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ZYS 1

Cat. No. 8921 Submit a Review Datasheet / COA / SDS
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Description: ADAR1 (adenosine deaminase acting on RNA 1) deaminase inhibitor
Chemical Name: 5'-Chloro-5'-deoxy-2-fluoroadenosine
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ZYS 1

ZYS 1 is an ADAR1 (adenosine deaminase acting on RNA 1) deaminase inhibitor (IC50 = 946 nM). In vitro, ZYS 1 exhibits antiproliferative activity against multiple prostate cancer cell lines. In vivo, ZYS 1 displays antitumor efficacy in prostate cancer cell-derived xenograft mouse model (20 mg and 40 mg per kg (body weight) intraperitoneally, with tumor growth inhibition rates of 66.68% and 81.83%, respectively).

Technical Data for ZYS 1

M. Wt 303.68
Formula C10H11ClFN5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2734853-80-4
PubChem ID 162354766
InChI Key HSCKXTNMVCTWGY-UUOKFMHZSA-N
Smiles NC1=C2C(N([C@@H]3O[C@@H]([C@H]([C@H]3O)O)CCl)C=N2)=NC(F)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ZYS 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.37 100

Preparing Stock Solutions for ZYS 1

The following data is based on the product molecular weight 303.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.46 mL 32.93 mL
5 mM 0.66 mL 3.29 mL 6.59 mL
10 mM 0.33 mL 1.65 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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References for ZYS 1

References are publications that support the biological activity of the product.

Wang et al (2025) Targeting ADAR1 with a small molecule for the treatment of prostate cancer. Nat.Cancer 6 474 PMID: 39930013

If you know of a relevant reference for ZYS 1, please let us know.

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Keywords: ZYS 1, ZYS 1 supplier, ZYS-1, ZYS1, ADAR1, adenosine, deaminase, acting, on, RNA, 1, deaminases, inhibitors, inhibits, inhibition, in, vivo, anti, proliferative, prostate, cancer, anti-tumor, Deaminases, 8921, Tocris Bioscience

Citations for ZYS 1

Citations are publications that use Tocris products.

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