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Description: Selective GluN2A antagonist, blood-brain barrier penetrant
Chemical Name: 5-(2-(4-Chloropyridin-2-yl)-2,2-difluoroethoxy)-6-methyl-N-(pyridin-3-ylmethyl)pyrazine-2-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for JNJ 78911118
JNJ 78911118 is a potent, GluN2A-selective NMDA antagonist (IC50 = 44 nM). JNJ 78911118 shows >200-fold selectivity against GluN1/2B, 2C and 2D receptors. In vitro, JNJ 78911118 promotes increases in dendritic complexity and synapse number. In vivo, JNJ 78911118 increases mEPSC frequency in rat cortical neurons, and heart rate and blood pressure in rat toxicological studies. JNJ 78911118 is orally bioavailable and blood-brain barrier penetrant.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the JNJ 78911118 probe summary on the SGC website.
Technical Data for JNJ 78911118
| M. Wt | 419.82 |
| Formula | C19H16ClF2N5O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| InChI Key | YPXUKPNZQTWCRR-UHFFFAOYSA-N |
| Smiles | CC1=C(N=CC(C(NCC2=CN=CC=C2)=O)=N1)OCC(F)(C3=NC=CC(Cl)=C3)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JNJ 78911118
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.98 | 100 | |
| ethanol | 41.98 | 100 |
Preparing Stock Solutions for JNJ 78911118
The following data is based on the product molecular weight 419.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.91 mL | 23.82 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for JNJ 78911118
References for JNJ 78911118
References are publications that support the biological activity of the product.
Bischoff et al (2025) Design, synthesis, and characterization of GluN2A negative allosteric modulators suitable for in vivo exploration. J.Med.Chem. 68 4672 PMID: 39960408
Lord et al (2025) Pharmacological characterisation of JNJ-78911118, a novel, centrally-penetrant, selective GluN2A antagonist. Br.J.Pharmacol. 182 4080 PMID: 40361296
If you know of a relevant reference for JNJ 78911118, please let us know.
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Citations for JNJ 78911118
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