EMD 527040 hydrochloride

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Description: ανβ6 integrin inhibitor
Chemical Name: N-[1-Oxo-5-(2-pyridinylamino)pentyl]-O-(phenylmethyl)-L-seryl-3-(3,5-dichlorophenyl)-β-alanine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for EMD 527040 hydrochloride

EMD 527040 hydrochloride is an inhibitor of integrin αVβ6. EMD 527040 inhibits binding of αVβ6 to fibronectin and attachment of cells expressing αVβ6 to fibronectin (IC50 values = 6 nM and 1.6 μM, respectively). EMD 527040 shows antifibrotic effects in an animal model of biliary fibrosis and is active in vivo.

Technical Data for EMD 527040 hydrochloride

M. Wt 623.96
Formula C29H32Cl2N4O5.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key BCWLDUVFBWVDQT-MRUATQDUSA-N
Smiles ClC1=CC(C(CC(O)=O)NC(C(COCC2=CC=CC=C2)NC(CCCCNC3=NC=CC=C3)=O)=O)=CC(Cl)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EMD 527040 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 62.4 100
ethanol 62.4 100

Preparing Stock Solutions for EMD 527040 hydrochloride

The following data is based on the product molecular weight 623.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.6 mL 8.01 mL 16.03 mL
5 mM 0.32 mL 1.6 mL 3.21 mL
10 mM 0.16 mL 0.8 mL 1.6 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets for EMD 527040 hydrochloride

Certificate of Analysis / Product Datasheet
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References for EMD 527040 hydrochloride

References are publications that support the biological activity of the product.

Patsenker et al (2008) Inhibition of integrin αvβ6 on cholangiocytes blocks transforming growth factor-β activation and retards biliary fibrosis progression. Gastroenterology 135 660 PMID: 18538673


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Citations for EMD 527040 hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

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  • Complement System
  • Immune Cell Signaling
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Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.