TR 14035

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Description: Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable
Chemical Name: (αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for TR 14035

TR 14035 is a potent integrin α4β7 and α4β1 antagonist (IC50 values are 7 and 87 nM, respectively). Inhibits binding of HEK 293 cells to osteopontin forms. Orally bioavailable.

Compound Libraries for TR 14035

TR 14035 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TR 14035

M. Wt 474.33
Formula C24H21Cl2NO5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 232271-19-1
PubChem ID 9912743
InChI Key DRSJLVGDSNWQBI-SFHVURJKSA-N
Smiles COC1=CC=CC(OC)=C1C1=CC=C(C[C@H](NC(=O)C2=C(Cl)C=CC=C2Cl)C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TR 14035

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.43 100
ethanol 9.49 20

Preparing Stock Solutions for TR 14035

The following data is based on the product molecular weight 474.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References for TR 14035

References are publications that support the biological activity of the product.

Sircar et al (2002) Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual α4β74β1 integrin antagonist. Bioorg.Med.Chem. 6 20151 PMID: 11937364

Jürets et al (2019) Inhibition of cellular adhesion by immunological targeting of osteopontin neoepitopes generated through matrix metalloproteinase and thrombin cleavage. PLoS One 11 e0148333 PMID: 26840958


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Keywords: TR 14035, TR 14035 supplier, TR14035, potent, integrin, antagonist, alpha4beta1, alpha4beta7, alfa4, a4b1, a4b7, β, α, orally, bioavailable, Integrins, 6908, Tocris Bioscience

Citations for TR 14035

Citations are publications that use Tocris products.

Currently there are no citations for TR 14035. Do you know of a great paper that uses TR 14035 from Tocris? Please let us know.

Reviews for TR 14035

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.