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IMP 2373

Cat. No. 8171 Submit a Review Datasheet / COA / SDS
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Description: pan-DUB activity-based probe with alkyne click handle
Chemical Name: 4-(1-Cyanopyrrolidine-3-carbonyl)-N-[(4-ethynylphenyl)methyl]-1-methylpyrrole-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for IMP 2373

IMP 2373 is a pan-deubiquitinase (pan-DUB) activity-based probe with alkyne click handle. IMP 2373 interacts with more than 35 DUBs in diverse cell lines and across a range of non-toxic concentrations. IMP 2373 can be used to monitor changes in intracellular DUB activity in live cells during pharmacological inhibition and in vivo during MYC deregulation in a model of B cell lymphoma.

Technical Data for IMP 2373

M. Wt 360.42
Formula C21H20N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 169494136
InChI Key URHCOQKMCOCJCX-UHFFFAOYSA-N
Smiles C#CC1=CC=C(CNC(C2=CC(C(C3CN(C#N)CC3)=O)=CN2C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IMP 2373

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.04 100
ethanol 36.04 100

Preparing Stock Solutions for IMP 2373

The following data is based on the product molecular weight 360.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Molarity Calculator

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Reconstitution Calculator

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References for IMP 2373

References are publications that support the biological activity of the product.

Conole et al (2023) Discovery of a potent Deubiquitinase (DUB) small-molecule activity-based probe enables broad spectrum DUB activity profiling in living cells. Angew Chem.Int.Ed.Engl. 62 e202311190 PMID: 37779326

If you know of a relevant reference for IMP 2373, please let us know.

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Citations for IMP 2373

Citations are publications that use Tocris products.

Currently there are no citations for IMP 2373. Do you know of a great paper that uses IMP 2373 from Tocris? Please let us know.

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