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Submit ReviewGDC 0941 New
Description: Potent pan-class I PI3 kinase inhibitor
Chemical Name: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
Purity: ≥98% (HPLC)
Biological Activity for GDC 0941
GDC 0941 is a potent pan PI3K inhibitor of class I catalytic subunits p110α, δ, β, and γ (IC50 values are 3, 3, 33 and 75 nM, respectively). GDC 0941 inhibits the PI3K/AKT/mTOR signaling pathways and tumor cell growth in vitro and in vivo. GDC 0941 can be used in stem cell differentiation protocols to generate artery and vein endothelial cells from PSCs. GDC 0941 is orally bioavailable.
Technical Data for GDC 0941
| M. Wt | 513.64 |
| Formula | C23H27N7O3S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 957054-30-7 |
| PubChem ID | 17755052 |
| InChI Key | LHNIIDJUOCFXAP-UHFFFAOYSA-N |
| Smiles | O=S(=O)(N1CCN(CC=2SC3=C(N=C(N=C3N4CCOCC4)C=5C=CC=C6NN=CC65)C2)CC1)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GDC 0941
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.36 | 100 |
Preparing Stock Solutions for GDC 0941
The following data is based on the product molecular weight 513.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.73 mL | 19.47 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.89 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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Product Datasheets for GDC 0941
References for GDC 0941
References are publications that support the biological activity of the product.
Ang et al (2022) Generating human artery and vein cells from pluripotent stem cells highlights the arterial tropism of Nipah and Hendra viruses. Cell 185 2523 PMID: 35738284
Loh et al (2025) Protocol for efficient generation of human artery and vein endothelial cells from pluripotent stem cells. STAR Protoc. 6 103494 PMID: 39705146
Folkes et al (2008) The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J.Med.Chem. 51 5522 PMID: 18754654
If you know of a relevant reference for GDC 0941, please let us know.
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