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Description: Lysine-Specific Demethylase 1 (LSD1) inhibitor
Chemical Name: 4-[[4-[[[(1R,2S)-2-Phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]benzoic acid dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for GSK 2879552
GSK 2879552 is a selective lysine-specific demethylase 1 (LSD1) inhibitor. When combined with other small molecules (EPZ-5676, N-methyl-d-aspartate and Bay K 8644), GSK 2879552 accelerates maturation of human pluripotent stem cell-derived neurons. GSK 2879552 inhibits the growth of small cell lung carcinoma (SCLC) and AML lines. In vivo, GSK 2879552 (1.5 mg/kg, p.o.) demonstrates tumor growth inhibition in SCLC xenograph mouse models.
Technical Data for GSK 2879552
| M. Wt | 437.41 |
| Formula | C23H28N2O2.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1902123-72-1 |
| PubChem ID | 121272425 |
| InChI Key | QEKGSBZKRLHQSZ-VSIGASKDSA-N |
| Smiles | OC(C(C=C1)=CC=C1CN(CC2)CCC2CN[C@H]3[C@H](C4=CC=CC=C4)C3)=O.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GSK 2879552
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.75 | 20 | |
| DMSO | 21.87 | 50 |
Preparing Stock Solutions for GSK 2879552
The following data is based on the product molecular weight 437.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.57 mL | 22.86 mL | 45.72 mL |
| 2.5 mM | 0.91 mL | 4.57 mL | 9.14 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.57 mL |
| 25 mM | 0.09 mL | 0.46 mL | 0.91 mL |
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Product Datasheets for GSK 2879552
References for GSK 2879552
References are publications that support the biological activity of the product.
Hergenreder et al (2024) Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. Nat.Biotechnol. 42 1515 PMID: 38168993
Mohammad et al (2015) A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC. Cancer Cell 28 57 PMID: 26175415
If you know of a relevant reference for GSK 2879552, please let us know.
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Citations for GSK 2879552
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.