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AZ'9567

Cat. No. 8897 Submit a Review Datasheet / COA / SDS
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Description: Potent MAT2a (methionine adenosyltransferase 2a) inhibitor
Chemical Name: 3-Cyclopropyl-4-[4-(difluoromethoxy)phenyl]-1,4-dihydro-6-(2-methyl-2H-indazol-5-yl)-5H-pyrazolo[4,3-b]pyridin-5-one
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AZ'9567

AZ'9567 is a potent MAT2a (methionine adenosyltransferase 2a) inhibitor (IC50 = 1.3 nM). AZ'9567 shows strong antiproliferative effect on methylthioadenosine phosphorylase (MTAP) null lymphoma, lung, and pancreatic cancer cell lines and in vivo in MTAP KO HCT116 xenograft mouse model (20 mg/kg twice a day). AZ'9567 is orally bioavailable.

Technical Data for AZ'9567

M. Wt 447.45
Formula C24H19F2N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 3056570-19-2
PubChem ID 170995115
InChI Key QEASMQZYZCGOSA-UHFFFAOYSA-N
Smiles O=C1C(C2=CC3=CN(C)N=C3C=C2)=CC4=C(N1C5=CC=C(C=C5)OC(F)F)C(C6CC6)=NN4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZ'9567

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.74 100
ethanol 4.47 10

Preparing Stock Solutions for AZ'9567

The following data is based on the product molecular weight 447.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.17 mL 22.35 mL
5 mM 0.45 mL 2.23 mL 4.47 mL
10 mM 0.22 mL 1.12 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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References for AZ'9567

References are publications that support the biological activity of the product.

Atkinson et al (2024) Development of a series of pyrrolopyridone MAT2A inhibitors. J.Med.Chem. 67 4541 PMID: 38466661

If you know of a relevant reference for AZ'9567, please let us know.

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Citations for AZ'9567

Citations are publications that use Tocris products.

Currently there are no citations for AZ'9567. Do you know of a great paper that uses AZ'9567 from Tocris? Please let us know.

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