You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent integrin α4β7 and α4β1 antagonist (IC50 values are 7 and 87 nM, respectively). Inhibits binding of HEK 293 cells to osteopontin forms. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 474.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.11 mL||10.54 mL||21.08 mL|
|5 mM||0.42 mL||2.11 mL||4.22 mL|
|10 mM||0.21 mL||1.05 mL||2.11 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
References are publications that support the biological activity of the product.
Sircar et al (2002) Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual α4β7/α4β1 integrin antagonist. Bioorg.Med.Chem. 6 20151 PMID: 11937364
Jürets et al (2019) Inhibition of cellular adhesion by immunological targeting of osteopontin neoepitopes generated through matrix metalloproteinase and thrombin cleavage. PLoS One 11 e0148333 PMID: 26840958
If you know of a relevant reference for TR 14035, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TR 14035, TR 14035 supplier, TR14035, potent, integrin, antagonist, alpha4beta1, alpha4beta7, alfa4, a4b1, a4b7, β, α, orally, bioavailable, Integrins, 6908, Tocris Bioscience
Citations for TR 14035
Citations are publications that use Tocris products.
Currently there are no citations for TR 14035. Do you know of a great paper that uses TR 14035 from Tocris? Please let us know.
Reviews for TR 14035
There are currently no reviews for this product. Be the first to review TR 14035 and earn rewards!
Have you used TR 14035?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.