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Deazaflavin, Haloalkane

Cat. No. 8987 Submit a Review Datasheet / COA / SDS
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Description: Photosensitizer for proximity labeling experiments, NHS reactive group
Chemical Name: N-(2-(2-((6-Chlorohexyl)oxy)ethoxy)ethyl)-2-(10-methyl-2,4-dioxo-4,10-dihydropyrimido[4,5-b]quinolin-3(2H)-yl)acetamide
Purity: ≥95% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Deazaflavin, Haloalkane

Deazaflavin, Haloalkane is a deazaflavin-based organic photocatalyst covalently linked to a chloroalkane ligand via a short PEG linker. The conjugate enables site-specific tethering of the photocatalyst to proteins genetically fused to HaloTag® in live-cell systems.

Upon blue light illumination (~450 nm), the deazaflavin moiety transfers energy to nearby photoactivatable probes (e.g., diazirines, aryl azides), initiating localized covalent labeling of biomolecules in the immediate vicinity of the HaloTag® fusion protein. The process is dependent on light exposure, the presence of the reactive probe, and spatial proximity to the tethered photocatalyst.

Deazaflavin, Haloalkane is designed for use in photoproximity labeling experiments that aim to study protein interactions or spatial proteomics in live mammalian cells under mild illumination conditions without the use of metal-based photocatalysts.

HaloTag® is a trademark of Promega Corporation.

Technical Data for Deazaflavin, Haloalkane

M. Wt 490.99
Formula C24H31ClN4O5
Storage Store at -20°C
Purity ≥95% (HPLC)
InChI Key CFRUFYBIYIESMB-UHFFFAOYSA-N
Smiles O=C1N(C(C2=CC3=CC=CC=C3N(C2=N1)C)=O)CC(NCCOCCOCCCCCCCl)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Deazaflavin, Haloalkane

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.91 10

Preparing Stock Solutions for Deazaflavin, Haloalkane

The following data is based on the product molecular weight 490.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.37 mL 101.84 mL 203.67 mL
0.5 mM 4.07 mL 20.37 mL 40.73 mL
1 mM 2.04 mL 10.18 mL 20.37 mL
5 mM 0.41 mL 2.04 mL 4.07 mL

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Product Datasheets for Deazaflavin, Haloalkane

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Deazaflavin, Haloalkane

References are publications that support the biological activity of the product.

Crocker et al (2025) Energy-transfer photoproximity labelling in live cells using an organic cofactor. Nat.Chem. doi: 10.1038 PMID: 40962911

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Citations for Deazaflavin, Haloalkane

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