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Submit ReviewBromoCatch™ Ligand, Alkyne New
Description: Clickable alkyne-functionalized covalent probe for BromoCatch-tagged proteins
Chemical Name: (2R)-2-((6S)-4-(4-Acrylamidophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)butanamide
Purity: ≥95% (HPLC)
Biological Activity for BromoCatch™ Ligand, Alkyne
BromoCatch™ Ligand, Alkyne is a covalent ligand engineered to irreversibly bind BromoCatch-tagged proteins via selective reaction with the E438C cysteine mutant of the Brd4-BD2 domain. Featuring a terminal alkyne appended to the BromoCatch Ligand scaffold, this ligand enables downstream modification through copper-catalyzed azide-alkyne cycloaddition (CuAAC). BromoCatch™ Ligand, Alkyne facilitates modular tagging of BromoCatch fusions with fluorophores, biotin, affinity tags, or functional moieties, offering a flexible platform for custom probe development. It enables site-specific protein labeling in vitro and is ideal for applications in chemical biology, proteomics, and multiplexed detection assays.
Please refer to this protocol for further information on how to use this product.
BromoCatch is a trademark of Bio-Techne Corp.
Licensing Information
Sold under exclusive licence from the University of Dundee
Technical Data for BromoCatch™ Ligand, Alkyne
| M. Wt | 632.78 |
| Formula | C33H40N6O5S |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | OFMNYRGCADESPS-VIZCGCQYSA-N |
| Smiles | CC1=C(C)SC2=C1C(C3=CC=C(C=C3)NC(C=C)=O)=N[C@@H]([C@H](C(NCCOCCOCCOCC#C)=O)CC)C4=NN=C(C)N24 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BromoCatch™ Ligand, Alkyne
References for BromoCatch™ Ligand, Alkyne
References are publications that support the biological activity of the product.
Rodriguez-Rios (2025) BromoCatch: a self-labelling tag platform for protein analysis and live cell imaging. biorxiv
If you know of a relevant reference for BromoCatch™ Ligand, Alkyne, please let us know.
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Keywords: BromoCatch™ Ligand, Alkyne, BromoCatch™ Ligand, Alkyne supplier, BromoCatch, Ligand, Alkyne, covalent, ligand, Brd4-BD2, domain, CuAAC, fluorophores, biotin, affinity, tags, protein, labeling, proteomics, multiplexed, detection, assays, Platform, 8940, Tocris Bioscience
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