New Products

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New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the new products can be identified by this symbol symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Cat.No.
Product Name / Activity
Added
5951WAY 252623

Potent LXR agonist

Jul 2016
5866PH 797804

Potent and selective p38α/β inhibitor

Jul 2016
5841Tocriscreen Plus Mini

A library of 1280 biologically active compounds (50 μL 10mM DMSO solutions)

Jul 2016
5840Tocriscreen Plus

A library of 1280 biologically active compounds (250 μL 10mM DMSO solutions)

Jul 2016
5803MP A08

Selective ATP competitive SphK1 and 2 inhibitor; cell permeable

Jul 2016
5719SKF 82958 hydrobromide

D1 agonist

Jul 2016
5650SAR 216471 hydrochloride

Potent P2Y12 antagonist; cell permeable

Jul 2016
5982cis-6-Hydroxynorketamine hydrochloride

Metabolite of ketamine (Cat.No. 3131); antidepressive

Jul 2016
5958Desloratadine

High affinity H1 antagonist; anti-inflammatory.

Jul 2016
5917PF 9184

Potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor

Jul 2016
5867Ceefourin 1

Selective MRP4 inhibitor

Jul 2016
5855SR 9009

Rev-Erbα/β agonist

Jul 2016
5809SPL 334

S-Nitrosoglutathione reductase inhibitor

Jul 2016
5799Mitoglitazone

Insulin sensitizer; exhibits low binding affinity at PPARγ

Jul 2016
5794LM 10

Selective tryptophan 2,3-dioxygenase (TDO) inhibitor

Jul 2016
5747Apcin

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Jul 2016
5311RHPS 4 methosulfate

Telomerase inhibitor

Jul 2016
5929BeKm 1

Potent and selective KV11.1 (hERG) channel blocker

Jun 2016
5775AZ 6102

Potent TNKS1/2 inhibitor

Jun 2016
5773Akti-1/2

Potent and selective dual Akt1 and 2 inhibitor

Jun 2016
5693VU 0409551

Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable

Jun 2016
5667YK 3-237

SIRT1 activator

Jun 2016
59463',3'-cGAMP sodium salt

STING agonist

Jun 2016
59452',3'-cGAMP sodium salt

Endogenous high affinity STING agonist

Jun 2016
5939PF 6274484

High affinity and potent covalent EGFR kinase inhibitor

Jun 2016
5931PF 05089771

Potent and selective Nav1.7 channel blocker

Jun 2016
5766A 971432

Potent and selective S1P5 agonist

Jun 2016
5621GLPG 0974

Potent FFA2 antagonist

Jun 2016
5590BI 9564

Potent and selective BRD9 and BRD7 inhibitor; orally active

Jun 2016
5445SM 324405

Potent TLR7 agonist

Jun 2016
5941OD1

Potent hNav1.4, rNav1.6 and rNav1.7 channel activator

Jun 2016
5940AdTx1

Selective, high affinity, non-competitive α1A adrenoceptor antagonist

Jun 2016
5938Mambalgin 1

Selective ASIC1a inhibitor; analgesic

Jun 2016
5930PBIT

JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor

Jun 2016
5916Canertinib dihydrochloride

Potent EGFR kinase inhibitor

Jun 2016
5869CDN 1163

SERCA2 allosteric activator

Jun 2016
5856Ritonavir

HIV-1 and HIV-2 protease inhibitor

Jun 2016
5781A 425619

Potent TRPV1 antagonist

Jun 2016
5707RA 839

Nrf2 activator; inhibits Nrf2/Keap1 interaction

Jun 2016
5671SB 332235

Potent CXCR2 antagonist

Jun 2016
5937A 779

Selective Mas receptor (Ang-(1-7) receptor) antagonist

Jun 2016
5928RS 09

TLR4 peptide agonist; acts as an adjuvant in vivo

Jun 2016
5852Acetyl Pepstatin

High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinases

Jun 2016
5837[Pro3]-GIP (Rat)

High affinity rat GIP receptor partial agonist

Jun 2016
5800CHMFL-FLT3-122

Potent and selective FLT3 inhibitor

Jun 2016
5838[Pro3]-GIP (Mouse)

GIP receptor antagonist

Jun 2016
5774DEL 22379

ERK dimerization inhibitor

Jun 2016
5722Ogerin

Selective positive allosteric modulator at GPR68

Jun 2016
5464AC 4

Photoswitchable TRPV1 channel blocker

Jun 2016
4503CC 0651

Allosteric inhibitor of hCdc34

Jun 2016
5839XEN 445

Selective endothelial lipase inhibitor; orally bioavailable

May 2016
5760P-3FAX-Neu5Ac

Sialic acid analog; sialyltransferase inhibitor

May 2016
5664O4I2

Oct3/4 inducer; induces expression of pluripotent-associated genes

May 2016
5655GN 44028

Potent HIF-1α inhibitor

May 2016
5907VX 680

High affinity and selective Aurora kinase inhibitor

May 2016
5906Imatinib mesylate

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

May 2016
5857Neuropeptide S (Mouse)

Potent endogenous neuropeptide S receptor (NPSR) agonist

May 2016
5806ISOX DUAL

Dual BRD4 and CBP/p300 bromodomain inhibitor

May 2016
5738ML 382

MrgX1 (SNSR4) positive allosteric modulator

May 2016
5678RN 9893 hydrochloride

Potent and selective TRPV4 antagonist

May 2016
5651ONO 6818

High affinity and selective human neutraphil elastase 1 (HNE1) inhibitor; orally active

May 2016
5830K-(D-1-Nal)-FwLL-NH2

High affinity and potent ghrelin receptor inverse agonist

May 2016
5808ISOX INACT

Negative control for PF-CBP1 (Cat. No. 5801)

May 2016
5327BGC 20-1531 hydrochloride

High affinity and selective EP4 antagonist

May 2016
5904Montelukast sodium

CysLT1 antagonist

May 2016
5902Tiotropium bromide

Potent muscarinic receptor antagonist

May 2016
5864Tolcapone

COMT inhibitor; also inhibits transthyretin aggregation

May 2016
5854SR 9238

Potent and selective LXR inverse agonist

May 2016
5832TGX 221

Potent and selective PI 3-kinase β inhibitor

May 2016
5817BSI 201

PARP-1 inhibitor

May 2016
5754PF 543 hydrochloride

Potent and selective SphK1 inhibitor

May 2016
5714S 2101

LSD1 inhibitor

May 2016
5901c-Di-AMP sodium salt

Endogenous STING and DDX41 agonist; activates STING-dependent signaling

Apr 2016
5871pCPA methyl ester hydrochloride

Tryptophan hydroxylase inhibitor

Apr 2016
5859Neuropeptide S (Rat)

Potent endogenous neuropeptide S receptor agonist

Apr 2016
5858Droperidol

D2 receptor antagonist

Apr 2016
5853JNJ DGAT2-A

DGAT2 inhibitor

Apr 2016
5848NoxA1ds

Potent and selective NADPH oxidase 1 (NOX1) inhibitor

Apr 2016
5845JX 06

Potent and selective PDK1/2/3 inhibitor

Apr 2016
5811NBD 556

CD4 mimetic; blocks HIV-1 cell entry

Apr 2016
5795ATI 2341

CXCR4 allosteric agonist

Apr 2016
5725ML 352 hydrochloride

High affinity and selective presynaptic choline transporter (CHT) inhibitor

Apr 2016
5365LLY 507

Potent SMYD2 inhibitor

Apr 2016
5067MRT 68601 hydrochloride

Potent TBK1 inhibitor

Apr 2016
2587Neuropeptide S (human)

Potent endogenous neuropeptide S receptor agonist

Apr 2016
5900c-Di-GMP sodium salt

Endogenous STING and DDX41 agonist; activates STING-dependent signaling

Apr 2016
5836CBR 5884

3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor

Apr 2016
5825CHAPSO

Zwitterionic detergent

Apr 2016
5737BAM 15

Mitochondrial protonophore uncoupler

Apr 2016
5351PQ 69

Potent and selective A1 antagonist/inverse agonist

Apr 2016
5810RS 1

High affinity RAD51 activator; also CRISPR enhancer

Apr 2016
57406-Hydroxy-DL-DOPA

Allosteric inhibitor of RAD52; also APE1 inhibitor

Apr 2016
5699IP7e

Potent Nurr1 activator

Apr 2016
5801PF CBP1

Selective CBP/p300 bromodomain inhibitor

Apr 2016
5796Azoramide

Unfolded protein response (UPR) modulator

Mar 2016
57654-azido-N-ethyl-1,8-naphthalimide

Click-activated fluorescent probe

Mar 2016
5681N106

Activator of SUMO-activating enzyme, E1 ligase

Mar 2016
5301BPTES

Selective allosteric glutaminase (GLS1) inhibitor

Mar 2016
5039SR 144528

High affinity and selective CB2 inverse agonist

Mar 2016
4568CPYPP

DOCK2-Rac1 interaction inhibitor

Mar 2016
5668VUF 11222

High affinity non-peptide CXCR3 agonist

Mar 2016
5592LCB 03-0110 dihydrochloride

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

Mar 2016
5100TC-T 6000

Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor

Mar 2016
5083QO 58

Kv7 channel opener

Mar 2016
4968CCT 241533 dihydrochloride

Potent Chk2 inhibitor

Mar 2016
4180Beraprost sodium

Potent prostacyclin IP receptor agonist

Mar 2016
5823Ala-Gln

Stable form of L-glutamine; commonly used in cell culture

Mar 2016
5819Bexarotene

Potent and selective RXR agonist

Mar 2016
5792ProTx III

Potent Nav1.7 blocker; analgesic

Mar 2016
5646EML 425

Reversible and non-competitive p300/CBP inhibitor

Mar 2016
5790PF 05175157

Acetyl-CoA carboxylase (ACC) 1 and 2 inhibitor

Mar 2016
5769TM 5275 sodium salt

Plasminogen activator inhibitor-1 (PAI-1) inhibitor; orally bioavailable

Mar 2016
5666JNJ 63533054

Potent and selective GPR139 agonist

Mar 2016
5665IRAK1/4 Inhibitor I

IRAK4 and IRAK1 inhibitor

Mar 2016
5660NVP CXCR2 20

Potent and selective CXCR2 antagonist

Mar 2016
5557Dianicline

Selective α4β2 nAChR partial agonist

Mar 2016
5798Irbesartan

Potent AT1 antagonist

Mar 2016
5772Sacubitril calcium

Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable

Mar 2016
5759SW 033291

High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation

Mar 2016
5694GSK 2033

Potent LXR antagonist

Mar 2016
5687Centrinone

High affinity and selective PLK4 inhibitor

Mar 2016
5661666-15

Potent and selective CREB inhibitor

Mar 2016
5615AZD 3147

Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailable

Mar 2016
4707MI 2 dihydrochloride

Menin-MLL interaction inhibitor

Mar 2016
5751PF 3084014 hydrobromide

Potent γ-secretase inhibitor

Feb 2016
5702DiD perchlorate

Lipophilic fluorescent reagent; shown to stain HSCs

Feb 2016
5673GW 2580

Selective cFMS kinase inhibitor; orally bioavailable

Feb 2016
5579Tilfrinib

Potent and selective breast tumor kinase (Brk) inhibitor

Feb 2016
57782-Phospho-L-ascorbic acid trisodium salt

Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs

Feb 2016
5748DAPI

Fluorescent DNA stain

Feb 2016
5614AZD 2066

mGlu5 antagonist; orally bioavailable and brain penetrant

Feb 2016
4645Z-VRPR-FMK trifluoroacetate salt

Irreversible MALT1 inhibitor

Feb 2016
390727-Hydroxycholesterol

LXR agonist; also ER partial agonist

Feb 2016
5728EXP 3174

Potent and selective AT1 receptor antagonist

Feb 2016
5685MS049 oxalate salt

Potent and selective PRMT4 and PRMT6 inhibitor

Feb 2016
5599ML 18

BRS-3 antagonist; also GRPR agonist

Feb 2016
54415-TAMRA SE

Fluorescent probe for DNA and RNA; also shown to stain telomeres

Feb 2016
5764Deferoxamine mesylate

Iron chelator; also hypoxia mimetic

Feb 2016
5763(R)-Citalopram oxalate

Enantiomer of escitalopram oxalate (Cat. No. 1427)

Feb 2016
5752PF 06260933 dihydrochloride

MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK

Feb 2016
5647MI 192

Potent and selective HDAC2/3 inhibitor

Feb 2016
5645IPSU

OX2 receptor antagonist; orally bioavailable

Feb 2016
5739Prostratin

PKC activator; also NF-κB activator

Jan 2016
5735S3QEL 2

Suppressor of complex III superoxide production

Jan 2016
5734L-Dehydroascorbic acid

GLUT1 substrate; oxidized form of L-Ascorbic acid

Jan 2016
5656DY 268

Potent FXR antagonist

Jan 2016
5642CMPD101

Potent and selective GRK2/3 inhibitor

Jan 2016
5459Cytosporone B

High affinity Nur77 agonist

Jan 2016

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