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Biological Activity for TR 14035
TR 14035 is a potent integrin α4β7 and α4β1 antagonist (IC50 values are 7 and 87 nM, respectively). Inhibits binding of HEK 293 cells to osteopontin forms. Orally bioavailable.
Compound Libraries for TR 14035
Technical Data for TR 14035
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TR 14035
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TR 14035
The following data is based on the product molecular weight 474.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.11 mL||10.54 mL||21.08 mL|
|5 mM||0.42 mL||2.11 mL||4.22 mL|
|10 mM||0.21 mL||1.05 mL||2.11 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
References for TR 14035
References are publications that support the biological activity of the product.
Sircar et al (2002) Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual α4β7/α4β1 integrin antagonist. Bioorg.Med.Chem. 6 20151 PMID: 11937364
Jürets et al (2019) Inhibition of cellular adhesion by immunological targeting of osteopontin neoepitopes generated through matrix metalloproteinase and thrombin cleavage. PLoS One 11 e0148333 PMID: 26840958
If you know of a relevant reference for TR 14035, please let us know.
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Citations for TR 14035
Citations are publications that use Tocris products.
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Literature in this Area
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