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EMD 527040 hydrochloride
Biological Activity for EMD 527040 hydrochloride
EMD 527040 hydrochloride is an inhibitor of integrin αVβ6. EMD 527040 inhibits binding of αVβ6 to fibronectin and attachment of cells expressing αVβ6 to fibronectin (IC50 values = 6 nM and 1.6 μM, respectively). EMD 527040 shows antifibrotic effects in an animal model of biliary fibrosis and is active in vivo.
Technical Data for EMD 527040 hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for EMD 527040 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for EMD 527040 hydrochloride
The following data is based on the product molecular weight 623.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.6 mL||8.01 mL||16.03 mL|
|5 mM||0.32 mL||1.6 mL||3.21 mL|
|10 mM||0.16 mL||0.8 mL||1.6 mL|
|50 mM||0.03 mL||0.16 mL||0.32 mL|
Product Datasheets for EMD 527040 hydrochloride
References for EMD 527040 hydrochloride
References are publications that support the biological activity of the product.
Patsenker et al (2008) Inhibition of integrin αvβ6 on cholangiocytes blocks transforming growth factor-β activation and retards biliary fibrosis progression. Gastroenterology 135 660 PMID: 18538673
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Citations for EMD 527040 hydrochloride
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