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DMB

Cat. No. 8874 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: GSDMD (Gasdermin D) agonist, activator of pyroptosis, also GLP-1R agonist
Chemical Name: 6,7-Dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-2-quinoxalinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DMB

DMB is a Gasdermin D (GSDMD) agonist (EC50 = 0.7 mM). DMB directly bound to GSDMD (KD = 1.1 mM). DMB activates GSDMD pore formation and pyroptosis without cleaving GSDMD. In vivo, DMB suppresses tumor growth without harming GSDMD-expressing immune cells in mouse tumor models. DMB is also an agonist of glucagon-like peptide 1 receptor. DMB is orally bioavailable.

Technical Data for DMB

M. Wt 348.25
Formula C13H15Cl2N3O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 281209-71-0
PubChem ID 16007289
InChI Key GNZCSGYHILBXLL-UHFFFAOYSA-N
Smiles O=S(=O)(C1=NC=2C=C(Cl)C(Cl)=CC2N=C1NC(C)(C)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DMB

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.41 50

Preparing Stock Solutions for DMB

The following data is based on the product molecular weight 348.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.74 mL 28.72 mL 57.43 mL
2.5 mM 1.15 mL 5.74 mL 11.49 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
25 mM 0.11 mL 0.57 mL 1.15 mL

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References for DMB

References are publications that support the biological activity of the product.

Fontana (2024) Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity. Cell 187 6165 PMID: 39243763

If you know of a relevant reference for DMB, please let us know.

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Keywords: DMB, DMB supplier, GSDMD, Gasdermin, D, agonists, tumor, cancer, in, vivo, orally, bioavailable, pyroptosis, GLP-1R, inflammatory, cell, death, Glucagon-Like, Peptide, 1, Receptors, Inflammasomes, 8874, Tocris Bioscience

Citations for DMB

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