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NVP-TNKS656

Cat. No. 8913 Submit a Review Datasheet / COA / SDS
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Description: Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells
Chemical Name: N-(Cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-1-piperidineacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NVP-TNKS656

NVP-TNKS656 is a potent inhibitor of tankyrase enzymes (pIC50 values are 7.8 and 8.2 for TNSK1 and TNKS2 respectively). It displays >5000 selectivity over PARP1 and PARP2. In vivo, it disrupts Wnt pathway activity in the MMTV-Wnt1 mouse xenograft model. NVP-TNKS656 is used to generate neurons from epiblast stem cells. NVP-TNKS656 is orally bioavailable.

Technical Data for NVP-TNKS656

M. Wt 494.58
Formula C27H34N4O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1419949-20-4
PubChem ID 136237316
InChI Key DYGBNAYFDZEYBA-UHFFFAOYSA-N
Smiles O=C1N=C(NC2=C1COCC2)CN(C(=O)CN3CCC(C(=O)C4=CC=C(OC)C=C4)CC3)CC5CC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NVP-TNKS656

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.95 10

Preparing Stock Solutions for NVP-TNKS656

The following data is based on the product molecular weight 494.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.22 mL 101.1 mL 202.19 mL
0.5 mM 4.04 mL 20.22 mL 40.44 mL
1 mM 2.02 mL 10.11 mL 20.22 mL
5 mM 0.4 mL 2.02 mL 4.04 mL

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References for NVP-TNKS656

References are publications that support the biological activity of the product.

Medina-Cano et al (2025) A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro. Dev.Cell doi: 10.1016/j.devce PMID: 40876454

Shultz et al (2013) Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J.Med.Chem. 56 6495 PMID: 23844574

If you know of a relevant reference for NVP-TNKS656, please let us know.

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Keywords: NVP-TNKS656, NVP-TNKS656 supplier, Tankirase, inhibitor, inhibits, TNKS1, TNSK2, PARP1, PARP2, selective, potent, stem, cell, orally, bioavailable, in, vivo, Tankyrase, Neural, Stem, Cells, 8913, Tocris Bioscience

Citations for NVP-TNKS656

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Literature in this Area

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Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products