jan 2017
6077DETA NONOate

Nitric oxide donor

Jan 2017
6056GSK 1363089

Potent inhibitor of MET, VEGFR2, Ron and AXL

Jan 2017
6008TP 064

Potent and selective PRMT 4 inhibitor

Jan 2017
6005PF 3758309 dihydrochloride

Potent PAK4 inhibitor; orally available

Jan 2017
5999TP 472N

Negative control for TP 472 (Cat. No. 6000).

Jan 2017
5934NCT 501 hydrochloride

Potent and selective ALDH1A1 inhibitor

Jan 2017
5833Ex 26

Potent and selective S1P1 receptor antagonist

Jan 2017
5632AZ Dyrk1B 33

Potent and selective Dyrk1B kinase inhibitor

Jan 2017
6112(S)-Norketamine hydrochloride

NMDA receptor modulator; analgesic

Jan 2017
60952S,6S-Hydroxynorketamine hydrochloride

Decreases D-serine (a NMDA co-agonist); antidepressant

Jan 2017
60942R,6R-Hydroxynorketamine hydrochloride

Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects

Jan 2017
5996(R)-Norketamine hydrochloride

NMDA receptor modulator; analgesic

Jan 2017
5966ML 233

Non-peptide apelin receptor agonist

Jan 2017
4991HaXS8

Chemical dimerizer

Jan 2017
6115PF 06273340

Potent and selective pan-Trk inhibitor; peripherally restricted

Jan 2017
6114PF 06409577

Potent and selective allosteric activator of AMPK

Jan 2017
6063CCF 642

Protein disulfide isomerase (PDI) inhibitor

Jan 2017
6014Org 48762-0

Selective p38α/β inhibitor; orally bioavailable

Jan 2017
5978WL 47 - dimer

High affinity caveolin-1 ligand

Jan 2017
6087Perifosine

PKB/Akt inhibitor; also modulates Kv2.1 current

Dec 2016
6066OAC-2

Oct4 activator; enhances iPSC reprogramming efficiency

Dec 2016
5488BML 111

FPR2 (lipoxin A4 receptor) agonist

Dec 2016
6052BAY 58-2667 hydrochloride

Potent soluble guanylyl cyclase (sGC) activator

Dec 2016
6030Amylin (rat)

Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors

Dec 2016
6015RAF 265

Raf kinase and VEGFR-2 inhibitor

Dec 2016
6000TP 472

Potent BRD9/7 inhibitor

Dec 2016
5813NSC 668036

Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein

Dec 2016
5312BRACO 19 trihydrochloride

Telomerase inhibitor

Dec 2016
5125CKD 602

Topoisomerase I inhibitor

Dec 2016
6076Ani 9

Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker

Dec 2016
6071CZC 25146

Potent LRRK2 inhibitor

Dec 2016
6031Calcitonin (human)

Endogenous calcitonin receptor agonist; inhibits bone resorption

Dec 2016
5970BAY 299

Potent and selective BRD1 and TAF1 inhibitor

Dec 2016
5968Ro 3280

Potent and selective PLK1 inhibitor

Dec 2016
6070Pladienolide B

mRNA splicing inhibitor; antitumor

Nov 2016
6058ATN 161

α5β1 integrin receptor antagonist

Nov 2016
6053LDN 193189 dihydrochloride

Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs

Nov 2016
6046Naloxone fluorescein acetate

Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599)

Nov 2016
59623-AP

Ribonucleotide reductase inhibitor; also an iron chelator

Nov 2016
5952PDD 00017273

Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeable

Nov 2016
5909RMM 46

MSK/RSK family kinase inhibitor

Nov 2016
5908Bis-ANS

Fluorescent probe for nonpolar cavities in proteins; used to detect Aβ fibres

Nov 2016
5791Bz 423

ATP synthase inhibitor; proapoptotic

Nov 2016
5436Cyanine 5, SE

Red fluorescent dye for the labeling of amines

Nov 2016
5282SAG 21k

Hedgehog signaling activator; brain penetrant and orally bioavailable

Nov 2016
6090Spexin

Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo

Nov 2016
6011FSL 1

TLR2/6 agonist (also a putative TLR10 ligand)

Nov 2016
5834LTURM 34

Potent DNA-PK inhibitor

Nov 2016
5756MLi-2

Potent and selective LRRK2 inhibitor

Nov 2016
6033(R)-MG 132

Potent 20S proteasome inhibitor

Nov 2016
6019Diprotin A

Dipeptidyl peptidase IV (DPP-IV) inhibitor

Nov 2016
5851JZP 361

Potent and selective reversible MAGL inhibitor

Nov 2016
5804Chaetoglobosin A

Antibiotic; selectively induces apoptosis of CLL cells

Nov 2016
5724NQ 301

Selective CD45 inhibitor

Nov 2016
6068Lin28 1632

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Nov 2016
60652-NBDG

Fluorescent glucose uptake indicator

Nov 2016
6001ZQ 16

Selective GPR84 agonist

Nov 2016
5915PF 04449613

Potent PDE9 inhibitor; brain penetrant

Nov 2016
5843AX 15836

Potent and selective ERK5 inhibitor

Nov 2016
5779NSC 23005 sodium

Potently promotes HSC expansion ; p18INK inhibitor

Nov 2016
5561IHR-Cy3

Potent fluorescent Smo antagonist

Nov 2016
4447Org 24598

Inhibitor of GlyT1; derivative of Org 24598 (Cat. No. 4035).

Nov 2016
6043AMBMP hydrochloride

Wnt canonical signaling activator; also tubulin polymerization inhibitor

Nov 2016
5992MM 54

Potent apelin receptor antagonist

Nov 2016
5913Ro 6842262

Potent LPA1 antagonist

Nov 2016
5835LTURM 36

PI 3-kinase δ inhibitor

Nov 2016
5824Hoechst 33258

Fluorescent dye for labeling DNA

Nov 2016
5995AMG 517

Potent TRPV1 antagonist

Oct 2016
5919PI 3065

Potent and selective PI 3-kinase p110δ inhibitor

Oct 2016
5701AMG 853

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

Oct 2016

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