Home / Pharmacology / Enzymes / Kinases / Other Kinases / Other Kinase Inhibitors / HG-9-91-01

HG-9-91-01

Cat. No. 8985 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent pan-salt inducible kinases (SIK1, SIK2 and SIK3) inhibitor. Also inhibits Lat-B-induced EP differentiation via nuclear YAP1 accumulation.
Chemical Name: 1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for HG-9-91-01

HG-9-91-01 is a potent pan-salt inducible kinases (pan-SIKs) inhibitor (IC50 values are 0.92, 6.6 and 9.6 nM for SIK1, SIK2 and SIK3 respectively). HG-9-91-01 inhibits latrunculin B (Lat-B)-induced endocrine progenitors (EP) differentiation via nuclear YAP1 accumulation in vitro. HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in vitro. HG-9-91-01 increases β-cell proliferation in vitro and in vivo (mouse, zebrafish).

Technical Data for HG-9-91-01

M. Wt 567.68
Formula C32H37N7O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1456858-58-4
PubChem ID 78357808
InChI Key UYUHRKLITDJEHB-UHFFFAOYSA-N
Smiles O=C(N(C1=CC=C(C=C1OC)OC)C2=CC(NC3=CC=C(N4CCN(CC4)C)C=C3)=NC=N2)NC5=C(C)C=CC=C5C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HG-9-91-01

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 5.68 10
DMSO 56.77 100

Preparing Stock Solutions for HG-9-91-01

The following data is based on the product molecular weight 567.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.81 mL 17.62 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for HG-9-91-01

References are publications that support the biological activity of the product.

Clark et al (2012) Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc.Natl.Acad.Sci.U.S.A. 109 16986 PMID: 23033494

Tian et al (2025) Salt-inducible kinases transduce mechanical forces into the specification of the pancreatic endocrine lineage. Stem Cell Rep. 20 102444 PMID: 40054471

Charbord et al (2021) In vivo screen identifies a SIK inhibitor that induces beta cell proliferation through a transient UPR. Nat.Metab. 3 682 PMID: 34031592

If you know of a relevant reference for HG-9-91-01, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Kinase Inhibitors

Keywords: HG-9-91-01, HG-9-91-01 supplier, potent, pan, SIK, inhibitor, SIK1, SIK2, SIK3, salt, inducible, kinase, inhibits, differentiation, endocrine, progenitors, EP, YAP1, stem, cells, b-cells, beta-cells, β-cells, proliferation, in, vivo, HG-9-91-01, Other, Kinases, Differentiation, Products, Stem, Cell, Proliferation, 8985, Tocris Bioscience

Citations for HG-9-91-01

Citations are publications that use Tocris products.

Currently there are no citations for HG-9-91-01. Do you know of a great paper that uses HG-9-91-01 from Tocris? Please let us know.

Reviews for HG-9-91-01

There are currently no reviews for this product. Be the first to review HG-9-91-01 and earn rewards!

Have you used HG-9-91-01?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review