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Description: IMPDH2 (inosine monophosphate dehydrogenase 2) inhibitor, also glioblastoma targeting Nicotinamide mimetic prodrug
Chemical Name: N-3-Pyridinyl-2-thiophenecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for Gliocidin
Gliocidin is an IMPDH2 (inosine monophosphate dehydrogenase 2) inhibitor. Gliocidin is a nicotinamide-mimetic prodrug that is anabolized into its tumoricidal metabolite, gliocidin-adenine dinucleotide (GAD). Gliocidin kills glioblastoma cells while sparing non-tumour replicative cells. In vivo, Gliocidin penetrates the blood-brain barrier and extends the survival of mice with orthotopic glioblastoma.
Technical Data for Gliocidin
| M. Wt | 204.25 |
| Formula | C10H8N2OS |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 62289-81-0 |
| PubChem ID | 790407 |
| InChI Key | UPLHUDRMLWWFRE-UHFFFAOYSA-N |
| Smiles | O=C(NC=1C=NC=CC1)C=2SC=CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Gliocidin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.43 | 100 | |
| ethanol | 20.43 | 100 |
Preparing Stock Solutions for Gliocidin
The following data is based on the product molecular weight 204.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.9 mL | 24.48 mL | 48.96 mL |
| 5 mM | 0.98 mL | 4.9 mL | 9.79 mL |
| 10 mM | 0.49 mL | 2.45 mL | 4.9 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.98 mL |
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Product Datasheets for Gliocidin
References for Gliocidin
References are publications that support the biological activity of the product.
Chen et al (2024) Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma. Nature 636 466 PMID: 39567689
If you know of a relevant reference for Gliocidin, please let us know.
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Keywords: Gliocidin, Gliocidin supplier, IMPDH2, inhibitor, inhibitors, inhibition, inhibits, BBB, blood-brain-barrier, glioblastoma, GAD, cancer, tumor, in, vivo, nicotinamide-mimetic, prodrug, Other, Dehydrogenases, 8893, Tocris Bioscience
Citations for Gliocidin
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