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Description: Protein phosphatase 1 and 2A inhibitor
Chemical Name: 9,10-Deepithio-9,10-didehydroacanthifolicin ammonium salt
Purity: ≥98% (HPLC)
Biological Activity for Okadaic acid ammonium salt
Okadaic acid ammonium salt is a potent inhibitor of protein phosphatase 1 (IC50 = 3 nM) and protein phosphatase 2A (IC50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.
Technical Data for Okadaic acid ammonium salt
| M. Wt | 822.04 |
| Formula | C44H67O13.NH4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 175522-42-6 |
| PubChem ID | 162640608 |
| InChI Key | ZBOMSHVRJSJGNR-GHIYGBLASA-N |
| Smiles | C[C@H]([C@H]1O[C@]2(OCCCC2)CC[C@H]1C)C[C@H](O)[C@@](C([C@H]3O)=C)([H])O[C@@](CC4)([H])[C@@]3([H])O[C@@]54CC[C@H](/C=C/[C@@H](C)[C@H](CC(C)=C6)O[C@@]76O[C@H](C[C@](O)(C)C([O-])=O)CC[C@H]7O)O5.[NH4+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Okadaic acid ammonium salt
| Solubility | Soluble in DMSO |
Product Datasheets for Okadaic acid ammonium salt
References for Okadaic acid ammonium salt
References are publications that support the biological activity of the product.
Cohen et al (1990) Okadaic acid: a new probe for the study of cellular regulation. TiBS 15 98 PMID: 2158158
Haystead et al (1989) Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337 78 PMID: 2562908
McCluskey et al (2002) Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem 45 1151 PMID: 11881984
Nuydens et al (1998) Okadaic acid-induced apopstosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 70 1124 PMID: 9489733
Deng et al (2023) Molecular dynamic simulation on the synergistic corrosion inhibition effect and mechanism of quinoline quaternary ammonium salt and L-methionine. Chem.Technol.Fuels.Oils 59 858
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Keywords: Okadaic acid ammonium salt, Okadaic acid ammonium salt supplier, [78111-17-8], Protein, phosphatase, 1, 2A, inhibitors, inhibits, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A, Okadaic, Acid, 9012, Tocris Bioscience
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