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Submit ReviewDeazaflavin, Alkyne New
Description: Photosensitizer for proximity labeling experiments, Alkyne reactive group
Chemical Name: 3-(Hex-5-yn-1-yl)-10-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione
Purity: ≥95% (HPLC)
Biological Activity for Deazaflavin, Alkyne
Deazaflavin, Alkyne is a deazaflavin-based organic photocatalyst bearing a terminal alkyne functional group for use in bioorthogonal conjugation strategies such as copper-catalyzed azide-alkyne cycloaddition (CuAAC). Upon blue light illumination (~450 nm), the deazaflavin photocatalyst undergoes excitation and enables Dexter-type triplet energy transfer to nearby photoactivatable functional groups such as diazirines or aryl azides, leading to covalent labeling of proximal proteins or biomolecules. When tethered to a targeting ligand, peptide, or macromolecule via the alkyne handle, the reagent allows proximity-dependent photolabeling in live cells or complex biological environments.
Technical Data for Deazaflavin, Alkyne
| M. Wt | 307.35 |
| Formula | C18H17N3O2 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | JEQHRFJFVRKSCU-UHFFFAOYSA-N |
| Smiles | O=C1N(CCCCC#C)C(C2=CC3=CC=CC=C3N(C)C2=N1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Deazaflavin, Alkyne
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.07 | 10 |
Preparing Stock Solutions for Deazaflavin, Alkyne
The following data is based on the product molecular weight 307.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.54 mL | 162.68 mL | 325.36 mL |
| 0.5 mM | 6.51 mL | 32.54 mL | 65.07 mL |
| 1 mM | 3.25 mL | 16.27 mL | 32.54 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
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Product Datasheets for Deazaflavin, Alkyne
References for Deazaflavin, Alkyne
References are publications that support the biological activity of the product.
Crocker et al (2025) Energy-transfer photoproximity labelling in live cells using an organic cofactor. Nat.Chem. doi: 10.1038 PMID: 40962911
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