New Products

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New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the new products can be identified by this symbol symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Cat.No.
Product Name / Activity
Added
6070Pladienolide B

mRNA splicing inhibitor; antitumor

Nov 2016
6058ATN 161

α5β1 integrin receptor antagonist

Nov 2016
6053LDN 193189 dihydrochloride

Potent and selective ALK2 and ALK3 inhibitor; induces neural induction of hPSCs

Nov 2016
6046Naloxone fluorescein acetate

Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599)

Nov 2016
59623-AP

Ribonucleotide reductase inhibitor; also an iron chelator

Nov 2016
5952PDD 00017273

Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeable

Nov 2016
5909RMM 46

MSK/RSK family kinase inhibitor

Nov 2016
5908Bis-ANS

Fluorescent probe for nonpolar cavities in proteins; used to detect Aβ fibres

Nov 2016
5791Bz 423

ATP synthase inhibitor; proapoptotic

Nov 2016
5436Cyanine 5, SE

Red fluorescent dye for the labeling of amines

Nov 2016
5282SAG 21k

Hedgehog signaling activator; brain penetrant and orally bioavailable

Nov 2016
6090Spexin

Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo

Nov 2016
6011FSL 1

TLR2/6 agonist (also a putative TLR10 ligand)

Nov 2016
5834LTURM 34

Potent DNA-PK inhibitor

Nov 2016
5756MLi-2

Potent and selective LRRK2 inhibitor

Nov 2016
6033(R)-MG 132

Potent 20S proteasome inhibitor

Nov 2016
6019Diprotin A

Dipeptidyl peptidase IV (DPP-IV) inhibitor

Nov 2016
5851JZP 361

Potent and selective reversible MAGL inhibitor

Nov 2016
5804Chaetoglobosin A

Antibiotic; selective apoptosis inducer of CLL cells

Nov 2016
5724NQ 301

Selective CD45 inhibitor

Nov 2016
6068Lin28 1632

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Nov 2016
60652-NBDG

Fluorescent glucose uptake indicator

Nov 2016
6001ZQ 16

Selective GPR84 agonist

Nov 2016
5915PF 04449613

Potent PDE9 inhibitor; brain penetrant

Nov 2016
5843AX 15836

Potent and selective ERK5 inhibitor

Nov 2016
5779NSC 23005 sodium

Potently promotes HSC expansion ; p18INK inhibitor

Nov 2016
5561IHR-Cy3

Potent fluorescent Smo antagonist

Nov 2016
4447Org 24598

Inhibitor of GlyT1; derivative of Org 24598 (Cat. No. 4035).

Nov 2016
6043AMBMP hydrochloride

Wnt canonical signaling activator; also tubulin polymerization inhibitor

Nov 2016
5992MM 54

Potent apelin receptor antagonist

Nov 2016
5913Ro 6842262

Potent LPA1 antagonist

Nov 2016
5835LTURM 36

PI 3-kinase δ inhibitor

Nov 2016
5824Hoechst 33258

Fluorescent dye for labeling DNA

Nov 2016
5995AMG 517

Potent TRPV1 antagonist

Oct 2016
5919PI 3065

Potent and selective PI 3-kinase p110δ inhibitor

Oct 2016
5701AMG 853

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

Oct 2016
6020URB 602

Non-competitive MAGL inhibitor

Oct 2016
5761RG 102240

Gene switch ligand for use in induceable gene expression systems

Oct 2016
5742AZ PFKFB3 67

Potent and selective PFKFB3 inhibitor

Oct 2016
5708BAY 41-8543

Guanylyl cyclase (sGC) stimulator

Oct 2016
6025(S)-Crizotinib

Potent MTH1 inhibitor

Oct 2016
6010BRD 4354

HDAC5 and HDAC9 inhibitor

Oct 2016
5983BMS 986187

Potent δ-opioid receptor positive allosteric modulator

Oct 2016
5789AM 4668

Potent FFA1 (GPR40) agonist

Oct 2016
5570STOCK2S 26016

Lysine deficient protein kinase (WNK) signaling inhibitor

Oct 2016
5965ISAM 140

High affinity A2B receptor antagonist

Oct 2016
5762BMS 795311

Potent cholesteryl ester transfer protein (CETP) inhibitor

Oct 2016
5695Eggmanone

Potent and selective PDE4 inhibitor; suppresses hedgehog signaling

Oct 2016
6044AS 8351

Induces reprogramming of fibroblasts into functional cardiomyocytes

Sep 2016
5903CATPB

FFA2 antagonist/inverse agonist

Sep 2016
6003PF 05105679

Selective TRPM8 blocker

Sep 2016
5770MONNA

Potent TMEM16A (Anoctamin-1) blocker

Sep 2016
6026Oleanolic acid

Selective GPBA receptor (TGR5) partial agonist

Sep 2016
6004PF 06281355

Selective myeloperoxidase (MPO) inhibitor

Sep 2016
5954MSG 606

Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist

Sep 2016
4546rac-CCT 250863

Potent Nek2 inhibitor

Sep 2016
6006Acein

High affinity angiotensin-converting enzyme (ACE) ligand

Sep 2016
5849EC 19

Synthetic retinoid; induces differentiation of stem cells

Sep 2016
5715(±)-ADX 71743

Negative allosteric modulator at mGlu7; brain penetrant

Sep 2016
1332Roscovitine

Potent, selective cyclin-dependent kinase inhibitor

Sep 2016
6007INCB 024360-analog

Potent indoleamine 2,3-dioxygenase (IDO) inhibitor

Aug 2016
5905Neurosensor 521

Selective noradrenalin and dopamine fluorescent indicator

Aug 2016
5744NVS-CECR2-1

Potent and selective inhibitor of cat eye syndrome chromosome region, candidate 2 (CECR2)

Aug 2016
5944G10

Activator of STING-dependent signaling

Aug 2016
5918TPPU

Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrant

Aug 2016
5994Enzastaurin

Potent PKCβ inhibitor

Aug 2016
5964SI-2 hydrochloride

Steroid receptor coactivator 3 (SRC-3) inhibitor

Aug 2016
5961HIOC

Selective TrkB receptor agonist; neuroprotectant

Aug 2016
5960TMI 1

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

Aug 2016
5935H2DCFDA

Fluorescent ROS indicator; cell permeable

Aug 2016
5870Cilengitide

Potent and selective inhibitor of integrins αvβ3 and αvβ5

Aug 2016
5802A37

ALDH1A1 inhibitor

Aug 2016
5654BMS 265246

Potent cdk1/2 inhibitor

Aug 2016
5244TC-E 5008

Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor; phenotypically lethal

Aug 2016
5166Perhexiline maleate

Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor

Aug 2016
5979Eicosapentaenoic Acid

Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation

Aug 2016
5959Autocamtide-2-related inhibitory peptide, myristoylated

CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide

Aug 2016
5953Adaptaquin

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

Aug 2016
5868SR 0987

T cell-specific RORγ (RORγt) agonist

Aug 2016
5757Tariquidar dihydrochloride

Potent P-glycoprotein (P-gp) inhibitor

Aug 2016
4862PPTN hydrochloride

High affinity and selective P2Y14 antagonist

Aug 2016
5981Itraconazole

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

Aug 2016
4397AV 412

Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases

Aug 2016
6002Trolox

Antioxidant vitamin E derivative

Jul 2016
5989BIRB 796

High affinity and selective p38 kinase inhibitor

Jul 2016
5973CP 724714

Potent and selective ErbB2 inhibitor

Jul 2016
5844JZP 430

Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor

Jul 2016
5807M 084 hydrochloride

TRPC4/5 channel blocker; antidepressant and anxiolytic

Jul 2016
5786NI 42

High affinity BRPF inhibitor

Jul 2016
5727MC 1742

Potent class I and IIb HDAC inhibitor

Jul 2016
5713MS 023 dihydrochloride

Potent and selective type I PRMT inhibitor

Jul 2016
5625ML 334

Inhibitor of Keap1- Nrf2 interaction

Jul 2016
5018PEAQX tetrasodium salt

Potent NMDA receptor antagonist; NR2A selective

Jul 2016
5951WAY 252623

Potent LXR agonist

Jul 2016
5866PH 797804

Potent and selective p38α/β inhibitor

Jul 2016
5841Tocriscreen Plus Mini

A library of 1280 biologically active compounds (50 μL 10mM DMSO solutions)

Jul 2016
5840Tocriscreen Plus

A library of 1280 biologically active compounds (250 μL 10mM DMSO solutions)

Jul 2016
5803MP A08

Selective ATP competitive SphK1 and 2 inhibitor; cell permeable

Jul 2016
5719SKF 82958 hydrobromide

D1 agonist

Jul 2016
5650SAR 216471 hydrochloride

Potent P2Y12 antagonist; orally available

Jul 2016
5982cis-6-Hydroxynorketamine hydrochloride

Metabolite of ketamine (Cat.No. 3131); antidepressive

Jul 2016
5958Desloratadine

High affinity H1 antagonist; anti-inflammatory.

Jul 2016
5917PF 9184

Potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor

Jul 2016
5867Ceefourin 1

Selective MRP4 inhibitor

Jul 2016
5855SR 9009

Rev-Erbα/β agonist

Jul 2016
5809SPL 334

S-Nitrosoglutathione reductase inhibitor

Jul 2016
5799Mitoglitazone

Insulin sensitizer; exhibits low binding affinity at PPARγ

Jul 2016
5794LM 10

Selective tryptophan 2,3-dioxygenase (TDO) inhibitor

Jul 2016
5747Apcin

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Jul 2016
5311RHPS 4 methosulfate

Telomerase inhibitor

Jul 2016
5929BeKm 1

Potent and selective KV11.1 (hERG) channel blocker

Jun 2016
5775AZ 6102

Potent TNKS1/2 inhibitor

Jun 2016
5773Akti-1/2

Potent and selective dual Akt1 and 2 inhibitor

Jun 2016
5693VU 0409551

Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable

Jun 2016
5667YK 3-237

SIRT1 activator

Jun 2016
59463',3'-cGAMP sodium salt

STING agonist

Jun 2016
59452',3'-cGAMP sodium salt

Endogenous high affinity STING agonist

Jun 2016
5939PF 6274484

High affinity and potent covalent EGFR kinase inhibitor

Jun 2016
5931PF 05089771

Potent and selective Nav1.7 channel blocker

Jun 2016
5766A 971432

Potent and selective S1P5 agonist

Jun 2016
5621GLPG 0974

Potent FFA2 antagonist

Jun 2016
5590BI 9564

Potent and selective BRD9 and BRD7 inhibitor; orally active

Jun 2016
5445SM 324405

Potent TLR7 agonist

Jun 2016
5941OD1

Potent hNav1.4, rNav1.6 and rNav1.7 channel activator

Jun 2016
5940AdTx1

Selective, high affinity, non-competitive α1A adrenoceptor antagonist

Jun 2016
5938Mambalgin 1

Selective ASIC1a inhibitor; analgesic

Jun 2016
5930PBIT

JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor

Jun 2016
5916Canertinib dihydrochloride

Potent EGFR kinase inhibitor

Jun 2016
5869CDN 1163

SERCA2 allosteric activator

Jun 2016
5856Ritonavir

HIV-1 and HIV-2 protease inhibitor

Jun 2016
5781A 425619

Potent TRPV1 antagonist

Jun 2016
5707RA 839

Nrf2 activator; inhibits Nrf2/Keap1 interaction

Jun 2016
5671SB 332235

Potent CXCR2 antagonist

Jun 2016
5937A 779

Selective Mas receptor (Ang-(1-7) receptor) antagonist

Jun 2016
5928RS 09

TLR4 peptide agonist; acts as an adjuvant in vivo

Jun 2016
5852Acetyl Pepstatin

High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinases

Jun 2016
5837[Pro3]-GIP (Rat)

High affinity rat GIP receptor partial agonist

Jun 2016
5800CHMFL-FLT3-122

Potent and selective FLT3 inhibitor

Jun 2016

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Bio-Techne Events

ASCB 2016

ASCB 2016

December 3 - 7, 2016

San Francisco, CA,

Booth: 314